Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158316748> ?p ?o ?g. }
- W2158316748 endingPage "374" @default.
- W2158316748 startingPage "363" @default.
- W2158316748 abstract "The different members of the vascular endothelial growth factor (VEGF) family act as key regulators of endothelial cell function controlling vasculogenesis, angiogenesis, vascular permeability and endothelial cell survival. In this study, we have functionally characterized a novel member of the VEGF family, designated VEGF-E. VEGF-E sequences are encoded by the parapoxvirus Orf virus (OV). They carry the characteristic cysteine knot motif present in all mammalian VEGFs, while forming a microheterogenic group distinct from previously described members of this family. VEGF-E was expressed as the native protein in mammalian cells or as a recombinant protein in Escherichia coli and was shown to act as a heat-stable, secreted dimer. VEGF-E and VEGF-A were found to possess similar bioactivities, i.e. both factors stimulate the release of tissue factor (TF), the proliferation, chemotaxis and sprouting of cultured vascular endothelial cells in vitro and angiogenesis in vivo. Like VEGF-A, VEGF-E was found to bind with high affinity to VEGF receptor-2 (KDR) resulting in receptor autophosphorylation and a biphasic rise in free intracellular Ca2+ concentration, whilst in contrast to VEGF-A, VEGF-E did not bind to VEGF receptor-1 (Flt-1). VEGF-E is thus a potent angiogenic factor selectively binding to VEGF receptor-2. These data strongly indicate that activation of VEGF receptor-2 alone can efficiently stimulate angiogenesis." @default.
- W2158316748 created "2016-06-24" @default.
- W2158316748 creator A5007083753 @default.
- W2158316748 creator A5018962844 @default.
- W2158316748 creator A5023859224 @default.
- W2158316748 creator A5033335642 @default.
- W2158316748 creator A5044455209 @default.
- W2158316748 creator A5046753253 @default.
- W2158316748 creator A5059071205 @default.
- W2158316748 creator A5064671722 @default.
- W2158316748 creator A5076622030 @default.
- W2158316748 creator A5088506636 @default.
- W2158316748 date "1999-01-15" @default.
- W2158316748 modified "2023-10-14" @default.
- W2158316748 title "A novel vascular endothelial growth factor encoded by Orf virus, VEGF-E, mediates angiogenesis via signalling through VEGFR-2 (KDR) but not VEGFR-1 (Flt-1) receptor tyrosine kinases" @default.
- W2158316748 cites W128176000 @default.
- W2158316748 cites W1489873347 @default.
- W2158316748 cites W1499692647 @default.
- W2158316748 cites W1560943379 @default.
- W2158316748 cites W1582316077 @default.
- W2158316748 cites W1587020653 @default.
- W2158316748 cites W1679229092 @default.
- W2158316748 cites W1965380392 @default.
- W2158316748 cites W1980573811 @default.
- W2158316748 cites W1981612052 @default.
- W2158316748 cites W1985712533 @default.
- W2158316748 cites W1986023276 @default.
- W2158316748 cites W1986559037 @default.
- W2158316748 cites W1987644022 @default.
- W2158316748 cites W1988655450 @default.
- W2158316748 cites W1991958278 @default.
- W2158316748 cites W1996024251 @default.
- W2158316748 cites W1996781360 @default.
- W2158316748 cites W2000000541 @default.
- W2158316748 cites W2008940139 @default.
- W2158316748 cites W2013561902 @default.
- W2158316748 cites W2015789556 @default.
- W2158316748 cites W2017205210 @default.
- W2158316748 cites W2023276162 @default.
- W2158316748 cites W2023453327 @default.
- W2158316748 cites W2025933554 @default.
- W2158316748 cites W2029763523 @default.
- W2158316748 cites W2034767282 @default.
- W2158316748 cites W2044368032 @default.
- W2158316748 cites W2045247659 @default.
- W2158316748 cites W2046044320 @default.
- W2158316748 cites W2049569341 @default.
- W2158316748 cites W2050252862 @default.
- W2158316748 cites W2050358495 @default.
- W2158316748 cites W2057973294 @default.
- W2158316748 cites W2062594120 @default.
- W2158316748 cites W2063782675 @default.
- W2158316748 cites W2067817921 @default.
- W2158316748 cites W2076374640 @default.
- W2158316748 cites W2077861409 @default.
- W2158316748 cites W2078083828 @default.
- W2158316748 cites W2082201610 @default.
- W2158316748 cites W2084506573 @default.
- W2158316748 cites W2084947524 @default.
- W2158316748 cites W2093457985 @default.
- W2158316748 cites W2093498435 @default.
- W2158316748 cites W2094633119 @default.
- W2158316748 cites W2106882534 @default.
- W2158316748 cites W2117262917 @default.
- W2158316748 cites W2121594719 @default.
- W2158316748 cites W2141260882 @default.
- W2158316748 cites W2143260418 @default.
- W2158316748 cites W2146021659 @default.
- W2158316748 cites W2166156136 @default.
- W2158316748 cites W2171543828 @default.
- W2158316748 cites W2171864934 @default.
- W2158316748 cites W2294836073 @default.
- W2158316748 cites W2341983048 @default.
- W2158316748 cites W2395742536 @default.
- W2158316748 cites W2410916497 @default.
- W2158316748 cites W2418610767 @default.
- W2158316748 cites W4249388929 @default.
- W2158316748 doi "https://doi.org/10.1093/emboj/18.2.363" @default.
- W2158316748 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1171131" @default.
- W2158316748 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9889193" @default.
- W2158316748 hasPublicationYear "1999" @default.
- W2158316748 type Work @default.
- W2158316748 sameAs 2158316748 @default.
- W2158316748 citedByCount "466" @default.
- W2158316748 countsByYear W21583167482012 @default.
- W2158316748 countsByYear W21583167482013 @default.
- W2158316748 countsByYear W21583167482014 @default.
- W2158316748 countsByYear W21583167482015 @default.
- W2158316748 countsByYear W21583167482016 @default.
- W2158316748 countsByYear W21583167482017 @default.
- W2158316748 countsByYear W21583167482018 @default.
- W2158316748 countsByYear W21583167482019 @default.
- W2158316748 countsByYear W21583167482020 @default.
- W2158316748 countsByYear W21583167482021 @default.
- W2158316748 countsByYear W21583167482022 @default.
- W2158316748 countsByYear W21583167482023 @default.
- W2158316748 crossrefType "journal-article" @default.
- W2158316748 hasAuthorship W2158316748A5007083753 @default.