FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158494564> ?p ?o ?g. }

• W2158494564 endingPage "840" @default.
• W2158494564 startingPage "833" @default.
• W2158494564 abstract "We evaluated the mutation status of c-Met in small cell lung cancer (SCLC) and neuroendocrine tumors (NET), for which relatively limited therapeutic targets have been explored.c-Met was re-sequenced using cell lines and clinical samples. For in vitro studies, DNA constructs containing a juxtamembrane domain (JMD) and tyrosine kinase domain (TKD) were generated. Detected mutations were introduced into the construct and effects on c-Met phosphorylation and interaction with tyrosine kinase inhibitor drugs BMS777607 and SU11274 were assessed.97 specimens were analyzed: 13 SCLC and 2 pulmonary carcinoid cell lines, 46 SCLC and 36 NET clinical specimens. Mutations were only detected in the JMD. No mutations were detected in the TKD. Found mutations consisted of the previously reported R988C and T1010I mutations. One novel JMD mutation, P996S, was detected in a SCLC specimen. The mutation rate in SCLC cell lines was 25% (31% including a derivative cell line), and 6.5% in clinical specimens. The mutation rate in NET was 8.3%. In vitro, there were no differences between wild type, R988C or T1010I mutants regarding c-Met phosphorylation at Y1003, located in the JMD, and at Y1234/1235, located in the TKD. BMS777607 and SU11274 were shown to inhibit phosphorylation of c-Met in wild type and R988C and T1010I mutants in a similar fashion.In SCLC and neuroendocrine tumors MET mutations are relatively rare. Detected mutations were located in the juxtamembrane domain and were of no functional relevance as they did not influence c-Met phosphorylation, regardless of TKI treatment." @default.
• W2158494564 created "2016-06-24" @default.
• W2158494564 creator A5000883389 @default.
• W2158494564 creator A5002479582 @default.
• W2158494564 creator A5011258855 @default.
• W2158494564 creator A5016097820 @default.
• W2158494564 creator A5023012274 @default.
• W2158494564 creator A5033986673 @default.
• W2158494564 creator A5053247673 @default.
• W2158494564 creator A5056248348 @default.
• W2158494564 creator A5057301452 @default.
• W2158494564 creator A5057555103 @default.
• W2158494564 date "2013-02-01" @default.
• W2158494564 modified "2023-09-23" @default.
• W2158494564 title "Detection and Therapeutic Implications of c-Met Mutations in Small Cell Lung Cancer and Neuroendocrine Tumors" @default.
• W2158494564 cites W1535566085 @default.
• W2158494564 cites W1819318180 @default.
• W2158494564 cites W1971001418 @default.
• W2158494564 cites W1974203897 @default.
• W2158494564 cites W1981145667 @default.
• W2158494564 cites W1987379964 @default.
• W2158494564 cites W1996883110 @default.
• W2158494564 cites W1998322093 @default.
• W2158494564 cites W1998971866 @default.
• W2158494564 cites W2015217502 @default.
• W2158494564 cites W2019573100 @default.
• W2158494564 cites W2021452013 @default.
• W2158494564 cites W2029300043 @default.
• W2158494564 cites W2042323503 @default.
• W2158494564 cites W2048097275 @default.
• W2158494564 cites W2051093316 @default.
• W2158494564 cites W2051782283 @default.
• W2158494564 cites W2069421644 @default.
• W2158494564 cites W2073937000 @default.
• W2158494564 cites W2093613683 @default.
• W2158494564 cites W2094337993 @default.
• W2158494564 cites W2100370551 @default.
• W2158494564 cites W2114556798 @default.
• W2158494564 cites W2121262970 @default.
• W2158494564 cites W2131073955 @default.
• W2158494564 cites W2138404775 @default.
• W2158494564 cites W2138896702 @default.
• W2158494564 cites W2140270650 @default.
• W2158494564 cites W2155103465 @default.
• W2158494564 cites W2158424267 @default.
• W2158494564 cites W2164884227 @default.
• W2158494564 cites W2166066748 @default.
• W2158494564 cites W2171659230 @default.
• W2158494564 cites W2240997684 @default.
• W2158494564 cites W2274208933 @default.
• W2158494564 cites W62114904 @default.
• W2158494564 doi "https://doi.org/10.2174/138161213804547196" @default.
• W2158494564 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7569720" @default.
• W2158494564 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22973954" @default.
• W2158494564 hasPublicationYear "2013" @default.
• W2158494564 type Work @default.
• W2158494564 sameAs 2158494564 @default.
• W2158494564 citedByCount "25" @default.
• W2158494564 countsByYear W21584945642013 @default.
• W2158494564 countsByYear W21584945642014 @default.
• W2158494564 countsByYear W21584945642015 @default.
• W2158494564 countsByYear W21584945642016 @default.
• W2158494564 countsByYear W21584945642017 @default.
• W2158494564 countsByYear W21584945642019 @default.
• W2158494564 countsByYear W21584945642020 @default.
• W2158494564 countsByYear W21584945642022 @default.
• W2158494564 crossrefType "journal-article" @default.
• W2158494564 hasAuthorship W2158494564A5000883389 @default.
• W2158494564 hasAuthorship W2158494564A5002479582 @default.
• W2158494564 hasAuthorship W2158494564A5011258855 @default.
• W2158494564 hasAuthorship W2158494564A5016097820 @default.
• W2158494564 hasAuthorship W2158494564A5023012274 @default.
• W2158494564 hasAuthorship W2158494564A5033986673 @default.
• W2158494564 hasAuthorship W2158494564A5053247673 @default.
• W2158494564 hasAuthorship W2158494564A5056248348 @default.
• W2158494564 hasAuthorship W2158494564A5057301452 @default.
• W2158494564 hasAuthorship W2158494564A5057555103 @default.
• W2158494564 hasConcept C104317684 @default.
• W2158494564 hasConcept C11960822 @default.
• W2158494564 hasConcept C121608353 @default.
• W2158494564 hasConcept C134018914 @default.
• W2158494564 hasConcept C143065580 @default.
• W2158494564 hasConcept C153911025 @default.
• W2158494564 hasConcept C2779066768 @default.
• W2158494564 hasConcept C32619005 @default.
• W2158494564 hasConcept C501734568 @default.
• W2158494564 hasConcept C502942594 @default.
• W2158494564 hasConcept C54355233 @default.
• W2158494564 hasConcept C81885089 @default.
• W2158494564 hasConcept C86803240 @default.
• W2158494564 hasConceptScore W2158494564C104317684 @default.
• W2158494564 hasConceptScore W2158494564C11960822 @default.
• W2158494564 hasConceptScore W2158494564C121608353 @default.
• W2158494564 hasConceptScore W2158494564C134018914 @default.
• W2158494564 hasConceptScore W2158494564C143065580 @default.
• W2158494564 hasConceptScore W2158494564C153911025 @default.
• W2158494564 hasConceptScore W2158494564C2779066768 @default.
• W2158494564 hasConceptScore W2158494564C32619005 @default.

• next