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- W2158349112 startingPage "287" @default.
- W2158349112 abstract "Corneal transplantation is the most commonly performed organ transplantation. Immune privilege of the cornea is widely recognized, partly because of the relatively favorable outcome of corneal grafts. The first-time recipient of corneal allografts in an avascular, low-risk setting can expect a 90% success rate without systemic immunosuppressive agents and histocompatibility matching. However, immunologic rejection remains the major cause of graft failure, particularly in patients with a high risk for rejection. Corticosteroids remain the first-line therapy for the prevention and treatment of immune rejection. However, current pharmacological measures are limited in their side-effect profiles, repeated application, lack of targeted response, and short duration of action. Experimental ocular gene therapy may thus present new horizons in immunomodulation. From efficient viral vectors to sustainable alternative splicing, we discuss the progress of gene therapy in promoting graft survival and postulate further avenues for gene-mediated prevention of allogeneic graft rejection." @default.
- W2158349112 created "2016-06-24" @default.
- W2158349112 creator A5056876383 @default.
- W2158349112 creator A5060347940 @default.
- W2158349112 date "2013-09-01" @default.
- W2158349112 modified "2023-10-18" @default.
- W2158349112 title "Gene Therapy in Corneal Transplantation" @default.
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