Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158485728> ?p ?o ?g. }
- W2158485728 abstract "The only available treatment for embolic stroke is recombinant tissue plasminogen activator, which must be administered within three hours of stroke onset. We examined the effects of 1,3-di-o-tolyguanidine (DTG), a high affinity sigma receptor agonist, as a potential treatment for decreasing infarct area at delayed time points. Rats were subjected to permanent embolic middle cerebral artery occlusion (MCAO) and allowed to recover before receiving subcutaneous injections of 15 mg/kg of DTG at 24, 48, and 72 hours. At 96 hours the rats were euthanized, and brains harvested and sectioned. Infarct areas were quantified at the level of the cortical/striatal and cortical/hippocampal regions in control (MCAO-only) and DTG treated animals using the marker for neurodegeneration, Fluoro–Jade. DTG treatment significantly reduced infarct area in both cortical/striatal and cortical/hippocampal regions by >80%, relative to control rats. These findings were confirmed by immunohistochemical experiments using a neuronal marker, mouse anti-neuronal nuclei monoclonal antibody (NeuN), which showed that application of DTG significantly increased the number of viable neurons in these regions. Furthermore, DTG blocked the inflammatory response evoked by MCAO, as indicated by decreases in the number of reactive astrocytes and activated microglia/macrophages detected by immunostaining for glial fibrillary acidic protein (GFAP) and binding of isolectin IB4, respectively. Thus, our results demonstrate that the sigma receptor-selective agonist, DTG, can enhance neuronal survival when administered 24 hr after an ischemic stroke. In addition, the efficacy of sigma receptors for stroke treatment at delayed time" @default.
- W2158485728 created "2016-06-24" @default.
- W2158485728 creator A5028962298 @default.
- W2158485728 date "2007-01-01" @default.
- W2158485728 modified "2023-09-27" @default.
- W2158485728 title "Alternative targets for the treatment of stroke" @default.
- W2158485728 cites W1171331324 @default.
- W2158485728 cites W136692196 @default.
- W2158485728 cites W1498166809 @default.
- W2158485728 cites W1513532732 @default.
- W2158485728 cites W1515994079 @default.
- W2158485728 cites W1533229430 @default.
- W2158485728 cites W1544915536 @default.
- W2158485728 cites W1560983797 @default.
- W2158485728 cites W1573797238 @default.
- W2158485728 cites W1594425991 @default.
- W2158485728 cites W1659985814 @default.
- W2158485728 cites W1668344921 @default.
- W2158485728 cites W1672565987 @default.
- W2158485728 cites W1821918060 @default.
- W2158485728 cites W1886668162 @default.
- W2158485728 cites W1900414416 @default.
- W2158485728 cites W1919518154 @default.
- W2158485728 cites W1952514571 @default.
- W2158485728 cites W1964187920 @default.
- W2158485728 cites W1965617341 @default.
- W2158485728 cites W1965991802 @default.
- W2158485728 cites W1965995070 @default.
- W2158485728 cites W1966545752 @default.
- W2158485728 cites W1967235746 @default.
- W2158485728 cites W1967315269 @default.
- W2158485728 cites W1967659379 @default.
- W2158485728 cites W1968130780 @default.
- W2158485728 cites W1968576491 @default.
- W2158485728 cites W1968589480 @default.
- W2158485728 cites W1969768548 @default.
- W2158485728 cites W1971153516 @default.
- W2158485728 cites W1971668430 @default.
- W2158485728 cites W1971792511 @default.
- W2158485728 cites W1972176624 @default.
- W2158485728 cites W1972312480 @default.
- W2158485728 cites W1972517114 @default.
- W2158485728 cites W1972534236 @default.
- W2158485728 cites W1973737797 @default.
- W2158485728 cites W1973742265 @default.
- W2158485728 cites W1974916613 @default.
- W2158485728 cites W1975611817 @default.
- W2158485728 cites W1979696767 @default.
- W2158485728 cites W1980181546 @default.
- W2158485728 cites W1980793025 @default.
- W2158485728 cites W1980832959 @default.
- W2158485728 cites W1981705617 @default.
- W2158485728 cites W1982702072 @default.
- W2158485728 cites W1983612328 @default.
- W2158485728 cites W1983823375 @default.
- W2158485728 cites W1987025125 @default.
- W2158485728 cites W1988985649 @default.
- W2158485728 cites W1990711213 @default.
- W2158485728 cites W1991619596 @default.
- W2158485728 cites W1992768650 @default.
- W2158485728 cites W1993381694 @default.
- W2158485728 cites W1994224293 @default.
- W2158485728 cites W1994600803 @default.
- W2158485728 cites W1997748971 @default.
- W2158485728 cites W1998814509 @default.
- W2158485728 cites W1999388090 @default.
- W2158485728 cites W1999842143 @default.
- W2158485728 cites W2000775111 @default.
- W2158485728 cites W2002332690 @default.
- W2158485728 cites W2003556082 @default.
- W2158485728 cites W2004351423 @default.
- W2158485728 cites W2004514472 @default.
- W2158485728 cites W2004626052 @default.
- W2158485728 cites W2006004617 @default.
- W2158485728 cites W2007187686 @default.
- W2158485728 cites W2007511428 @default.
- W2158485728 cites W2008180790 @default.
- W2158485728 cites W2008373701 @default.
- W2158485728 cites W2010711319 @default.
- W2158485728 cites W2010714560 @default.
- W2158485728 cites W2010980945 @default.
- W2158485728 cites W2011135701 @default.
- W2158485728 cites W2011766778 @default.
- W2158485728 cites W2013603704 @default.
- W2158485728 cites W2014768234 @default.
- W2158485728 cites W2015085032 @default.
- W2158485728 cites W2015914981 @default.
- W2158485728 cites W2017185590 @default.
- W2158485728 cites W2018084900 @default.
- W2158485728 cites W2020742466 @default.
- W2158485728 cites W2021311015 @default.
- W2158485728 cites W2023213942 @default.
- W2158485728 cites W2023933035 @default.
- W2158485728 cites W2025326202 @default.
- W2158485728 cites W2029392623 @default.
- W2158485728 cites W2030652025 @default.
- W2158485728 cites W2031082537 @default.
- W2158485728 cites W2031236369 @default.
- W2158485728 cites W2032841404 @default.
- W2158485728 cites W2032877768 @default.