Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158369873> ?p ?o ?g. }
- W2158369873 endingPage "204" @default.
- W2158369873 startingPage "193" @default.
- W2158369873 abstract "The firm adhesion and transplatelet migration of leukocytes on vascular thrombus are both dependent on the interaction of the leukocyte integrin, Mac-1, and a heretofore unknown platelet counterreceptor. Here, we identify the platelet counterreceptor as glycoprotein (GP) Ibα, a component of the GP Ib-IX-V complex, the platelet von Willebrand factor (vWf) receptor. THP-1 monocytic cells and transfected cells that express Mac-1 adhered to GP Ibα–coated wells. Inhibition studies with monoclonal antibodies or receptor ligands showed that the interaction involves the Mac-1 I domain (homologous to the vWf A1 domain), and the GP Ibα leucine-rich repeat and COOH-terminal flanking regions. The specificity of the interaction was confirmed by the finding that neutrophils from wild-type mice, but not from Mac-1–deficient mice, bound to purified GP Ibα and to adherent platelets, the latter adhesion being inhibited by pretreatment of the platelets with mocarhagin, a protease that specifically cleaves GP Ibα. Finally, immobilized GP Ibα supported the rolling and firm adhesion of THP-1 cells under conditions of flow. These observations provide a molecular target for disrupting leukocyte–platelet complexes that promote vascular inflammation in thrombosis, atherosclerosis, and angioplasty-related restenosis." @default.
- W2158369873 created "2016-06-24" @default.
- W2158369873 creator A5003902141 @default.
- W2158369873 creator A5004301598 @default.
- W2158369873 creator A5018854741 @default.
- W2158369873 creator A5033194571 @default.
- W2158369873 creator A5038643808 @default.
- W2158369873 creator A5041184949 @default.
- W2158369873 creator A5052604218 @default.
- W2158369873 creator A5052875985 @default.
- W2158369873 creator A5065834493 @default.
- W2158369873 creator A5066716873 @default.
- W2158369873 creator A5070821887 @default.
- W2158369873 date "2000-07-10" @default.
- W2158369873 modified "2023-10-17" @default.
- W2158369873 title "Platelet Glycoprotein Ibα Is a Counterreceptor for the Leukocyte Integrin Mac-1 (Cd11b/Cd18)" @default.
- W2158369873 cites W1484320290 @default.
- W2158369873 cites W1498707551 @default.
- W2158369873 cites W1528682116 @default.
- W2158369873 cites W1541073910 @default.
- W2158369873 cites W1572786395 @default.
- W2158369873 cites W1600560134 @default.
- W2158369873 cites W1613698407 @default.
- W2158369873 cites W1670322156 @default.
- W2158369873 cites W1777863255 @default.
- W2158369873 cites W1880636970 @default.
- W2158369873 cites W1897580483 @default.
- W2158369873 cites W1970246174 @default.
- W2158369873 cites W1972470306 @default.
- W2158369873 cites W1974656135 @default.
- W2158369873 cites W1976666984 @default.
- W2158369873 cites W1980576110 @default.
- W2158369873 cites W2002882141 @default.
- W2158369873 cites W2005663928 @default.
- W2158369873 cites W2008130631 @default.
- W2158369873 cites W2010397566 @default.
- W2158369873 cites W2011854883 @default.
- W2158369873 cites W2013123362 @default.
- W2158369873 cites W2013863464 @default.
- W2158369873 cites W2020893836 @default.
- W2158369873 cites W2023693583 @default.
- W2158369873 cites W2028913667 @default.
- W2158369873 cites W2030148186 @default.
- W2158369873 cites W2037690358 @default.
- W2158369873 cites W2037986253 @default.
- W2158369873 cites W2040122658 @default.
- W2158369873 cites W2046628450 @default.
- W2158369873 cites W2066463869 @default.
- W2158369873 cites W2071119634 @default.
- W2158369873 cites W2074981381 @default.
- W2158369873 cites W2075524784 @default.
- W2158369873 cites W2082264161 @default.
- W2158369873 cites W2089625435 @default.
- W2158369873 cites W2093830420 @default.
- W2158369873 cites W2097514615 @default.
- W2158369873 cites W2099675490 @default.
- W2158369873 cites W2107553760 @default.
- W2158369873 cites W2108073192 @default.
- W2158369873 cites W2108093102 @default.
- W2158369873 cites W2108486099 @default.
- W2158369873 cites W2119132855 @default.
- W2158369873 cites W2123695942 @default.
- W2158369873 cites W2125677500 @default.
- W2158369873 cites W2129098607 @default.
- W2158369873 cites W2131547680 @default.
- W2158369873 cites W2136016201 @default.
- W2158369873 cites W2136969158 @default.
- W2158369873 cites W2138819257 @default.
- W2158369873 cites W2152962086 @default.
- W2158369873 cites W2153450942 @default.
- W2158369873 cites W2160378662 @default.
- W2158369873 cites W2163240674 @default.
- W2158369873 cites W2167823330 @default.
- W2158369873 cites W2170684533 @default.
- W2158369873 cites W2230724256 @default.
- W2158369873 cites W2265690186 @default.
- W2158369873 cites W229396605 @default.
- W2158369873 cites W2304120188 @default.
- W2158369873 cites W2324841714 @default.
- W2158369873 cites W2399187687 @default.
- W2158369873 cites W2413224675 @default.
- W2158369873 cites W2413515352 @default.
- W2158369873 cites W2413691447 @default.
- W2158369873 cites W2994044151 @default.
- W2158369873 cites W36951521 @default.
- W2158369873 cites W3880031 @default.
- W2158369873 cites W38970915 @default.
- W2158369873 cites W4229746629 @default.
- W2158369873 cites W4238785086 @default.
- W2158369873 cites W70166318 @default.
- W2158369873 cites W73759871 @default.
- W2158369873 cites W88624808 @default.
- W2158369873 cites W92534390 @default.
- W2158369873 cites W98074226 @default.
- W2158369873 doi "https://doi.org/10.1084/jem.192.2.193" @default.
- W2158369873 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2193258" @default.
- W2158369873 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10899906" @default.
- W2158369873 hasPublicationYear "2000" @default.