FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158409975> ?p ?o ?g. }

• W2158409975 endingPage "1702" @default.
• W2158409975 startingPage "1693" @default.
• W2158409975 abstract "BACKGROUND Zinc transporter 8 (ZnT8) is a recently identified major autoantigen in type 1 diabetes, and autoantibodies to ZnT8 (ZnT8A) are new markers for disease prediction and diagnosis. Here we report the results of the first international proficiency evaluation of ZnT8A assays by the Diabetes Antibody Standardization Program (DASP). METHODS After a pilot workshop in 2007, an expanded ZnT8A workshop was held in 2009, with 26 participating laboratories from 13 countries submitting results of 63 different assays. ZnT8A levels were measured in coded sera from 50 patients with newly diagnosed type 1 diabetes and 100 blood donor controls. Results were analyzed comparing area under the ROC curve (ROC-AUC), sensitivity adjusted to 95% specificity (AS95), concordance of sample ZnT8A positive or negative designation, and autoantibody levels. RESULTS ZnT8A radio binding assays (RBAs) based on combined immunoprecipitation of the 2 most frequent ZnT8 COOH-terminal domain polymorphic variants showed a median ROC-AUC of 0.848 [interquartile range (IQR) 0.796–0.878] and a median AS95 of 70% (IQR 60%–72%). These RBAs were more sensitive than assays using as antigen either 1 ZnT8 variant only or chimeric constructs joining NH2- and COOH-terminal domains, assays based on immunoprecipitation and bioluminescent detection, or assays based on immunofluorescent staining of cells transfected with full-length antigen. CONCLUSIONS The DASP workshop identified immunoprecipitation-based ZnT8A assays and antigen constructs that achieved both a high degree of sensitivity and specificity and were suitable for more widespread clinical application." @default.
• W2158409975 created "2016-06-24" @default.
• W2158409975 creator A5011573488 @default.
• W2158409975 creator A5025489705 @default.
• W2158409975 creator A5028741505 @default.
• W2158409975 creator A5051724531 @default.
• W2158409975 creator A5058744766 @default.
• W2158409975 creator A5061340857 @default.
• W2158409975 creator A5066326862 @default.
• W2158409975 creator A5081946880 @default.
• W2158409975 date "2011-12-01" @default.
• W2158409975 modified "2023-10-18" @default.
• W2158409975 title "Diabetes Antibody Standardization Program: First Proficiency Evaluation of Assays for Autoantibodies to Zinc Transporter 8" @default.
• W2158409975 cites W1965253904 @default.
• W2158409975 cites W1965800980 @default.
• W2158409975 cites W1969691202 @default.
• W2158409975 cites W1975879668 @default.
• W2158409975 cites W1976066308 @default.
• W2158409975 cites W1989257844 @default.
• W2158409975 cites W1993312496 @default.
• W2158409975 cites W1993779561 @default.
• W2158409975 cites W1996290308 @default.
• W2158409975 cites W2008443993 @default.
• W2158409975 cites W2013359164 @default.
• W2158409975 cites W2033474350 @default.
• W2158409975 cites W2034298939 @default.
• W2158409975 cites W2042079719 @default.
• W2158409975 cites W2045260557 @default.
• W2158409975 cites W2065017807 @default.
• W2158409975 cites W2076061140 @default.
• W2158409975 cites W2076342192 @default.
• W2158409975 cites W2083754730 @default.
• W2158409975 cites W2091765481 @default.
• W2158409975 cites W2098742390 @default.
• W2158409975 cites W2122628406 @default.
• W2158409975 cites W2129551653 @default.
• W2158409975 cites W2155379679 @default.
• W2158409975 cites W2163682242 @default.
• W2158409975 doi "https://doi.org/10.1373/clinchem.2011.170662" @default.
• W2158409975 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21980171" @default.
• W2158409975 hasPublicationYear "2011" @default.
• W2158409975 type Work @default.
• W2158409975 sameAs 2158409975 @default.
• W2158409975 citedByCount "98" @default.
• W2158409975 countsByYear W21584099752012 @default.
• W2158409975 countsByYear W21584099752013 @default.
• W2158409975 countsByYear W21584099752014 @default.
• W2158409975 countsByYear W21584099752015 @default.
• W2158409975 countsByYear W21584099752016 @default.
• W2158409975 countsByYear W21584099752017 @default.
• W2158409975 countsByYear W21584099752018 @default.
• W2158409975 countsByYear W21584099752019 @default.
• W2158409975 countsByYear W21584099752020 @default.
• W2158409975 countsByYear W21584099752021 @default.
• W2158409975 countsByYear W21584099752022 @default.
• W2158409975 countsByYear W21584099752023 @default.
• W2158409975 crossrefType "journal-article" @default.
• W2158409975 hasAuthorship W2158409975A5011573488 @default.
• W2158409975 hasAuthorship W2158409975A5025489705 @default.
• W2158409975 hasAuthorship W2158409975A5028741505 @default.
• W2158409975 hasAuthorship W2158409975A5051724531 @default.
• W2158409975 hasAuthorship W2158409975A5058744766 @default.
• W2158409975 hasAuthorship W2158409975A5061340857 @default.
• W2158409975 hasAuthorship W2158409975A5066326862 @default.
• W2158409975 hasAuthorship W2158409975A5081946880 @default.
• W2158409975 hasBestOaLocation W21584099751 @default.
• W2158409975 hasConcept C119060515 @default.
• W2158409975 hasConcept C126322002 @default.
• W2158409975 hasConcept C147483822 @default.
• W2158409975 hasConcept C159654299 @default.
• W2158409975 hasConcept C160798450 @default.
• W2158409975 hasConcept C163764329 @default.
• W2158409975 hasConcept C203014093 @default.
• W2158409975 hasConcept C58471807 @default.
• W2158409975 hasConcept C71924100 @default.
• W2158409975 hasConceptScore W2158409975C119060515 @default.
• W2158409975 hasConceptScore W2158409975C126322002 @default.
• W2158409975 hasConceptScore W2158409975C147483822 @default.
• W2158409975 hasConceptScore W2158409975C159654299 @default.
• W2158409975 hasConceptScore W2158409975C160798450 @default.
• W2158409975 hasConceptScore W2158409975C163764329 @default.
• W2158409975 hasConceptScore W2158409975C203014093 @default.
• W2158409975 hasConceptScore W2158409975C58471807 @default.
• W2158409975 hasConceptScore W2158409975C71924100 @default.
• W2158409975 hasFunder F4320310820 @default.
• W2158409975 hasFunder F4320320300 @default.
• W2158409975 hasFunder F4320332161 @default.
• W2158409975 hasFunder F4320332162 @default.
• W2158409975 hasIssue "12" @default.
• W2158409975 hasLocation W21584099751 @default.
• W2158409975 hasLocation W21584099752 @default.
• W2158409975 hasOpenAccess W2158409975 @default.
• W2158409975 hasPrimaryLocation W21584099751 @default.
• W2158409975 hasRelatedWork W178914116 @default.
• W2158409975 hasRelatedWork W1998792271 @default.
• W2158409975 hasRelatedWork W2061253854 @default.
• W2158409975 hasRelatedWork W2400506786 @default.
• W2158409975 hasRelatedWork W2409020744 @default.

• next