FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158366771> ?p ?o ?g. }

• W2158366771 endingPage "753" @default.
• W2158366771 startingPage "747" @default.
• W2158366771 abstract "Abstract Background Microcomedones representing the clinically non‐visible central precursor lesions of acne are induced by sebaceous hyperplasia as well as altered follicular growth and differentiation, and evolve into both comedones and inflammatory lesions. Thus, targeting microcomedone formation is essential in the prevention and therapeutic control of acne. Objective The aim of this study was to assess the capacity of adapalene gel, 0.1%, to control the number of microcomedones after a combination treatment followed by a maintenance treatment. Methods This was a single‐site exploratory study in subjects with a diagnosis of mild to moderate acne vulgaris and the presence of at least 250 microcomedones per cm 2 at screening visit, counted via cyanoacrylate strips (CyASt). During the first 8 weeks, a combination of adapalene gel (0.1%) and benzoyl peroxide gel (2.5%) was applied. During the randomized, investigator‐blinded, and vehicle‐controlled 12‐week maintenance phase, adapalene once daily (QD), or adapalene alternately with its vehicle once daily every other day (QoD), or vehicle QD were applied to the face. CyASt sampling on the forehead was done at baseline, week 8, and week 20. Lesion counting allowing calculating a defined success rate was done at all visits. Results A total of 54 subjects entered the combination phase, and 49 subjects were randomized into the maintenance phase: 16 in both the adapalene QD and the QoD group and 17 subjects receiving the vehicle. The microcomedone median count decreased for all groups until week 8 (end of combination phase) from 319 to 157. Microcomedone counts at the end of the maintenance phase (week 20) showed a significant percent difference ( P = 0.04) between adapalene QoD (–53.5) and the vehicle (–42.1) and between adapalene QD (–50.6) and the vehicle ( P = 0.037) compared with baseline. Conclusion The application of adapalene gel, 0.1% monotherapy daily, or alternately every other day, significantly helps to control the microcomedone count during a 12‐week maintenance treatment after a previous combination therapy with benzoyl peroxide in patients with mild to moderate acne." @default.
• W2158366771 created "2016-06-24" @default.
• W2158366771 creator A5030916390 @default.
• W2158366771 creator A5042832623 @default.
• W2158366771 creator A5045634965 @default.
• W2158366771 date "2007-06-12" @default.
• W2158366771 modified "2023-10-12" @default.
• W2158366771 title "Control of microcomedone formation throughout a maintenance treatment with adapalene gel, 0.1%" @default.
• W2158366771 cites W1965659086 @default.
• W2158366771 cites W1966709570 @default.
• W2158366771 cites W1986422601 @default.
• W2158366771 cites W1997818637 @default.
• W2158366771 cites W2015924625 @default.
• W2158366771 cites W2017833528 @default.
• W2158366771 cites W2021619085 @default.
• W2158366771 cites W2063696227 @default.
• W2158366771 cites W2070512447 @default.
• W2158366771 cites W2070625128 @default.
• W2158366771 cites W2074713938 @default.
• W2158366771 cites W2084820292 @default.
• W2158366771 cites W2092737273 @default.
• W2158366771 cites W2111319723 @default.
• W2158366771 cites W2122578820 @default.
• W2158366771 cites W2134002686 @default.
• W2158366771 cites W2134540968 @default.
• W2158366771 cites W2139827667 @default.
• W2158366771 cites W2144083903 @default.
• W2158366771 cites W2167817109 @default.
• W2158366771 cites W4233609299 @default.
• W2158366771 cites W4238366209 @default.
• W2158366771 cites W4256214116 @default.
• W2158366771 cites W4383740241 @default.
• W2158366771 cites W47914667 @default.
• W2158366771 doi "https://doi.org/10.1111/j.1468-3083.2007.02190.x" @default.
• W2158366771 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17567301" @default.
• W2158366771 hasPublicationYear "2007" @default.
• W2158366771 type Work @default.
• W2158366771 sameAs 2158366771 @default.
• W2158366771 citedByCount "64" @default.
• W2158366771 countsByYear W21583667712012 @default.
• W2158366771 countsByYear W21583667712013 @default.
• W2158366771 countsByYear W21583667712014 @default.
• W2158366771 countsByYear W21583667712015 @default.
• W2158366771 countsByYear W21583667712016 @default.
• W2158366771 countsByYear W21583667712017 @default.
• W2158366771 countsByYear W21583667712018 @default.
• W2158366771 countsByYear W21583667712019 @default.
• W2158366771 countsByYear W21583667712020 @default.
• W2158366771 countsByYear W21583667712021 @default.
• W2158366771 countsByYear W21583667712022 @default.
• W2158366771 countsByYear W21583667712023 @default.
• W2158366771 crossrefType "journal-article" @default.
• W2158366771 hasAuthorship W2158366771A5030916390 @default.
• W2158366771 hasAuthorship W2158366771A5042832623 @default.
• W2158366771 hasAuthorship W2158366771A5045634965 @default.
• W2158366771 hasConcept C141071460 @default.
• W2158366771 hasConcept C16005928 @default.
• W2158366771 hasConcept C178790620 @default.
• W2158366771 hasConcept C185592680 @default.
• W2158366771 hasConcept C2777140388 @default.
• W2158366771 hasConcept C2777673923 @default.
• W2158366771 hasConcept C2778885487 @default.
• W2158366771 hasConcept C2780446394 @default.
• W2158366771 hasConcept C44228677 @default.
• W2158366771 hasConcept C521977710 @default.
• W2158366771 hasConcept C71924100 @default.
• W2158366771 hasConceptScore W2158366771C141071460 @default.
• W2158366771 hasConceptScore W2158366771C16005928 @default.
• W2158366771 hasConceptScore W2158366771C178790620 @default.
• W2158366771 hasConceptScore W2158366771C185592680 @default.
• W2158366771 hasConceptScore W2158366771C2777140388 @default.
• W2158366771 hasConceptScore W2158366771C2777673923 @default.
• W2158366771 hasConceptScore W2158366771C2778885487 @default.
• W2158366771 hasConceptScore W2158366771C2780446394 @default.
• W2158366771 hasConceptScore W2158366771C44228677 @default.
• W2158366771 hasConceptScore W2158366771C521977710 @default.
• W2158366771 hasConceptScore W2158366771C71924100 @default.
• W2158366771 hasIssue "6" @default.
• W2158366771 hasLocation W21583667711 @default.
• W2158366771 hasLocation W21583667712 @default.
• W2158366771 hasOpenAccess W2158366771 @default.
• W2158366771 hasPrimaryLocation W21583667711 @default.
• W2158366771 hasRelatedWork W1169053151 @default.
• W2158366771 hasRelatedWork W1940498900 @default.
• W2158366771 hasRelatedWork W1993572006 @default.
• W2158366771 hasRelatedWork W2185568115 @default.
• W2158366771 hasRelatedWork W2521324618 @default.
• W2158366771 hasRelatedWork W2529701582 @default.
• W2158366771 hasRelatedWork W2573390118 @default.
• W2158366771 hasRelatedWork W2976518386 @default.
• W2158366771 hasRelatedWork W4283016225 @default.
• W2158366771 hasRelatedWork W4386407853 @default.
• W2158366771 hasVolume "21" @default.
• W2158366771 isParatext "false" @default.
• W2158366771 isRetracted "false" @default.
• W2158366771 magId "2158366771" @default.
• W2158366771 workType "article" @default.