Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158448522> ?p ?o ?g. }
- W2158448522 abstract "In neonatal rat anterior and neurointermediate pituitary lobe explant cultures maintained in complete serum-free medium for up to 3 weeks, the ACTH/endorphin-related peptide content rose about 3-fold. The basal secretion rates of the ACTH/endorphin-related peptides were 0.2-0.3% and 0.6-0.7% of the cell content secreted/h in the anterior and neurointermediate pituitary lobe explants, respectively. Acute treatment of anterior pituitary explants with 10 nM CRF or 0.5 mM (Bu)2-cAMP-0.5 mM isobutylmethylxanthine resulted in about 6- and 9-fold increases in the basal secretion rates, respectively. Pretreatment of the anterior pituitary cultures with 100 nM dexamethasone for 3 days did not alter the basal secretion rate, but drastically reduced both CRF- and cAMP-stimulated release of peptides. In the anterior pituitary explants, chronic CRF treatment resulted in a dose-dependent increase in secreted ACTH/endorphin-related peptides measured in the medium, and this elevation in secretion rate was maintained throughout 12 days of chronic exposure to CRF. Total hormone produced by neonatal anterior pituitary explant cultures was increased 2- to 4-fold by chronic CRF treatment (10 and 100 nM CRF) after 12 days in culture. Compared to the anterior pituitary lobe explants, the neurointermediate pituitary lobe explants were not very responsive to acute or chronic CRF treatment; exposure to 100 nM CRF resulted in about a 2-fold stimulation of the basal secretion rate. Acute exposure of the neurointermediate pituitary lobe explants to 1 microM isoproterenol or cAMP resulted in about 2- and 7-fold increases in the basal secretion rate, respectively. Dexamethasone pretreatment had little effect on either the basal or stimulated release of the ACTH/endorphin-related peptides. These studies demonstrated that some of the tissue-specific regulatory mechanisms involved in ACTH/endorphin-related peptide synthesis and secretion were present in developing explant cultures of anterior and neurointermediate pituitary lobes." @default.
- W2158448522 created "2016-06-24" @default.
- W2158448522 creator A5011997610 @default.
- W2158448522 creator A5071207193 @default.
- W2158448522 date "1986-08-01" @default.
- W2158448522 modified "2023-09-25" @default.
- W2158448522 title "Regulation of Adrenocorticotropin/Endorphin-Related Peptide Secretion in Neonatal Rat Pituitary Cultures*" @default.
- W2158448522 cites W1539006225 @default.
- W2158448522 cites W1552666003 @default.
- W2158448522 cites W1554188317 @default.
- W2158448522 cites W1571444008 @default.
- W2158448522 cites W171555081 @default.
- W2158448522 cites W1920955357 @default.
- W2158448522 cites W1927550448 @default.
- W2158448522 cites W1963539552 @default.
- W2158448522 cites W1969265171 @default.
- W2158448522 cites W1974791295 @default.
- W2158448522 cites W1983698852 @default.
- W2158448522 cites W1984265716 @default.
- W2158448522 cites W1987532556 @default.
- W2158448522 cites W1993984263 @default.
- W2158448522 cites W1994718440 @default.
- W2158448522 cites W1994873586 @default.
- W2158448522 cites W1999455548 @default.
- W2158448522 cites W2000372395 @default.
- W2158448522 cites W2014003861 @default.
- W2158448522 cites W2015066821 @default.
- W2158448522 cites W2017312144 @default.
- W2158448522 cites W2019577043 @default.
- W2158448522 cites W2028114973 @default.
- W2158448522 cites W2028502151 @default.
- W2158448522 cites W2030682383 @default.
- W2158448522 cites W2034584065 @default.
- W2158448522 cites W2047295469 @default.
- W2158448522 cites W2050622908 @default.
- W2158448522 cites W2059319460 @default.
- W2158448522 cites W2061954037 @default.
- W2158448522 cites W2063948679 @default.
- W2158448522 cites W2064676661 @default.
- W2158448522 cites W2068850166 @default.
- W2158448522 cites W2069576043 @default.
- W2158448522 cites W2070450824 @default.
- W2158448522 cites W2086574534 @default.
- W2158448522 cites W2087328208 @default.
- W2158448522 cites W2088357731 @default.
- W2158448522 cites W2112840121 @default.
- W2158448522 cites W2139806461 @default.
- W2158448522 cites W2154696034 @default.
- W2158448522 cites W2329372896 @default.
- W2158448522 cites W2406838448 @default.
- W2158448522 cites W2081264545 @default.
- W2158448522 cites W2156499933 @default.
- W2158448522 doi "https://doi.org/10.1210/endo-119-2-793" @default.
- W2158448522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2426088" @default.
- W2158448522 hasPublicationYear "1986" @default.
- W2158448522 type Work @default.
- W2158448522 sameAs 2158448522 @default.
- W2158448522 citedByCount "17" @default.
- W2158448522 countsByYear W21584485222021 @default.
- W2158448522 crossrefType "journal-article" @default.
- W2158448522 hasAuthorship W2158448522A5011997610 @default.
- W2158448522 hasAuthorship W2158448522A5071207193 @default.
- W2158448522 hasConcept C126322002 @default.
- W2158448522 hasConcept C134018914 @default.
- W2158448522 hasConcept C157890192 @default.
- W2158448522 hasConcept C202751555 @default.
- W2158448522 hasConcept C2777658017 @default.
- W2158448522 hasConcept C2778024521 @default.
- W2158448522 hasConcept C2779029589 @default.
- W2158448522 hasConcept C2779306644 @default.
- W2158448522 hasConcept C2780546910 @default.
- W2158448522 hasConcept C49039625 @default.
- W2158448522 hasConcept C55493867 @default.
- W2158448522 hasConcept C71315377 @default.
- W2158448522 hasConcept C71924100 @default.
- W2158448522 hasConcept C86803240 @default.
- W2158448522 hasConceptScore W2158448522C126322002 @default.
- W2158448522 hasConceptScore W2158448522C134018914 @default.
- W2158448522 hasConceptScore W2158448522C157890192 @default.
- W2158448522 hasConceptScore W2158448522C202751555 @default.
- W2158448522 hasConceptScore W2158448522C2777658017 @default.
- W2158448522 hasConceptScore W2158448522C2778024521 @default.
- W2158448522 hasConceptScore W2158448522C2779029589 @default.
- W2158448522 hasConceptScore W2158448522C2779306644 @default.
- W2158448522 hasConceptScore W2158448522C2780546910 @default.
- W2158448522 hasConceptScore W2158448522C49039625 @default.
- W2158448522 hasConceptScore W2158448522C55493867 @default.
- W2158448522 hasConceptScore W2158448522C71315377 @default.
- W2158448522 hasConceptScore W2158448522C71924100 @default.
- W2158448522 hasConceptScore W2158448522C86803240 @default.
- W2158448522 hasLocation W21584485221 @default.
- W2158448522 hasLocation W21584485222 @default.
- W2158448522 hasOpenAccess W2158448522 @default.
- W2158448522 hasPrimaryLocation W21584485221 @default.
- W2158448522 hasRelatedWork W1966296538 @default.
- W2158448522 hasRelatedWork W1972504921 @default.
- W2158448522 hasRelatedWork W1974514730 @default.
- W2158448522 hasRelatedWork W2020367384 @default.
- W2158448522 hasRelatedWork W2021595401 @default.
- W2158448522 hasRelatedWork W2067973425 @default.