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• W2158317960 abstract "Soluble epoxide hydrolase (EH) from the potato Solanum tuberosum and an evolved EH of the bacterium Agrobacterium radiobacter AD1, EchA-I219F, were purified for the enantioconvergent hydrolysis of racemic styrene oxide into the single product (R)-1-phenyl-1,2-ethanediol, which is an important intermediate for pharmaceuticals. EchA-I219F has enhanced enantioselectivity (enantiomeric ratio of 91 based on products) for converting (R)-styrene oxide to (R)-1-phenyl-1,2-ethanediol (2.0 ± 0.2 µmol/min/mg), and the potato EH converts (S)-styrene oxide primarily to the same enantiomer, (R)-1-phenyl-1,2-ethanediol (22 ± 1 µmol/min/mg), with an enantiomeric ratio of 40 ± 17 (based on substrates). By mixing these two purified enzymes, inexpensive racemic styrene oxide (5 mM) was converted at 100% yield to 98% enantiomeric excess (R)-1-phenyl-1,2-ethanediol at 4.7 ± 0.7 µmol/min/mg. Hence, at least 99% of substrate is converted into a single stereospecific product at a rapid rate. © 2006 Wiley Periodicals, Inc." @default.
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• W2158317960 date "2006-06-20" @default.
• W2158317960 modified "2023-09-27" @default.
• W2158317960 title "Enantioconvergent production of (R)-1-phenyl-1,2-ethanediol from styrene oxide by combining theSolanum tuberosum and an evolvedAgrobacterium radiobacter AD1 epoxide hydrolases" @default.
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• W2158317960 doi "https://doi.org/10.1002/bit.20860" @default.
• W2158317960 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16498626" @default.
• W2158317960 hasPublicationYear "2006" @default.
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