FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158409519> ?p ?o ?g. }

• W2158409519 endingPage "1139" @default.
• W2158409519 startingPage "1132" @default.
• W2158409519 abstract "Uterine vascular tone significantly decreases whereas uterine blood flow dramatically increases during pregnancy. However, the complete molecular mechanisms remain elusive. We hypothesized that increased Ca(2+)-activated K(+) (BK(Ca)) channel activity contributes to the decreased myogenic tone of uterine arteries in pregnancy. Resistance-sized uterine arteries were isolated from nonpregnant and near-term pregnant sheep. Electrophysiological studies revealed a greater whole-cell K(+) current density in pregnant compared with nonpregnant uterine arteries. Tetraethylammonium and iberiotoxin inhibited K(+) currents to the same extent in uterine arterial myocytes. The BK(Ca) channel current density was significantly increased in pregnant uterine arteries. In accordance, tetraethylammonium significantly increased pressure-induced myogenic tone in pregnant uterine arteries and abolished the difference in myogenic responses between pregnant and nonpregnant uterine arteries. Activation of protein kinase C produced a similar effect to tetraethylammonium by inhibiting BK(Ca) channel activity and increasing myogenic tone in pregnant uterine arteries. Chronic treatment of nonpregnant uterine arteries with physiologically relevant concentrations of 17β-estradiol and progesterone caused a significant increase in the BK(Ca) channel current density. Western blot analyses demonstrated a significant increase of the β1, but not α, subunit of BK(Ca) channels in pregnant uterine arteries. In accordance, steroid treatment of nonpregnant uterine arteries resulted in an upregulation of the β1, but not α, subunit expression. The results indicate that the steroid hormone-mediated upregulation of the β1 subunit and BK(Ca) channel activity may play a key role in attenuating myogenic tone of the uterine artery in pregnancy." @default.
• W2158409519 created "2016-06-24" @default.
• W2158409519 creator A5003198184 @default.
• W2158409519 creator A5012635924 @default.
• W2158409519 creator A5026111925 @default.
• W2158409519 creator A5066716873 @default.
• W2158409519 creator A5077546996 @default.
• W2158409519 creator A5079159103 @default.
• W2158409519 creator A5089249330 @default.
• W2158409519 date "2011-12-01" @default.
• W2158409519 modified "2023-10-17" @default.
• W2158409519 title "Pregnancy Upregulates Large-Conductance Ca ²⁺ -Activated K ⁺ Channel Activity and Attenuates Myogenic Tone in Uterine Arteries" @default.
• W2158409519 cites W134363133 @default.
• W2158409519 cites W1519345480 @default.
• W2158409519 cites W159128481 @default.
• W2158409519 cites W1739498942 @default.
• W2158409519 cites W1753089048 @default.
• W2158409519 cites W2000117155 @default.
• W2158409519 cites W2020214165 @default.
• W2158409519 cites W2022013418 @default.
• W2158409519 cites W2023072981 @default.
• W2158409519 cites W2027315787 @default.
• W2158409519 cites W2029489419 @default.
• W2158409519 cites W2030669443 @default.
• W2158409519 cites W2043563682 @default.
• W2158409519 cites W2050296008 @default.
• W2158409519 cites W2050391893 @default.
• W2158409519 cites W2058241653 @default.
• W2158409519 cites W2071969879 @default.
• W2158409519 cites W2101722224 @default.
• W2158409519 cites W2110106415 @default.
• W2158409519 cites W2111692777 @default.
• W2158409519 cites W2114965183 @default.
• W2158409519 cites W2117522857 @default.
• W2158409519 cites W2118142275 @default.
• W2158409519 cites W2119683663 @default.
• W2158409519 cites W2121977758 @default.
• W2158409519 cites W2122995536 @default.
• W2158409519 cites W2126046035 @default.
• W2158409519 cites W2128400434 @default.
• W2158409519 cites W2130986258 @default.
• W2158409519 cites W2146631372 @default.
• W2158409519 cites W2149635665 @default.
• W2158409519 cites W2151472389 @default.
• W2158409519 cites W2151685833 @default.
• W2158409519 cites W2159462548 @default.
• W2158409519 cites W2164566530 @default.
• W2158409519 cites W2168820902 @default.
• W2158409519 cites W2169533453 @default.
• W2158409519 cites W2188140301 @default.
• W2158409519 cites W2190434307 @default.
• W2158409519 cites W2239050330 @default.
• W2158409519 cites W4250397360 @default.
• W2158409519 doi "https://doi.org/10.1161/hypertensionaha.111.179952" @default.
• W2158409519 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3223357" @default.
• W2158409519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22042813" @default.
• W2158409519 hasPublicationYear "2011" @default.
• W2158409519 type Work @default.
• W2158409519 sameAs 2158409519 @default.
• W2158409519 citedByCount "75" @default.
• W2158409519 countsByYear W21584095192012 @default.
• W2158409519 countsByYear W21584095192013 @default.
• W2158409519 countsByYear W21584095192014 @default.
• W2158409519 countsByYear W21584095192015 @default.
• W2158409519 countsByYear W21584095192016 @default.
• W2158409519 countsByYear W21584095192017 @default.
• W2158409519 countsByYear W21584095192018 @default.
• W2158409519 countsByYear W21584095192019 @default.
• W2158409519 countsByYear W21584095192020 @default.
• W2158409519 countsByYear W21584095192021 @default.
• W2158409519 countsByYear W21584095192022 @default.
• W2158409519 countsByYear W21584095192023 @default.
• W2158409519 crossrefType "journal-article" @default.
• W2158409519 hasAuthorship W2158409519A5003198184 @default.
• W2158409519 hasAuthorship W2158409519A5012635924 @default.
• W2158409519 hasAuthorship W2158409519A5026111925 @default.
• W2158409519 hasAuthorship W2158409519A5066716873 @default.
• W2158409519 hasAuthorship W2158409519A5077546996 @default.
• W2158409519 hasAuthorship W2158409519A5079159103 @default.
• W2158409519 hasAuthorship W2158409519A5089249330 @default.
• W2158409519 hasBestOaLocation W21584095191 @default.
• W2158409519 hasConcept C126322002 @default.
• W2158409519 hasConcept C134018914 @default.
• W2158409519 hasConcept C172680121 @default.
• W2158409519 hasConcept C178790620 @default.
• W2158409519 hasConcept C185592680 @default.
• W2158409519 hasConcept C2776953305 @default.
• W2158409519 hasConcept C2777663904 @default.
• W2158409519 hasConcept C2778164554 @default.
• W2158409519 hasConcept C2779066055 @default.
• W2158409519 hasConcept C2779234561 @default.
• W2158409519 hasConcept C2779395532 @default.
• W2158409519 hasConcept C2781207646 @default.
• W2158409519 hasConcept C2781295685 @default.
• W2158409519 hasConcept C2992686903 @default.
• W2158409519 hasConcept C46973012 @default.
• W2158409519 hasConcept C517785266 @default.
• W2158409519 hasConcept C54355233 @default.

• next