FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158429225> ?p ?o ?g. }

• W2158429225 endingPage "e1004172" @default.
• W2158429225 startingPage "e1004172" @default.
• W2158429225 abstract "During development, animals usually undergo a rapid growth phase followed by a homeostatic stage when growth has ceased. The increase in cell size and number during the growth phase requires a large amount of lipids; while in the static state, excess lipids are usually stored in adipose tissues in preparation for nutrient-limited conditions. How cells coordinate growth and fat storage is not fully understood. Through a genetic screen we identified Drosophila melanogaster CDP-diacylglycerol synthetase (CDS/CdsA), which diverts phosphatidic acid from triacylglycerol synthesis to phosphatidylinositol (PI) synthesis and coordinates cell growth and fat storage. Loss of CdsA function causes significant accumulation of neutral lipids in many tissues along with reduced cell/organ size. These phenotypes can be traced back to reduced PI levels and, subsequently, low insulin pathway activity. Overexpressing CdsA rescues the fat storage and cell growth phenotypes of insulin pathway mutants, suggesting that CdsA coordinates cell/tissue growth and lipid storage through the insulin pathway. We also revealed that a DAG-to-PE route mediated by the choline/ethanolamine phosphotransferase Bbc may contribute to the growth of fat cells in CdsA RNAi." @default.
• W2158429225 created "2016-06-24" @default.
• W2158429225 creator A5039968611 @default.
• W2158429225 creator A5046597133 @default.
• W2158429225 creator A5090674310 @default.
• W2158429225 creator A5091105051 @default.
• W2158429225 date "2014-03-06" @default.
• W2158429225 modified "2023-09-23" @default.
• W2158429225 title "CDP-Diacylglycerol Synthetase Coordinates Cell Growth and Fat Storage through Phosphatidylinositol Metabolism and the Insulin Pathway" @default.
• W2158429225 cites W1965414585 @default.
• W2158429225 cites W1969429227 @default.
• W2158429225 cites W1976405498 @default.
• W2158429225 cites W1977869829 @default.
• W2158429225 cites W1998693406 @default.
• W2158429225 cites W2010028774 @default.
• W2158429225 cites W2010689036 @default.
• W2158429225 cites W2010905069 @default.
• W2158429225 cites W2014560331 @default.
• W2158429225 cites W2014887370 @default.
• W2158429225 cites W2016752484 @default.
• W2158429225 cites W2025851393 @default.
• W2158429225 cites W2026412213 @default.
• W2158429225 cites W2031078895 @default.
• W2158429225 cites W2033682352 @default.
• W2158429225 cites W2036204652 @default.
• W2158429225 cites W2051178873 @default.
• W2158429225 cites W2053073281 @default.
• W2158429225 cites W2065293842 @default.
• W2158429225 cites W2071203725 @default.
• W2158429225 cites W2076684078 @default.
• W2158429225 cites W2076785505 @default.
• W2158429225 cites W2082966250 @default.
• W2158429225 cites W2085900248 @default.
• W2158429225 cites W2086102771 @default.
• W2158429225 cites W2086829676 @default.
• W2158429225 cites W2087723496 @default.
• W2158429225 cites W2088782756 @default.
• W2158429225 cites W2097185162 @default.
• W2158429225 cites W2103141455 @default.
• W2158429225 cites W2110096767 @default.
• W2158429225 cites W2114713612 @default.
• W2158429225 cites W2116068694 @default.
• W2158429225 cites W2120999458 @default.
• W2158429225 cites W2127063807 @default.
• W2158429225 cites W2128607432 @default.
• W2158429225 cites W2130016382 @default.
• W2158429225 cites W2130505586 @default.
• W2158429225 cites W2131844826 @default.
• W2158429225 cites W2141884202 @default.
• W2158429225 cites W2143657346 @default.
• W2158429225 cites W2145029774 @default.
• W2158429225 cites W2148070562 @default.
• W2158429225 cites W2165192354 @default.
• W2158429225 cites W2168734886 @default.
• W2158429225 cites W2171665800 @default.
• W2158429225 doi "https://doi.org/10.1371/journal.pgen.1004172" @default.
• W2158429225 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3945474" @default.
• W2158429225 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24603715" @default.
• W2158429225 hasPublicationYear "2014" @default.
• W2158429225 type Work @default.
• W2158429225 sameAs 2158429225 @default.
• W2158429225 citedByCount "41" @default.
• W2158429225 countsByYear W21584292252015 @default.
• W2158429225 countsByYear W21584292252016 @default.
• W2158429225 countsByYear W21584292252017 @default.
• W2158429225 countsByYear W21584292252018 @default.
• W2158429225 countsByYear W21584292252019 @default.
• W2158429225 countsByYear W21584292252020 @default.
• W2158429225 countsByYear W21584292252021 @default.
• W2158429225 countsByYear W21584292252022 @default.
• W2158429225 countsByYear W21584292252023 @default.
• W2158429225 crossrefType "journal-article" @default.
• W2158429225 hasAuthorship W2158429225A5039968611 @default.
• W2158429225 hasAuthorship W2158429225A5046597133 @default.
• W2158429225 hasAuthorship W2158429225A5090674310 @default.
• W2158429225 hasAuthorship W2158429225A5091105051 @default.
• W2158429225 hasBestOaLocation W21584292251 @default.
• W2158429225 hasConcept C171089720 @default.
• W2158429225 hasConcept C195794163 @default.
• W2158429225 hasConcept C2776909261 @default.
• W2158429225 hasConcept C2778918659 @default.
• W2158429225 hasConcept C2780610907 @default.
• W2158429225 hasConcept C36020004 @default.
• W2158429225 hasConcept C41625074 @default.
• W2158429225 hasConcept C4733338 @default.
• W2158429225 hasConcept C55493867 @default.
• W2158429225 hasConcept C62112901 @default.
• W2158429225 hasConcept C62478195 @default.
• W2158429225 hasConcept C86803240 @default.
• W2158429225 hasConcept C95444343 @default.
• W2158429225 hasConceptScore W2158429225C171089720 @default.
• W2158429225 hasConceptScore W2158429225C195794163 @default.
• W2158429225 hasConceptScore W2158429225C2776909261 @default.
• W2158429225 hasConceptScore W2158429225C2778918659 @default.
• W2158429225 hasConceptScore W2158429225C2780610907 @default.
• W2158429225 hasConceptScore W2158429225C36020004 @default.
• W2158429225 hasConceptScore W2158429225C41625074 @default.
• W2158429225 hasConceptScore W2158429225C4733338 @default.

• next