Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158431133> ?p ?o ?g. }
- W2158431133 endingPage "851" @default.
- W2158431133 startingPage "833" @default.
- W2158431133 abstract "The Leishmania donovani glycoprotein fraction, known as FML, successfully underwent preclinical and clinical (Phase I–III) vaccine trials against canine visceral leishmaniasis (92–95% of protection and 76–80% of vaccine efficacy) when formulated with a QS21 saponin-containing adjuvant. It became the licensed Leishmune® vaccine for canine prophylaxis in Brazil. The immune response raised by the vaccine is long lasting, immunotherapeutic and reduces dog infectivity blocking the transmission of the disease, as revealed by an in vivo assay. The preliminary epidemiological control data of vaccinated areas in Brazil indicate that, in spite of the still low vaccine coverage, there was a significant decrease in the incidence of the human and canine disease. A 36-kDa glycoprotein, in the FML complex, is the human marker of the disease, which was protective in mice as native recombinant protein or DNA vaccine. The DNA vaccine is now being tested against the canine disease. This review resumes the development of the second-generation FML–saponin–Leishmune vaccine, its adjuvant and of the NH36 DNA vaccine, toward the identification of its major epitopes that might be included in a possible future synthetic vaccine." @default.
- W2158431133 created "2016-06-24" @default.
- W2158431133 creator A5008710671 @default.
- W2158431133 creator A5023915808 @default.
- W2158431133 creator A5057912164 @default.
- W2158431133 creator A5062187167 @default.
- W2158431133 creator A5080760688 @default.
- W2158431133 creator A5083591717 @default.
- W2158431133 creator A5085826549 @default.
- W2158431133 creator A5087775439 @default.
- W2158431133 creator A5050735769 @default.
- W2158431133 date "2008-08-01" @default.
- W2158431133 modified "2023-09-27" @default.
- W2158431133 title "FML vaccine against canine visceral leishmaniasis: from second-generation to synthetic vaccine" @default.
- W2158431133 cites W113394840 @default.
- W2158431133 cites W116276269 @default.
- W2158431133 cites W1490261874 @default.
- W2158431133 cites W1501665702 @default.
- W2158431133 cites W1508999422 @default.
- W2158431133 cites W168570288 @default.
- W2158431133 cites W1840052409 @default.
- W2158431133 cites W1882062365 @default.
- W2158431133 cites W1898975856 @default.
- W2158431133 cites W1922307675 @default.
- W2158431133 cites W1943630073 @default.
- W2158431133 cites W1950404159 @default.
- W2158431133 cites W1963105351 @default.
- W2158431133 cites W1966025717 @default.
- W2158431133 cites W1967165009 @default.
- W2158431133 cites W1967769777 @default.
- W2158431133 cites W1968253395 @default.
- W2158431133 cites W1968292510 @default.
- W2158431133 cites W1969819979 @default.
- W2158431133 cites W1970018969 @default.
- W2158431133 cites W1974444664 @default.
- W2158431133 cites W1974652725 @default.
- W2158431133 cites W1975855231 @default.
- W2158431133 cites W1979225504 @default.
- W2158431133 cites W1979482928 @default.
- W2158431133 cites W1979724408 @default.
- W2158431133 cites W1980581925 @default.
- W2158431133 cites W1980933293 @default.
- W2158431133 cites W1984316970 @default.
- W2158431133 cites W1984356802 @default.
- W2158431133 cites W1984665950 @default.
- W2158431133 cites W1986782495 @default.
- W2158431133 cites W1987254502 @default.
- W2158431133 cites W1993338105 @default.
- W2158431133 cites W1993944869 @default.
- W2158431133 cites W1994345083 @default.
- W2158431133 cites W1994437514 @default.
- W2158431133 cites W2002921302 @default.
- W2158431133 cites W2003339749 @default.
- W2158431133 cites W2008959284 @default.
- W2158431133 cites W2011273365 @default.
- W2158431133 cites W2012005099 @default.
- W2158431133 cites W2012172250 @default.
- W2158431133 cites W2016101999 @default.
- W2158431133 cites W2020508488 @default.
- W2158431133 cites W2021578543 @default.
- W2158431133 cites W2021712302 @default.
- W2158431133 cites W2025369790 @default.
- W2158431133 cites W2027128438 @default.
- W2158431133 cites W2028354883 @default.
- W2158431133 cites W2037009713 @default.
- W2158431133 cites W2039077381 @default.
- W2158431133 cites W2039786096 @default.
- W2158431133 cites W2049295129 @default.
- W2158431133 cites W2050886892 @default.
- W2158431133 cites W2051703773 @default.
- W2158431133 cites W2053293487 @default.
- W2158431133 cites W2057475082 @default.
- W2158431133 cites W2058521929 @default.
- W2158431133 cites W2059255792 @default.
- W2158431133 cites W2063102134 @default.
- W2158431133 cites W2064551230 @default.
- W2158431133 cites W2066340987 @default.
- W2158431133 cites W2075501306 @default.
- W2158431133 cites W2077316523 @default.
- W2158431133 cites W2078427852 @default.
- W2158431133 cites W2080146117 @default.
- W2158431133 cites W2080951592 @default.
- W2158431133 cites W2082059586 @default.
- W2158431133 cites W2086882485 @default.
- W2158431133 cites W2086938562 @default.
- W2158431133 cites W2087203114 @default.
- W2158431133 cites W2095331802 @default.
- W2158431133 cites W2099814937 @default.
- W2158431133 cites W2103080556 @default.
- W2158431133 cites W2103233028 @default.
- W2158431133 cites W2104643105 @default.
- W2158431133 cites W2105423532 @default.
- W2158431133 cites W2106378467 @default.
- W2158431133 cites W2112941009 @default.
- W2158431133 cites W2113019075 @default.
- W2158431133 cites W2113874191 @default.
- W2158431133 cites W2123335590 @default.
- W2158431133 cites W2124500686 @default.