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- W2158346543 endingPage "1183" @default.
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- W2158346543 abstract "We describe a simple and robust method to construct complex three-dimensional (3D) structures by using short synthetic DNA strands that we call DNA bricks. In one-step annealing reactions, bricks with hundreds of distinct sequences self-assemble into prescribed 3D shapes. Each 32-nucleotide brick is a modular component; it binds to four local neighbors and can be removed or added independently. Each 8-base pair interaction between bricks defines a voxel with dimensions of 2.5 by 2.5 by 2.7 nanometers, and a master brick collection defines a molecular canvas with dimensions of 10 by 10 by 10 voxels. By selecting subsets of bricks from this canvas, we constructed a panel of 102 distinct shapes exhibiting sophisticated surface features, as well as intricate interior cavities and tunnels." @default.
- W2158346543 created "2016-06-24" @default.
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- W2158346543 creator A5040711703 @default.
- W2158346543 creator A5061178695 @default.
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- W2158346543 date "2012-11-30" @default.
- W2158346543 modified "2023-10-09" @default.
- W2158346543 title "Three-Dimensional Structures Self-Assembled from DNA Bricks" @default.
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- W2158346543 doi "https://doi.org/10.1126/science.1227268" @default.
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