FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158329042> ?p ?o ?g. }

• W2158329042 endingPage "1697" @default.
• W2158329042 startingPage "1683" @default.
• W2158329042 abstract "To clarify the role of mitochondrial Na(+)-Ca(2+) exchange (NCX(mito)) in regulating mitochondrial Ca(2+) (Ca(2+)(mito)) concentration at intact and depolarized mitochondrial membrane potential (DeltaPsi(mito)), we measured Ca(2+)(mito) and DeltaPsi(mito) using fluorescence probes Rhod-2 and TMRE, respectively, in the permeabilized rat ventricular cells. Applying 300 nm cytoplasmic Ca(2+) (Ca(2+)(c)) increased Ca(2+)(mito) and this increase was attenuated by cytoplasmic Na(+) (Na(+)(c)) with an IC(50) of 2.4 mm. To the contrary, when DeltaPsi(mito) was depolarized by FCCP, a mitochondrial uncoupler, Na(+)(c) enhanced the Ca(2+)(c)-induced increase in Ca(2+)(mito) with an EC(50) of about 4 mm. This increase was not significantly affected by ruthenium red or cyclosporin A. The inhibition of NCX(mito) by CGP-37157 further increased Ca(2+)(mito) when DeltaPsi(mito) was intact, while it suppressed the Ca(2+)(mito) increase when DeltaPsi(mito) was depolarized, suggesting that DeltaPsi(mito) depolarization changed the exchange mode from forward to reverse. Furthermore, DeltaPsi(mito) depolarization significantly reduced the Ca(2+)(mito) decrease via forward mode, and augmented the Ca(2+)(mito) increase via reverse mode. When the respiratory chain was attenuated, the induction of the reverse mode of NCX(mito) hyperpolarized DeltaPsi(mito), while DeltaPsi(mito) depolarized upon inducing the forward mode of NCX(mito). Both changes in DeltaPsi(mito) were remarkably inhibited by CGP-37157. The above experimental data indicated that NCX(mito) is voltage dependent and electrogenic. This notion was supported theoretically by computer simulation studies with an NCX(mito) model constructed based on present and previous studies, presuming a consecutive and electrogenic Na(+)-Ca(2+) exchange and a depolarization-induced increase in Na(+) flux. It is concluded that Ca(2+)(mito) concentration is dynamically modulated by Na(+)(c) and DeltaPsi(mito) via electrogenic NCX(mito)." @default.
• W2158329042 created "2016-06-24" @default.
• W2158329042 creator A5011910796 @default.
• W2158329042 creator A5017240065 @default.
• W2158329042 date "2008-03-15" @default.
• W2158329042 modified "2023-09-27" @default.
• W2158329042 title "Cytoplasmic Na⁺-dependent modulation of mitochondrial Ca²⁺via electrogenic mitochondrial Na⁺-Ca²⁺exchange" @default.
• W2158329042 cites W150246076 @default.
• W2158329042 cites W1564917523 @default.
• W2158329042 cites W1569293583 @default.
• W2158329042 cites W1874250570 @default.
• W2158329042 cites W1920479129 @default.
• W2158329042 cites W193006127 @default.
• W2158329042 cites W1935060748 @default.
• W2158329042 cites W1965116904 @default.
• W2158329042 cites W1967575622 @default.
• W2158329042 cites W1967908311 @default.
• W2158329042 cites W1968011444 @default.
• W2158329042 cites W1969195108 @default.
• W2158329042 cites W1972319192 @default.
• W2158329042 cites W1979001792 @default.
• W2158329042 cites W1983820893 @default.
• W2158329042 cites W1986560775 @default.
• W2158329042 cites W1991220984 @default.
• W2158329042 cites W1994377924 @default.
• W2158329042 cites W1994711246 @default.
• W2158329042 cites W2005945017 @default.
• W2158329042 cites W2010422175 @default.
• W2158329042 cites W2010572143 @default.
• W2158329042 cites W2010679092 @default.
• W2158329042 cites W2014100516 @default.
• W2158329042 cites W2015897555 @default.
• W2158329042 cites W2020922831 @default.
• W2158329042 cites W2022250720 @default.
• W2158329042 cites W2023707009 @default.
• W2158329042 cites W2026644067 @default.
• W2158329042 cites W2030966306 @default.
• W2158329042 cites W2031583642 @default.
• W2158329042 cites W2042391144 @default.
• W2158329042 cites W2052425217 @default.
• W2158329042 cites W2055850256 @default.
• W2158329042 cites W2059483340 @default.
• W2158329042 cites W2068048197 @default.
• W2158329042 cites W2069885795 @default.
• W2158329042 cites W2078132151 @default.
• W2158329042 cites W2092910438 @default.
• W2158329042 cites W2097812077 @default.
• W2158329042 cites W2106025757 @default.
• W2158329042 cites W2112696881 @default.
• W2158329042 cites W2118586239 @default.
• W2158329042 cites W2123833817 @default.
• W2158329042 cites W2147607863 @default.
• W2158329042 cites W2148230219 @default.
• W2158329042 cites W2156826654 @default.
• W2158329042 cites W2158712715 @default.
• W2158329042 cites W2166072538 @default.
• W2158329042 cites W2206671577 @default.
• W2158329042 cites W2331292524 @default.
• W2158329042 cites W2430065665 @default.
• W2158329042 cites W4243727692 @default.
• W2158329042 doi "https://doi.org/10.1113/jphysiol.2007.148726" @default.
• W2158329042 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2375703" @default.
• W2158329042 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18218682" @default.
• W2158329042 hasPublicationYear "2008" @default.
• W2158329042 type Work @default.
• W2158329042 sameAs 2158329042 @default.
• W2158329042 citedByCount "80" @default.
• W2158329042 countsByYear W21583290422012 @default.
• W2158329042 countsByYear W21583290422013 @default.
• W2158329042 countsByYear W21583290422014 @default.
• W2158329042 countsByYear W21583290422015 @default.
• W2158329042 countsByYear W21583290422016 @default.
• W2158329042 countsByYear W21583290422018 @default.
• W2158329042 countsByYear W21583290422019 @default.
• W2158329042 countsByYear W21583290422020 @default.
• W2158329042 countsByYear W21583290422021 @default.
• W2158329042 countsByYear W21583290422022 @default.
• W2158329042 countsByYear W21583290422023 @default.
• W2158329042 crossrefType "journal-article" @default.
• W2158329042 hasAuthorship W2158329042A5011910796 @default.
• W2158329042 hasAuthorship W2158329042A5017240065 @default.
• W2158329042 hasBestOaLocation W21583290422 @default.
• W2158329042 hasConcept C12554922 @default.
• W2158329042 hasConcept C153911025 @default.
• W2158329042 hasConcept C178790620 @default.
• W2158329042 hasConcept C181911157 @default.
• W2158329042 hasConcept C185592680 @default.
• W2158329042 hasConcept C190062978 @default.
• W2158329042 hasConcept C2779657890 @default.
• W2158329042 hasConcept C28859421 @default.
• W2158329042 hasConcept C4141045 @default.
• W2158329042 hasConcept C519063684 @default.
• W2158329042 hasConcept C55493867 @default.
• W2158329042 hasConcept C75385678 @default.
• W2158329042 hasConcept C86803240 @default.
• W2158329042 hasConceptScore W2158329042C12554922 @default.
• W2158329042 hasConceptScore W2158329042C153911025 @default.
• W2158329042 hasConceptScore W2158329042C178790620 @default.

• next