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• W2158488893 abstract "Abstract The murine antibody response to T‐independent (TI)‐2 antigens [2,4‐dinitrophenyl‐Lys‐Ficoll (DNP‐FIC) and DNP‐hydroxyethyl starch (HES)] was impaired long after splenectomy, while responses to TI‐1 [trinitrophenylated lipopolysaccharide (TNP‐LPS)] and thymus‐dependent [TNP‐keyhole limpet hemocyanin (KLH)] antigens were largely unaffected. The antibody response to these TI‐2 antigens was exclusively against the conjugated epitopes [DNP‐, fluorescein isothiocyanate (FITC)‐ or tetramethylrhodamine isothiocyanate (TRITC)‐Ficoll or ‐HES]. Fluorescent conjugates of Ficoll and HES localize selectively to the splenic marginal zone macrophages. This localization was not affected by 750 cGy of X‐irradiation, but the antibody response to the TI‐2 antigens was abrogated for 14 days. Administration of spleen cells restored the antibody response to these TI‐2 antigens in otherwise intact irradiated mice but not if they had been splenectomized. Our findings indicate that the antibody response to TI‐2 antigens depends upon stimulation of B cells in a splenic environment. This probably involves antigen presentation by marginal zone macrophages." @default.
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• W2158488893 date "1985-01-01" @default.
• W2158488893 modified "2023-10-14" @default.
• W2158488893 title "Splenic dependence of the antibody response to thymus‐independent (TI‐2) antigens" @default.
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• W2158488893 doi "https://doi.org/10.1002/eji.1830150516" @default.
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