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• W2158264375 abstract "// Bo Zhang 1,* , Jing Wang 2,* , Zhen Huang 2 , Peng Wei 1,3 , Ying Liu 4 , Junfeng Hao 1 , Lijing Zhao 1 , Fenglin Zhang 1 , Yaping Tu 5 and Taotao Wei 1 1 National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China 2 Department of Breast Surgical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences, Beijing, China 3 University of Chinese Academy of Sciences, Beijing, China 4 School of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei, China 5 Department of Pharmacology, Creighton University School of Medicine, Omaha, Nebraska, USA * These authors have contributed equally to this work Correspondence to: Taotao Wei, email: // Keywords : TRAP1, mitochondria, tumorigenesis, metastasis, breast cancer Received : February 11, 2015 Accepted : October 21, 2015 Published : October 27, 2015 Abstract Tumor necrosis factor receptor-associated protein 1 (TRAP1) is abnormally expressed in many cancers. In this study, we showed that TRAP1 is aberrantly upregulated in breast tumors compared to control tissues. TRAP1 knockdown downregulates mitochondrial aerobic respiratory, sensitizes cells to lethal stimuli, and inhibited tumor growth in MDA-MB-231 and MCF-7 breast cancer cells in vivo . TRAP1 overexpression, however, enhances the capacity to cope with stress conditions. These evidences suggested that TRAP1 is required for tumorigenesis. We also found that TRAP1 regulates the mitochondrial morphology. Relatively lower TRAP1 levels are associated with the rod-shaped mitochondrial phenotype in invasive and metastatic MDA-MB-231 breast cancer cells; on the contrary, higher TRAP1 levels are associated with the tubular network-shaped mitochondrial phenotype in non-invasive MCF-7 cells. Interestingly, the expression of TRAP1 in human breast cancer specimens inversely correlates with tumor grade. Overexpression of TRAP1 in MDA-MB-231 cells causes mitochondrial fusion, triggers mitochondria to form tubular networks, and suppresses cell migration and invasion in vitro and in vivo . These data link TRAP1-regulated mitochondrial dynamics and function with tumorigenesis of breast cancer and suggested that TRAP1 may therefore be a potential target for breast cancer drug development." @default.
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• W2158264375 date "2015-10-27" @default.
• W2158264375 modified "2023-09-25" @default.
• W2158264375 title "Aberrantly upregulated TRAP1 is required for tumorigenesis of breast cancer" @default.
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• W2158264375 doi "https://doi.org/10.18632/oncotarget.6252" @default.
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