Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158473668> ?p ?o ?g. }
- W2158473668 endingPage "252" @default.
- W2158473668 startingPage "243" @default.
- W2158473668 abstract "Background: We wished to examine the impact of a short course of oral corticosteroids on the immune function of children with acute asthma and explore the mechanism of immune suppression, if any. Methods: We conducted a prospective cohort study of children aged 3–17 years presenting with acute asthma to the emergency department. The exposure of interest was a short course of systemic corticosteroids. In emergency department, corticosteroid-treated and nonexposed children were immunized with 3 antigens, namely, a neoantigen (Bacteriophage φX 174) and 2 recall antigens (diphtheria and tetanus). After 5 ± 1 weeks, children were reimmunized with Bacteriophage φX 174. Antibody titers were measured 1, 2 (peak), and 5 weeks after the primary immunization, and 1 week (peak) after the secondary one. Results: We enrolled 41 children, 27 treated with and 14 unexposed to oral corticosteroids. Corticosteroid-treated children displayed an 85% lower adjusted total (IgG and IgM) peak titers to the primary Bacteriophage immunization compared to controls [ratio of geometric means (95% confidence interval): 15% (5% to 43%)]. There were no group differences in the rise of diphtheria or tetanus antibodies. After the secondary Bacteriophage immunization, corticosteroid-treated patients showed no significant group difference in peak total titers [ratio of geometric means (95% confidence interval): 1.84% (0.66%, 5.10%)], amplification and absolute, and percent IgG titers as compared to unexposed children. Conclusions: In children with acute asthma, a short course of oral corticosteroids may be associated with depressed immune response to a new antigen, with recovery within 6 weeks and no apparent impact on response to known antigens." @default.
- W2158473668 created "2016-06-24" @default.
- W2158473668 creator A5026378846 @default.
- W2158473668 creator A5046143675 @default.
- W2158473668 creator A5062237763 @default.
- W2158473668 creator A5065533338 @default.
- W2158473668 creator A5080844454 @default.
- W2158473668 date "2010-12-01" @default.
- W2158473668 modified "2023-10-01" @default.
- W2158473668 title "A Short Burst of Oral Corticosteroid for Children with Acute Asthma: Is There an Impact on Immunity?" @default.
- W2158473668 cites W1502573475 @default.
- W2158473668 cites W1591786310 @default.
- W2158473668 cites W160917378 @default.
- W2158473668 cites W1963948224 @default.
- W2158473668 cites W1968241220 @default.
- W2158473668 cites W1969280028 @default.
- W2158473668 cites W1994474065 @default.
- W2158473668 cites W1998895943 @default.
- W2158473668 cites W2006334336 @default.
- W2158473668 cites W2009067897 @default.
- W2158473668 cites W2009439458 @default.
- W2158473668 cites W2012923862 @default.
- W2158473668 cites W2015763539 @default.
- W2158473668 cites W2018701700 @default.
- W2158473668 cites W2024856029 @default.
- W2158473668 cites W2033638211 @default.
- W2158473668 cites W2039134173 @default.
- W2158473668 cites W2046992184 @default.
- W2158473668 cites W2053612940 @default.
- W2158473668 cites W2069827333 @default.
- W2158473668 cites W2071343391 @default.
- W2158473668 cites W2075067573 @default.
- W2158473668 cites W2075763185 @default.
- W2158473668 cites W2076489452 @default.
- W2158473668 cites W2077157239 @default.
- W2158473668 cites W2080151057 @default.
- W2158473668 cites W2081570389 @default.
- W2158473668 cites W2088274041 @default.
- W2158473668 cites W2090241666 @default.
- W2158473668 cites W2101995737 @default.
- W2158473668 cites W2119425733 @default.
- W2158473668 cites W2121690051 @default.
- W2158473668 cites W2130793570 @default.
- W2158473668 cites W2132557753 @default.
- W2158473668 cites W2132890998 @default.
- W2158473668 cites W4205896725 @default.
- W2158473668 cites W4256315250 @default.
- W2158473668 doi "https://doi.org/10.1089/ped.2010.0041" @default.
- W2158473668 hasPublicationYear "2010" @default.
- W2158473668 type Work @default.
- W2158473668 sameAs 2158473668 @default.
- W2158473668 citedByCount "6" @default.
- W2158473668 countsByYear W21584736682012 @default.
- W2158473668 countsByYear W21584736682016 @default.
- W2158473668 countsByYear W21584736682022 @default.
- W2158473668 crossrefType "journal-article" @default.
- W2158473668 hasAuthorship W2158473668A5026378846 @default.
- W2158473668 hasAuthorship W2158473668A5046143675 @default.
- W2158473668 hasAuthorship W2158473668A5062237763 @default.
- W2158473668 hasAuthorship W2158473668A5065533338 @default.
- W2158473668 hasAuthorship W2158473668A5080844454 @default.
- W2158473668 hasConcept C118552586 @default.
- W2158473668 hasConcept C126322002 @default.
- W2158473668 hasConcept C147483822 @default.
- W2158473668 hasConcept C159654299 @default.
- W2158473668 hasConcept C187212893 @default.
- W2158473668 hasConcept C188816634 @default.
- W2158473668 hasConcept C203014093 @default.
- W2158473668 hasConcept C22070199 @default.
- W2158473668 hasConcept C22889606 @default.
- W2158473668 hasConcept C2776042228 @default.
- W2158473668 hasConcept C2776804153 @default.
- W2158473668 hasConcept C2779841045 @default.
- W2158473668 hasConcept C2780572238 @default.
- W2158473668 hasConcept C2780724011 @default.
- W2158473668 hasConcept C2780801004 @default.
- W2158473668 hasConcept C32611913 @default.
- W2158473668 hasConcept C44249647 @default.
- W2158473668 hasConcept C71924100 @default.
- W2158473668 hasConceptScore W2158473668C118552586 @default.
- W2158473668 hasConceptScore W2158473668C126322002 @default.
- W2158473668 hasConceptScore W2158473668C147483822 @default.
- W2158473668 hasConceptScore W2158473668C159654299 @default.
- W2158473668 hasConceptScore W2158473668C187212893 @default.
- W2158473668 hasConceptScore W2158473668C188816634 @default.
- W2158473668 hasConceptScore W2158473668C203014093 @default.
- W2158473668 hasConceptScore W2158473668C22070199 @default.
- W2158473668 hasConceptScore W2158473668C22889606 @default.
- W2158473668 hasConceptScore W2158473668C2776042228 @default.
- W2158473668 hasConceptScore W2158473668C2776804153 @default.
- W2158473668 hasConceptScore W2158473668C2779841045 @default.
- W2158473668 hasConceptScore W2158473668C2780572238 @default.
- W2158473668 hasConceptScore W2158473668C2780724011 @default.
- W2158473668 hasConceptScore W2158473668C2780801004 @default.
- W2158473668 hasConceptScore W2158473668C32611913 @default.
- W2158473668 hasConceptScore W2158473668C44249647 @default.
- W2158473668 hasConceptScore W2158473668C71924100 @default.
- W2158473668 hasIssue "4" @default.