FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158444316> ?p ?o ?g. }

• W2158444316 endingPage "103" @default.
• W2158444316 startingPage "99" @default.
• W2158444316 abstract "Object. Implantation of controlled-release polymers into the subarachnoid space to deliver drugs for treatment of vasospasm after subarachnoid hemorrhage (SAH) is currently of interest. Among the issues regarding local delivery of drugs in the subarachnoid space, however, are the extent of diffusion and the rate of release of the loaded agents. In this study Evans blue dye (EBD) was loaded into controlled-release polymers and its pharmacokinetic properties were determined in vitro and in vivo by using a rabbit model of SAH. Methods. Ethylene—vinyl acetate copolymer (EVAc) was loaded 40% (w:w) with EBD and its pharmacokinetics were spectrophotometrically determined in vitro by examining three EBD—EVAc polymers. Additional polymers were implanted either into the frontal lobe or into the cisterna magna of 16 New Zealand White rabbits. Subarachnoid hemorrhage was induced in eight of the animals by an injection of 1.5 ml of arterial blood into the cisterna magna. The animals were killed 3 or 14 days postoperatively, their brains and spinal cords were harvested, and samples of each were placed in formamide for dye extraction and quantification. Specimens were examined macroscopically and the concentrations of EBD were determined with the aid of a spectrophotometer. The EBD—EVAc polymers continuously released EBD over a 133-day period. The controlled release of the dye into the subarachnoid space in either location resulted in staining of the entire central nervous system (CNS) in rabbits when the polymers were placed either on the frontal lobe or in the cisterna magna. The EBD diffusion covered a distance of at least 40 cm. The presence of blood in the subarachnoid space did not interfere with the diffusion. Conclusions. In this study the authors define the rate and extent of diffusion of EBD from controlled-release polymers placed in the subarachnoid space under conditions of SAH. Evans blue dye diffused through the entire rabbit CNS, covering a distance greater than that of the longest dimension of the hemicircumference of the subarachnoid space around the human brain. The pharmacokinetic properties of EBD—EVAc polymers are comparable to those of antivasospasm agents that are successfully used in animal models of SAH." @default.
• W2158444316 created "2016-06-24" @default.
• W2158444316 creator A5011121905 @default.
• W2158444316 creator A5013988180 @default.
• W2158444316 creator A5040305872 @default.
• W2158444316 creator A5042224273 @default.
• W2158444316 creator A5058585977 @default.
• W2158444316 date "2004-07-01" @default.
• W2158444316 modified "2023-10-15" @default.
• W2158444316 title "Pharmacokinetics of controlled-release polymers in the subarachnoid space after subarachnoid hemorrhage in rabbits" @default.
• W2158444316 cites W113533163 @default.
• W2158444316 cites W1591445392 @default.
• W2158444316 cites W1659229200 @default.
• W2158444316 cites W1964863479 @default.
• W2158444316 cites W1967016288 @default.
• W2158444316 cites W1978887478 @default.
• W2158444316 cites W1990695136 @default.
• W2158444316 cites W1997834073 @default.
• W2158444316 cites W2000303682 @default.
• W2158444316 cites W2004467890 @default.
• W2158444316 cites W2050939682 @default.
• W2158444316 cites W2054621963 @default.
• W2158444316 cites W2060456045 @default.
• W2158444316 cites W2073256642 @default.
• W2158444316 cites W2074186952 @default.
• W2158444316 cites W2089686933 @default.
• W2158444316 cites W2094505927 @default.
• W2158444316 cites W2135786724 @default.
• W2158444316 cites W2146228631 @default.
• W2158444316 cites W2166777336 @default.
• W2158444316 cites W2179882653 @default.
• W2158444316 cites W80245789 @default.
• W2158444316 doi "https://doi.org/10.3171/jns.2004.101.1.0099" @default.
• W2158444316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15255258" @default.
• W2158444316 hasPublicationYear "2004" @default.
• W2158444316 type Work @default.
• W2158444316 sameAs 2158444316 @default.
• W2158444316 citedByCount "13" @default.
• W2158444316 countsByYear W21584443162019 @default.
• W2158444316 crossrefType "journal-article" @default.
• W2158444316 hasAuthorship W2158444316A5011121905 @default.
• W2158444316 hasAuthorship W2158444316A5013988180 @default.
• W2158444316 hasAuthorship W2158444316A5040305872 @default.
• W2158444316 hasAuthorship W2158444316A5042224273 @default.
• W2158444316 hasAuthorship W2158444316A5058585977 @default.
• W2158444316 hasBestOaLocation W21584443161 @default.
• W2158444316 hasConcept C112705442 @default.
• W2158444316 hasConcept C126322002 @default.
• W2158444316 hasConcept C142724271 @default.
• W2158444316 hasConcept C150903083 @default.
• W2158444316 hasConcept C207001950 @default.
• W2158444316 hasConcept C2777649898 @default.
• W2158444316 hasConcept C2777736543 @default.
• W2158444316 hasConcept C2778200158 @default.
• W2158444316 hasConcept C2778506911 @default.
• W2158444316 hasConcept C2779651940 @default.
• W2158444316 hasConcept C2780813603 @default.
• W2158444316 hasConcept C42219234 @default.
• W2158444316 hasConcept C71924100 @default.
• W2158444316 hasConcept C86803240 @default.
• W2158444316 hasConcept C98274493 @default.
• W2158444316 hasConceptScore W2158444316C112705442 @default.
• W2158444316 hasConceptScore W2158444316C126322002 @default.
• W2158444316 hasConceptScore W2158444316C142724271 @default.
• W2158444316 hasConceptScore W2158444316C150903083 @default.
• W2158444316 hasConceptScore W2158444316C207001950 @default.
• W2158444316 hasConceptScore W2158444316C2777649898 @default.
• W2158444316 hasConceptScore W2158444316C2777736543 @default.
• W2158444316 hasConceptScore W2158444316C2778200158 @default.
• W2158444316 hasConceptScore W2158444316C2778506911 @default.
• W2158444316 hasConceptScore W2158444316C2779651940 @default.
• W2158444316 hasConceptScore W2158444316C2780813603 @default.
• W2158444316 hasConceptScore W2158444316C42219234 @default.
• W2158444316 hasConceptScore W2158444316C71924100 @default.
• W2158444316 hasConceptScore W2158444316C86803240 @default.
• W2158444316 hasConceptScore W2158444316C98274493 @default.
• W2158444316 hasIssue "1" @default.
• W2158444316 hasLocation W21584443161 @default.
• W2158444316 hasLocation W21584443162 @default.
• W2158444316 hasOpenAccess W2158444316 @default.
• W2158444316 hasPrimaryLocation W21584443161 @default.
• W2158444316 hasRelatedWork W1979052642 @default.
• W2158444316 hasRelatedWork W2023597875 @default.
• W2158444316 hasRelatedWork W2027790247 @default.
• W2158444316 hasRelatedWork W2049656119 @default.
• W2158444316 hasRelatedWork W2050478537 @default.
• W2158444316 hasRelatedWork W3028786997 @default.
• W2158444316 hasRelatedWork W3140407408 @default.
• W2158444316 hasRelatedWork W3146752380 @default.
• W2158444316 hasRelatedWork W4210962255 @default.
• W2158444316 hasRelatedWork W3029547126 @default.
• W2158444316 hasVolume "101" @default.
• W2158444316 isParatext "false" @default.
• W2158444316 isRetracted "false" @default.
• W2158444316 magId "2158444316" @default.
• W2158444316 workType "article" @default.