FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158376848> ?p ?o ?g. }

• W2158376848 endingPage "1942" @default.
• W2158376848 startingPage "1937" @default.
• W2158376848 abstract "CD8+ T cells have suppressor effector functions, but the mechanisms involved in the generation of this activity are poorly understood. We report that natural killer (NK) cells have an important role in the acquisition of this function. CD8+ cells induce NK cells to produce transforming growth factor-beta (TGF-beta) which, in turn, stimulates CD8+ T cells to become suppressors of antibody production. Using a monocyte-dependent and -independent method to induce antibody production, we first observed that the addition of NK cells to CD8+ cells was required for optimal suppression. Next, we determined that the interaction of CD8+ T cells with NK cells resulted in a striking increase NK cell TGF-beta mRNA and its production. This cytokine appeared to be involved in the induction of T suppressor cell activity since: (a) anti-TGF-beta 1 completely abrogated the suppression of immunoglobulin G synthesis; (b) TGF-beta 1 could substitute for NK cells in inducing CD8+ T cells to develop suppressor activity; and (c) a short exposure of T cells to TGF-beta 1 in the absence of B cells was sufficient for the generation of suppressor activity by CD8+ T cells. Interferon gamma did not have this property. These studies provide strong evidence that in addition to its suppressive properties, TGF-beta is involved in the generation of CD8+ T suppressor effector cells. Because NK cell function is decreased in many autoimmune diseases, these cells may fail to interact properly with these individuals' CD8+ cells in generating suppressors of aggressive anti-self responses." @default.
• W2158376848 created "2016-06-24" @default.
• W2158376848 creator A5007933806 @default.
• W2158376848 creator A5087780421 @default.
• W2158376848 creator A5089115356 @default.
• W2158376848 date "1994-11-01" @default.
• W2158376848 modified "2023-09-24" @default.
• W2158376848 title "The role of transforming growth factor beta in the generation of suppression: an interaction between CD8+ T and NK cells." @default.
• W2158376848 cites W1489242933 @default.
• W2158376848 cites W1546377462 @default.
• W2158376848 cites W1547565061 @default.
• W2158376848 cites W1559971535 @default.
• W2158376848 cites W1588270487 @default.
• W2158376848 cites W1594069877 @default.
• W2158376848 cites W1604685496 @default.
• W2158376848 cites W1605241473 @default.
• W2158376848 cites W1677298903 @default.
• W2158376848 cites W1913814259 @default.
• W2158376848 cites W1915540322 @default.
• W2158376848 cites W1966333025 @default.
• W2158376848 cites W1976213001 @default.
• W2158376848 cites W1987794000 @default.
• W2158376848 cites W1987871130 @default.
• W2158376848 cites W199389074 @default.
• W2158376848 cites W2005785652 @default.
• W2158376848 cites W2027366621 @default.
• W2158376848 cites W2031941127 @default.
• W2158376848 cites W2041714572 @default.
• W2158376848 cites W2043759777 @default.
• W2158376848 cites W2044069347 @default.
• W2158376848 cites W2044214272 @default.
• W2158376848 cites W2074958744 @default.
• W2158376848 cites W2076843743 @default.
• W2158376848 cites W2101835477 @default.
• W2158376848 cites W2132196752 @default.
• W2158376848 cites W2136819827 @default.
• W2158376848 cites W2416270034 @default.
• W2158376848 doi "https://doi.org/10.1084/jem.180.5.1937" @default.
• W2158376848 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2191718" @default.
• W2158376848 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7964469" @default.
• W2158376848 hasPublicationYear "1994" @default.
• W2158376848 type Work @default.
• W2158376848 sameAs 2158376848 @default.
• W2158376848 citedByCount "139" @default.
• W2158376848 countsByYear W21583768482012 @default.
• W2158376848 countsByYear W21583768482013 @default.
• W2158376848 countsByYear W21583768482016 @default.
• W2158376848 countsByYear W21583768482017 @default.
• W2158376848 countsByYear W21583768482018 @default.
• W2158376848 countsByYear W21583768482019 @default.
• W2158376848 countsByYear W21583768482020 @default.
• W2158376848 countsByYear W21583768482021 @default.
• W2158376848 countsByYear W21583768482022 @default.
• W2158376848 countsByYear W21583768482023 @default.
• W2158376848 crossrefType "journal-article" @default.
• W2158376848 hasAuthorship W2158376848A5007933806 @default.
• W2158376848 hasAuthorship W2158376848A5087780421 @default.
• W2158376848 hasAuthorship W2158376848A5089115356 @default.
• W2158376848 hasBestOaLocation W21583768481 @default.
• W2158376848 hasConcept C118131993 @default.
• W2158376848 hasConcept C129374314 @default.
• W2158376848 hasConcept C139563560 @default.
• W2158376848 hasConcept C149532602 @default.
• W2158376848 hasConcept C154317977 @default.
• W2158376848 hasConcept C167672396 @default.
• W2158376848 hasConcept C202751555 @default.
• W2158376848 hasConcept C203014093 @default.
• W2158376848 hasConcept C2778229498 @default.
• W2158376848 hasConcept C2778690821 @default.
• W2158376848 hasConcept C39347974 @default.
• W2158376848 hasConcept C55493867 @default.
• W2158376848 hasConcept C86803240 @default.
• W2158376848 hasConcept C8891405 @default.
• W2158376848 hasConcept C95444343 @default.
• W2158376848 hasConceptScore W2158376848C118131993 @default.
• W2158376848 hasConceptScore W2158376848C129374314 @default.
• W2158376848 hasConceptScore W2158376848C139563560 @default.
• W2158376848 hasConceptScore W2158376848C149532602 @default.
• W2158376848 hasConceptScore W2158376848C154317977 @default.
• W2158376848 hasConceptScore W2158376848C167672396 @default.
• W2158376848 hasConceptScore W2158376848C202751555 @default.
• W2158376848 hasConceptScore W2158376848C203014093 @default.
• W2158376848 hasConceptScore W2158376848C2778229498 @default.
• W2158376848 hasConceptScore W2158376848C2778690821 @default.
• W2158376848 hasConceptScore W2158376848C39347974 @default.
• W2158376848 hasConceptScore W2158376848C55493867 @default.
• W2158376848 hasConceptScore W2158376848C86803240 @default.
• W2158376848 hasConceptScore W2158376848C8891405 @default.
• W2158376848 hasConceptScore W2158376848C95444343 @default.
• W2158376848 hasIssue "5" @default.
• W2158376848 hasLocation W21583768481 @default.
• W2158376848 hasLocation W21583768482 @default.
• W2158376848 hasLocation W21583768483 @default.
• W2158376848 hasLocation W21583768484 @default.
• W2158376848 hasOpenAccess W2158376848 @default.
• W2158376848 hasPrimaryLocation W21583768481 @default.
• W2158376848 hasRelatedWork W1991655492 @default.
• W2158376848 hasRelatedWork W2002809032 @default.

• next