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• W2158440149 endingPage "452" @default.
• W2158440149 startingPage "439" @default.
• W2158440149 abstract "Recent studies have identified brain correlates of placebo analgesia, but none have assessed how accurately patterns of brain activity can predict individual differences in placebo responses. We reanalyzed data from two fMRI studies of placebo analgesia (N = 47), using patterns of fMRI activity during the anticipation and experience of pain to predict new subjects' scores on placebo analgesia and placebo-induced changes in pain processing. We used a cross-validated regression procedure, LASSO-PCR, which provided both unbiased estimates of predictive accuracy and interpretable maps of which regions are most important for prediction. Increased anticipatory activity in a frontoparietal network and decreases in a posterior insular/temporal network predicted placebo analgesia. Patterns of anticipatory activity across the cortex predicted a moderate amount of variance in the placebo response (∼12% overall, ∼40% for study 2 alone), which is substantial considering the multiple likely contributing factors. The most predictive regions were those associated with emotional appraisal, rather than cognitive control or pain processing. During pain, decreases in limbic and paralimbic regions most strongly predicted placebo analgesia. Responses within canonical pain-processing regions explained significant variance in placebo analgesia, but the pattern of effects was inconsistent with widespread decreases in nociceptive processing. Together, the findings suggest that engagement of emotional appraisal circuits drives individual variation in placebo analgesia, rather than early suppression of nociceptive processing. This approach provides a framework that will allow prediction accuracy to increase as new studies provide more precise information for future predictive models." @default.
• W2158440149 created "2016-06-24" @default.
• W2158440149 creator A5006154621 @default.
• W2158440149 creator A5015217128 @default.
• W2158440149 creator A5041962211 @default.
• W2158440149 creator A5058586273 @default.
• W2158440149 date "2011-01-12" @default.
• W2158440149 modified "2023-10-16" @default.
• W2158440149 title "Predicting Individual Differences in Placebo Analgesia: Contributions of Brain Activity during Anticipation and Pain Experience" @default.
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• W2158440149 doi "https://doi.org/10.1523/jneurosci.3420-10.2011" @default.
• W2158440149 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3735131" @default.

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