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- W2158477498 abstract "Purpose: Adjuvant radiation therapy could reduce loco regional failure,but currently has no defined role because of previously reported morbidity.NCI-Cairo routine work is to give adjuvant PORT for locally advanced bladdercarcinoma patients. The aim of this work is to re-evaluate this protocolregarding its effect on prognosis and complications. Patients and Method: Aretrospective study included 208 patients with pathologically proven bladdercancer who presented to the NCI, Cairo University from 2007-2011. All of themunderwent RC with bilateral PLND followed by conventional post-operativeradiotherapy in 2 - 6 weeks after surgery for 5000 cGy in 25 fractions, over 5weeks using 2D technique. Analysis of data from their files was done for thetreatment results, prognostic factors and complications. Results: Three yearsoverall survival (OS) and disease free survival (DFS) for the whole group was ~60%,and 54% respectively in favour of the female gender, non-smokers, Squamous cellcarcinoma patients, low grade tumours (grade 1 and 2) negative margins, N0,pT2b and early stage group showed the best prognoses. The 3 years metastasesfree survival (MFS) was ~71%. Only four factors showed a significant relationwith the MFS which were the grade, LN status, T-stage and group staging. Thelocal recurrence rate (LRC) at 2 years for the whole group was ~95% and 94% at3 years. Only surgical margin status and extent of LN dissection had asignificant impact on the LRC. Conclusions: Adjuvant radiotherapy showssustained improvement in the loco regional control, and should be recommendedfor patients with locally advanced disease especially those with less than 10dissected lymph nodes and those with positive margins." @default.
- W2158477498 created "2016-06-24" @default.
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- W2158477498 date "2015-01-01" @default.
- W2158477498 modified "2023-10-01" @default.
- W2158477498 title "Postoperative Radiotherapy in Bladder Cancer Patients: 5-Year Institutional Experience of National Cancer Institute, Cairo University" @default.
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- W2158477498 doi "https://doi.org/10.4236/jct.2015.67063" @default.
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