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- W2158331815 abstract "Besides industrially produced gibberellins (GAs), Fusarium fujikuroi is able to produce additional secondary metabolites such as the pigments bikaverin and neurosporaxanthin and the mycotoxins fumonisins and fusarin C. The global regulation of these biosynthetic pathways is only poorly understood. Recently, the velvet complex containing VeA and several other regulatory proteins was shown to be involved in global regulation of secondary metabolism and differentiation in Aspergillus nidulans. Here, we report on the characterization of two components of the F. fujikuroi velvet-like complex, FfVel1 and FfLae1. The gene encoding this first reported LaeA orthologue outside the class of Eurotiomycetidae is upregulated in ΔFfvel1 microarray-studies and FfLae1 interacts with FfVel1 in the nucleus. Deletion of Ffvel1 and Fflae1 revealed for the first time that velvet can simultaneously act as positive (GAs, fumonisins and fusarin C) and negative (bikaverin) regulator of secondary metabolism, and that both components affect conidiation and virulence of F. fujikuroi. Furthermore, the velvet-like protein FfVel2 revealed similar functions regarding conidiation, secondary metabolism and virulence as FfVel1. Cross-genus complementation studies of velvet complex component mutants between Fusarium, Aspergillus and Penicillium support an ancient origin for this complex, which has undergone a divergence in specific functions mediating development and secondary metabolism." @default.
- W2158331815 created "2016-06-24" @default.
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- W2158331815 date "2010-07-12" @default.
- W2158331815 modified "2023-10-17" @default.
- W2158331815 title "FfVel1 and FfLae1, components of a velvet-like complex in Fusarium fujikuroi, affect differentiation, secondary metabolism and virulence" @default.
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- W2158331815 doi "https://doi.org/10.1111/j.1365-2958.2010.07263.x" @default.
- W2158331815 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2989987" @default.
- W2158331815 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20572938" @default.
- W2158331815 hasPublicationYear "2010" @default.
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