Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158361034> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2158361034 endingPage "1560" @default.
- W2158361034 startingPage "1555" @default.
- W2158361034 abstract "Fertility of Drosophila melanogaster males is impaired due to the disruption of the silencing of the X-linked, testis-expressed, repeated Stellate (Ste) genes. Ste silencing is mediated by symmetric transcription of the paralogous Y-linked repeats and exerted by an RNA interference (RNAi) mechanism. Here we present a scenario for the origin of the Ste genes and their suppressors. The primary intermediate of their evolution emerged as a result of the acquisition of a preformed alien, testis-specific promoter. This intermediate is identified as a chimeric gene containing coding region of an autosomal gene for testis-specific protein kinase CK2. The 5' region of the chimera has been acquired from a member of a family of testis-expressed X-linked genes of unknown function. We propose that the evolution and amplification of the novel chimeric gene have led to the overproduction of the regulatory CK2 subunit in testes. The evolution of the Y-linked descendants of the primary intermediate resulted in the RNAi-mediated suppression of excessive expression of the X-linked paralogs. The newly detected dead family of cognate repeats on the Y chromosome has contributed to the evolution of Ste and its suppressors via gene conversion. Our results show that RNAi silencing, considered as a defense against viruses and transposable elements, may be involved in the evolution of eukaryotic genomes." @default.
- W2158361034 created "2016-06-24" @default.
- W2158361034 creator A5004505475 @default.
- W2158361034 creator A5078882430 @default.
- W2158361034 creator A5080571120 @default.
- W2158361034 creator A5089935846 @default.
- W2158361034 date "2005-04-13" @default.
- W2158361034 modified "2023-09-25" @default.
- W2158361034 title "An Alien Promoter Capture as a Primary Step of the Evolution of Testes-Expressed Repeats in the Drosophila melanogaster Genome" @default.
- W2158361034 cites W1511673362 @default.
- W2158361034 cites W1590434348 @default.
- W2158361034 cites W1834361763 @default.
- W2158361034 cites W1909683533 @default.
- W2158361034 cites W1934268468 @default.
- W2158361034 cites W1980394440 @default.
- W2158361034 cites W2006729480 @default.
- W2158361034 cites W2022918256 @default.
- W2158361034 cites W2023911222 @default.
- W2158361034 cites W2037541952 @default.
- W2158361034 cites W2051293392 @default.
- W2158361034 cites W2059805279 @default.
- W2158361034 cites W2069393167 @default.
- W2158361034 cites W2077879161 @default.
- W2158361034 cites W2102545675 @default.
- W2158361034 cites W2114043627 @default.
- W2158361034 cites W2129881449 @default.
- W2158361034 cites W2134663818 @default.
- W2158361034 cites W2160169707 @default.
- W2158361034 cites W2161476350 @default.
- W2158361034 cites W2162673429 @default.
- W2158361034 cites W2229304181 @default.
- W2158361034 doi "https://doi.org/10.1093/molbev/msi147" @default.
- W2158361034 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15829619" @default.
- W2158361034 hasPublicationYear "2005" @default.
- W2158361034 type Work @default.
- W2158361034 sameAs 2158361034 @default.
- W2158361034 citedByCount "20" @default.
- W2158361034 countsByYear W21583610342012 @default.
- W2158361034 countsByYear W21583610342014 @default.
- W2158361034 countsByYear W21583610342016 @default.
- W2158361034 countsByYear W21583610342017 @default.
- W2158361034 countsByYear W21583610342018 @default.
- W2158361034 countsByYear W21583610342021 @default.
- W2158361034 countsByYear W21583610342022 @default.
- W2158361034 crossrefType "journal-article" @default.
- W2158361034 hasAuthorship W2158361034A5004505475 @default.
- W2158361034 hasAuthorship W2158361034A5078882430 @default.
- W2158361034 hasAuthorship W2158361034A5080571120 @default.
- W2158361034 hasAuthorship W2158361034A5089935846 @default.
- W2158361034 hasConcept C104317684 @default.
- W2158361034 hasConcept C119056186 @default.
- W2158361034 hasConcept C141231307 @default.
- W2158361034 hasConcept C150194340 @default.
- W2158361034 hasConcept C166703698 @default.
- W2158361034 hasConcept C26260077 @default.
- W2158361034 hasConcept C2776998849 @default.
- W2158361034 hasConcept C2780104201 @default.
- W2158361034 hasConcept C4918238 @default.
- W2158361034 hasConcept C54355233 @default.
- W2158361034 hasConcept C67705224 @default.
- W2158361034 hasConcept C7602840 @default.
- W2158361034 hasConcept C86803240 @default.
- W2158361034 hasConceptScore W2158361034C104317684 @default.
- W2158361034 hasConceptScore W2158361034C119056186 @default.
- W2158361034 hasConceptScore W2158361034C141231307 @default.
- W2158361034 hasConceptScore W2158361034C150194340 @default.
- W2158361034 hasConceptScore W2158361034C166703698 @default.
- W2158361034 hasConceptScore W2158361034C26260077 @default.
- W2158361034 hasConceptScore W2158361034C2776998849 @default.
- W2158361034 hasConceptScore W2158361034C2780104201 @default.
- W2158361034 hasConceptScore W2158361034C4918238 @default.
- W2158361034 hasConceptScore W2158361034C54355233 @default.
- W2158361034 hasConceptScore W2158361034C67705224 @default.
- W2158361034 hasConceptScore W2158361034C7602840 @default.
- W2158361034 hasConceptScore W2158361034C86803240 @default.
- W2158361034 hasIssue "7" @default.
- W2158361034 hasLocation W21583610341 @default.
- W2158361034 hasLocation W21583610342 @default.
- W2158361034 hasOpenAccess W2158361034 @default.
- W2158361034 hasPrimaryLocation W21583610341 @default.
- W2158361034 hasRelatedWork W1573987240 @default.
- W2158361034 hasRelatedWork W2030822261 @default.
- W2158361034 hasRelatedWork W2037025856 @default.
- W2158361034 hasRelatedWork W2076402576 @default.
- W2158361034 hasRelatedWork W2082034785 @default.
- W2158361034 hasRelatedWork W2093113214 @default.
- W2158361034 hasRelatedWork W2095829109 @default.
- W2158361034 hasRelatedWork W2129755904 @default.
- W2158361034 hasRelatedWork W2172076792 @default.
- W2158361034 hasRelatedWork W4315640719 @default.
- W2158361034 hasVolume "22" @default.
- W2158361034 isParatext "false" @default.
- W2158361034 isRetracted "false" @default.
- W2158361034 magId "2158361034" @default.
- W2158361034 workType "article" @default.