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- W2158361979 abstract "Objective To determine the factor-X activating procoagulant activity (FXAA) of prostatic tissue removed at transurethral resection in a specific chromogenic assay. Patients and methods FXAA was extracted from transurethrally resected prostatic tissue using a cryofragmentation technique. Tissue from 50 patients with prostate cancer was analysed and compared with that from 36 control patients with benign prostatic-hypertrophy. Enzyme activities were assayed in a two stage chromogenic assay and correlated with conventional markers of tumour aggressiveness. Results FXAA was found to be significantly lower (P <0.001) in tissue from malignant prostates compared with benign prostatic hypertrophy tissue. Loss Of FXAA was also related to Gleason grade (P <0.03), percentage of chips involved by tumour (P <0.04) and bone scan status (P <0.02). Using antibody inhibition tests this procoagulant was characterized as being a factor VII/tissue factor complex. Conclusions Malignant change in the prostate is associated with a reduction in FXAA and this may be an important factor in prostatic tumour growth anddissemination." @default.
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- W2158361979 date "1994-08-01" @default.
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- W2158361979 title "Procoagulant properties of benign and malignant prostatic tissue" @default.
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- W2158361979 doi "https://doi.org/10.1111/j.1464-410x.1994.tb16587.x" @default.
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