Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158439879> ?p ?o ?g. }
- W2158439879 endingPage "1036" @default.
- W2158439879 startingPage "1028" @default.
- W2158439879 abstract "Increased glomerular hydraulic pressure has been suggested as a major causative factor in the development of glomerular sclerosis. The elevation of glomerular pressure increases the magnitude of stretch to mesangial cells. The study was, therefore, designed to investigate the effect of mechanical stretch on expression of TGF-beta and extracellular matrix components in cultured rat mesangial cells. The results showed that mechanical stretch stimulated mRNA expression for TGF-beta1 and TGF-beta3 in a time dependent manner, and that mesangial cells secreted substantial amounts of TGF-beta proteins in response to stretch. Stretch was also shown to stimulate mRNA expression for collagen types I and IV, and fibronectin, major components of mesangial extracellular matrix. The stretch-induced mRNA expression for extracellular matrix components was inhibited by neutralizing antibody to TGF-beta. Moreover, stretch-induced mRNA expression of TGF-beta was inhibited by tyrosine kinase inhibitors, genistein or herbimycin A, whereas Ca channel blockers nitrendipine or Gd3+, and inhibitors for protein kinase A or C had no effect. These findings indicate that stretch induced TGF-beta mRNA primarily through tyrosine kinase-dependent mechanisms in cultured rat mesangial cells, and the secreted TGF-beta may play a significant role for the stretch-induced expression of extracellular matrix proteins. Our results suggest that stretch-induced TGF-beta of mesangial cells might be a mediator in the progression of glomerular sclerosis as an autocrine/paracrine factor." @default.
- W2158439879 created "2016-06-24" @default.
- W2158439879 creator A5003059700 @default.
- W2158439879 creator A5015086199 @default.
- W2158439879 creator A5019990331 @default.
- W2158439879 creator A5022455452 @default.
- W2158439879 creator A5035758142 @default.
- W2158439879 creator A5048462960 @default.
- W2158439879 creator A5058121331 @default.
- W2158439879 creator A5061268398 @default.
- W2158439879 creator A5071830147 @default.
- W2158439879 creator A5074432933 @default.
- W2158439879 creator A5080266991 @default.
- W2158439879 date "1997-04-01" @default.
- W2158439879 modified "2023-10-12" @default.
- W2158439879 title "Tyrosine kinase dependent expression of TGF-β induced by stretch in mesangial cells" @default.
- W2158439879 cites W121429037 @default.
- W2158439879 cites W1479831323 @default.
- W2158439879 cites W1494055834 @default.
- W2158439879 cites W1505978562 @default.
- W2158439879 cites W1517558040 @default.
- W2158439879 cites W1522083389 @default.
- W2158439879 cites W1524114372 @default.
- W2158439879 cites W1591556642 @default.
- W2158439879 cites W1705232837 @default.
- W2158439879 cites W1971878230 @default.
- W2158439879 cites W1972855586 @default.
- W2158439879 cites W1981562838 @default.
- W2158439879 cites W1984261234 @default.
- W2158439879 cites W1984963586 @default.
- W2158439879 cites W1993851092 @default.
- W2158439879 cites W1994937757 @default.
- W2158439879 cites W1995700570 @default.
- W2158439879 cites W2031131334 @default.
- W2158439879 cites W2050206288 @default.
- W2158439879 cites W2063928700 @default.
- W2158439879 cites W2080224680 @default.
- W2158439879 cites W2090668636 @default.
- W2158439879 cites W2091031177 @default.
- W2158439879 cites W2098302088 @default.
- W2158439879 cites W2136819827 @default.
- W2158439879 cites W2145356697 @default.
- W2158439879 cites W2153549628 @default.
- W2158439879 cites W2161454032 @default.
- W2158439879 cites W2168234252 @default.
- W2158439879 cites W4294216491 @default.
- W2158439879 doi "https://doi.org/10.1038/ki.1997.144" @default.
- W2158439879 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9083267" @default.
- W2158439879 hasPublicationYear "1997" @default.
- W2158439879 type Work @default.
- W2158439879 sameAs 2158439879 @default.
- W2158439879 citedByCount "94" @default.
- W2158439879 countsByYear W21584398792012 @default.
- W2158439879 countsByYear W21584398792013 @default.
- W2158439879 countsByYear W21584398792015 @default.
- W2158439879 countsByYear W21584398792019 @default.
- W2158439879 countsByYear W21584398792022 @default.
- W2158439879 countsByYear W21584398792023 @default.
- W2158439879 crossrefType "journal-article" @default.
- W2158439879 hasAuthorship W2158439879A5003059700 @default.
- W2158439879 hasAuthorship W2158439879A5015086199 @default.
- W2158439879 hasAuthorship W2158439879A5019990331 @default.
- W2158439879 hasAuthorship W2158439879A5022455452 @default.
- W2158439879 hasAuthorship W2158439879A5035758142 @default.
- W2158439879 hasAuthorship W2158439879A5048462960 @default.
- W2158439879 hasAuthorship W2158439879A5058121331 @default.
- W2158439879 hasAuthorship W2158439879A5061268398 @default.
- W2158439879 hasAuthorship W2158439879A5071830147 @default.
- W2158439879 hasAuthorship W2158439879A5074432933 @default.
- W2158439879 hasAuthorship W2158439879A5080266991 @default.
- W2158439879 hasBestOaLocation W21584398791 @default.
- W2158439879 hasConcept C118131993 @default.
- W2158439879 hasConcept C126322002 @default.
- W2158439879 hasConcept C128240485 @default.
- W2158439879 hasConcept C134018914 @default.
- W2158439879 hasConcept C170493617 @default.
- W2158439879 hasConcept C185592680 @default.
- W2158439879 hasConcept C189165786 @default.
- W2158439879 hasConcept C2778229498 @default.
- W2158439879 hasConcept C2779131090 @default.
- W2158439879 hasConcept C2780091579 @default.
- W2158439879 hasConcept C2781381406 @default.
- W2158439879 hasConcept C42362537 @default.
- W2158439879 hasConcept C62478195 @default.
- W2158439879 hasConcept C71924100 @default.
- W2158439879 hasConcept C7876069 @default.
- W2158439879 hasConcept C86492073 @default.
- W2158439879 hasConcept C86803240 @default.
- W2158439879 hasConcept C95444343 @default.
- W2158439879 hasConceptScore W2158439879C118131993 @default.
- W2158439879 hasConceptScore W2158439879C126322002 @default.
- W2158439879 hasConceptScore W2158439879C128240485 @default.
- W2158439879 hasConceptScore W2158439879C134018914 @default.
- W2158439879 hasConceptScore W2158439879C170493617 @default.
- W2158439879 hasConceptScore W2158439879C185592680 @default.
- W2158439879 hasConceptScore W2158439879C189165786 @default.
- W2158439879 hasConceptScore W2158439879C2778229498 @default.
- W2158439879 hasConceptScore W2158439879C2779131090 @default.