FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158431570> ?p ?o ?g. }

• W2158431570 endingPage "3483" @default.
• W2158431570 startingPage "3469" @default.
• W2158431570 abstract "Chronic cardiac allograft rejection presents pathologically as graft arteriosclerosis (GA) characterized by recipient T cell and monocyte infiltration. To determine whether oligoclonal T cells are present in coronary arteries of cardiac allografts from patients with GA, we conducted sequencing analysis of beta-chain TCR transcripts from these explanted coronary arteries using the nonpalindromic adaptor-PCR. Substantial proportions of identical beta-chain TCR transcripts in three of five patients were observed, clearly demonstrating the presence of oligoclonal T cells. TCR transcripts from the arteries of two other patients were relative heterogeneous. High proportions of identical CDR3 beta-chain TCR motifs were found in each patient. GENEBANK/EMBL/SWISS PROT database comparison of all sequences revealed that these beta-chain TCR transcripts were novel. Using Vbeta-specific PCR (independent amplification), we found in patient GA03 that the TCR transcript that was clonally expanded in the left anterior descending artery after nonpalindromic adaptor-PCR was also clonally expanded in the right coronary artery of the same allograft. These results demonstrate that this TCR transcript was clonally expanded at different anatomic sides of the cardiac allograft in a systemic manner. In two patients identical beta-chain TCR transcripts that were found to be clonally expanded in the coronary arteries of their explanted cardiac allografts were also found to be clonally explanted in endomyocardial biopsies collected 17 and 21 mo earlier from each patient. The presence of oligoclonal populations of T cells in the rejected graft suggest that these T cells have undergone specific Ag-driven proliferation and clonal expansion early on within the graft and persist throughout the post-transplantation period." @default.
• W2158431570 created "2016-06-24" @default.
• W2158431570 creator A5030021861 @default.
• W2158431570 creator A5047455011 @default.
• W2158431570 creator A5064491810 @default.
• W2158431570 creator A5066760659 @default.
• W2158431570 creator A5087602962 @default.
• W2158431570 date "2000-09-15" @default.
• W2158431570 modified "2023-10-01" @default.
• W2158431570 title "Coronary Arteries from Human Cardiac Allografts with Chronic Rejection Contain Oligoclonal T Cells: Persistence of Identical Clonally Expanded TCR Transcripts from the Early Post-Transplantation Period (Endomyocardial Biopsies) to Chronic Rejection (Coronary Arteries)" @default.
• W2158431570 cites W1544225130 @default.
• W2158431570 cites W1559824655 @default.
• W2158431570 cites W1566033696 @default.
• W2158431570 cites W1567730870 @default.
• W2158431570 cites W1889889863 @default.
• W2158431570 cites W1910096341 @default.
• W2158431570 cites W1965045795 @default.
• W2158431570 cites W1965945233 @default.
• W2158431570 cites W1973105234 @default.
• W2158431570 cites W1974448548 @default.
• W2158431570 cites W1980900068 @default.
• W2158431570 cites W1984965236 @default.
• W2158431570 cites W1993442513 @default.
• W2158431570 cites W1994407026 @default.
• W2158431570 cites W1995593914 @default.
• W2158431570 cites W1999995106 @default.
• W2158431570 cites W2000620661 @default.
• W2158431570 cites W2001594378 @default.
• W2158431570 cites W2012447761 @default.
• W2158431570 cites W2014179331 @default.
• W2158431570 cites W2015648119 @default.
• W2158431570 cites W2016835779 @default.
• W2158431570 cites W2018492373 @default.
• W2158431570 cites W2018769508 @default.
• W2158431570 cites W2025112879 @default.
• W2158431570 cites W2031209863 @default.
• W2158431570 cites W2032891517 @default.
• W2158431570 cites W2033592208 @default.
• W2158431570 cites W2035881418 @default.
• W2158431570 cites W2036039626 @default.
• W2158431570 cites W2037999444 @default.
• W2158431570 cites W2039047053 @default.
• W2158431570 cites W2039064209 @default.
• W2158431570 cites W2043763796 @default.
• W2158431570 cites W2044316391 @default.
• W2158431570 cites W2048235159 @default.
• W2158431570 cites W2052155865 @default.
• W2158431570 cites W2055111376 @default.
• W2158431570 cites W2057673864 @default.
• W2158431570 cites W2057852327 @default.
• W2158431570 cites W2058350006 @default.
• W2158431570 cites W2060985228 @default.
• W2158431570 cites W2076923050 @default.
• W2158431570 cites W2079380877 @default.
• W2158431570 cites W2082192422 @default.
• W2158431570 cites W2085296338 @default.
• W2158431570 cites W2088477504 @default.
• W2158431570 cites W2101211522 @default.
• W2158431570 cites W2116948093 @default.
• W2158431570 cites W2121829647 @default.
• W2158431570 cites W2127293742 @default.
• W2158431570 cites W2129894977 @default.
• W2158431570 cites W2130757986 @default.
• W2158431570 cites W2132417094 @default.
• W2158431570 cites W2134104296 @default.
• W2158431570 cites W2143330294 @default.
• W2158431570 cites W2144700815 @default.
• W2158431570 cites W2154033753 @default.
• W2158431570 cites W2155904199 @default.
• W2158431570 cites W2156371436 @default.
• W2158431570 cites W2157417177 @default.
• W2158431570 cites W2163357710 @default.
• W2158431570 cites W2165344718 @default.
• W2158431570 doi "https://doi.org/10.4049/jimmunol.165.6.3469" @default.
• W2158431570 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10975868" @default.
• W2158431570 hasPublicationYear "2000" @default.
• W2158431570 type Work @default.
• W2158431570 sameAs 2158431570 @default.
• W2158431570 citedByCount "30" @default.
• W2158431570 countsByYear W21584315702012 @default.
• W2158431570 countsByYear W21584315702014 @default.
• W2158431570 countsByYear W21584315702017 @default.
• W2158431570 countsByYear W21584315702019 @default.
• W2158431570 countsByYear W21584315702021 @default.
• W2158431570 countsByYear W21584315702022 @default.
• W2158431570 crossrefType "journal-article" @default.
• W2158431570 hasAuthorship W2158431570A5030021861 @default.
• W2158431570 hasAuthorship W2158431570A5047455011 @default.
• W2158431570 hasAuthorship W2158431570A5064491810 @default.
• W2158431570 hasAuthorship W2158431570A5066760659 @default.
• W2158431570 hasAuthorship W2158431570A5087602962 @default.
• W2158431570 hasBestOaLocation W21584315701 @default.
• W2158431570 hasConcept C126322002 @default.
• W2158431570 hasConcept C142724271 @default.
• W2158431570 hasConcept C19317047 @default.
• W2158431570 hasConcept C203014093 @default.
• W2158431570 hasConcept C2776090121 @default.
• W2158431570 hasConcept C2776820930 @default.

• next