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- W2158403894 endingPage "16" @default.
- W2158403894 startingPage "3" @default.
- W2158403894 abstract "Small RNAs are a commonly used tool for gene silencing and a promising platform for nucleic acid drug development. They are almost exclusively used to silence gene expression post-transcriptionally through degradation of mRNA. Small RNAs, however, can have a broader range of function by binding to Argonaute proteins and associating with complementary RNA targets in the nucleus, including long noncoding RNAs (lncRNAs) and pre-mRNA. Argonaute–RNA complexes can regulate nuclear events like transcription, genome maintenance, and splicing. Thousands of lncRNAs and alternatively spliced pre-mRNA isoforms exist in humans, and these RNAs may serve as natural targets for regulation and therapeutic intervention. This review describes nuclear mechanisms for Argonaute proteins and small RNAs, new pathways for sequence-specific targeting, and the potential for therapeutic development of small RNAs with nuclear targets." @default.
- W2158403894 created "2016-06-24" @default.
- W2158403894 creator A5044865944 @default.
- W2158403894 creator A5067386364 @default.
- W2158403894 date "2012-02-01" @default.
- W2158403894 modified "2023-09-30" @default.
- W2158403894 title "Argonaute and the Nuclear RNAs: New Pathways for RNA-Mediated Control of Gene Expression" @default.
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