FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158498082> ?p ?o ?g. }

• W2158498082 endingPage "292" @default.
• W2158498082 startingPage "282" @default.
• W2158498082 abstract "Elderly patients are more sensitive than younger patients to myocardial ischemia, which results in higher mortality. We investigated how aging affects the cardioprotective AMP-activated protein kinase (AMPK) signaling pathway.Ischemic AMPK activation was impaired in aged compared with young murine hearts. The expression and secretion of the AMPK upstream regulator, macrophage migration inhibitory factor (MIF), were lower in aged compared with young adult hearts. Additionally, the levels of hypoxia-inducible factor 1alpha, a known transcriptional activator of MIF, were reduced in aged compared with young hearts. Ischemia-induced AMPK activation in MIF knockout mice was blunted, leading to greater contractile dysfunction in MIF-deficient than in wild-type hearts. Furthermore, intramyocardial injection of adenovirus encoding MIF in aged mice increased MIF expression and ischemic AMPK activation and reduced infarct size.An impaired MIF-AMPK activation response in senescence thus may be attributed to an aging-associated defect in hypoxia-inducible factor 1alpha, the transcription factor for MIF. In the clinical setting, impaired cardiac hypoxia-inducible factor 1alpha activation and consequent reduced MIF expression may play an important role in the increased susceptibility to myocardial ischemia observed in older cardiac patients." @default.
• W2158498082 created "2016-06-24" @default.
• W2158498082 creator A5001664185 @default.
• W2158498082 creator A5007706452 @default.
• W2158498082 creator A5008065494 @default.
• W2158498082 creator A5020928977 @default.
• W2158498082 creator A5048715332 @default.
• W2158498082 creator A5052899991 @default.
• W2158498082 creator A5060491389 @default.
• W2158498082 creator A5064803348 @default.
• W2158498082 creator A5069557619 @default.
• W2158498082 creator A5079814738 @default.
• W2158498082 creator A5083981198 @default.
• W2158498082 creator A5088624555 @default.
• W2158498082 date "2010-07-20" @default.
• W2158498082 modified "2023-10-13" @default.
• W2158498082 title "Impaired Macrophage Migration Inhibitory Factor–AMP-Activated Protein Kinase Activation and Ischemic Recovery in the Senescent Heart" @default.
• W2158498082 cites W1483088512 @default.
• W2158498082 cites W1817253690 @default.
• W2158498082 cites W1940345635 @default.
• W2158498082 cites W1964002198 @default.
• W2158498082 cites W1973163466 @default.
• W2158498082 cites W1985343768 @default.
• W2158498082 cites W1990098076 @default.
• W2158498082 cites W2005800951 @default.
• W2158498082 cites W2005915142 @default.
• W2158498082 cites W2006096547 @default.
• W2158498082 cites W2027589607 @default.
• W2158498082 cites W2033052999 @default.
• W2158498082 cites W2037835822 @default.
• W2158498082 cites W2039411604 @default.
• W2158498082 cites W2043737958 @default.
• W2158498082 cites W2045697440 @default.
• W2158498082 cites W2073342055 @default.
• W2158498082 cites W2073534977 @default.
• W2158498082 cites W2076134751 @default.
• W2158498082 cites W2077834313 @default.
• W2158498082 cites W2078348450 @default.
• W2158498082 cites W2078629577 @default.
• W2158498082 cites W2081281066 @default.
• W2158498082 cites W2084294242 @default.
• W2158498082 cites W2094511058 @default.
• W2158498082 cites W2104611938 @default.
• W2158498082 cites W2114825009 @default.
• W2158498082 cites W2121766795 @default.
• W2158498082 cites W2125121177 @default.
• W2158498082 cites W2127583356 @default.
• W2158498082 cites W2129917446 @default.
• W2158498082 cites W2141885786 @default.
• W2158498082 cites W2147853633 @default.
• W2158498082 cites W2154587590 @default.
• W2158498082 cites W2171953578 @default.
• W2158498082 doi "https://doi.org/10.1161/circulationaha.110.953208" @default.
• W2158498082 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2907453" @default.
• W2158498082 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20606117" @default.
• W2158498082 hasPublicationYear "2010" @default.
• W2158498082 type Work @default.
• W2158498082 sameAs 2158498082 @default.
• W2158498082 citedByCount "147" @default.
• W2158498082 countsByYear W21584980822012 @default.
• W2158498082 countsByYear W21584980822013 @default.
• W2158498082 countsByYear W21584980822014 @default.
• W2158498082 countsByYear W21584980822015 @default.
• W2158498082 countsByYear W21584980822016 @default.
• W2158498082 countsByYear W21584980822017 @default.
• W2158498082 countsByYear W21584980822018 @default.
• W2158498082 countsByYear W21584980822019 @default.
• W2158498082 countsByYear W21584980822020 @default.
• W2158498082 countsByYear W21584980822021 @default.
• W2158498082 countsByYear W21584980822022 @default.
• W2158498082 countsByYear W21584980822023 @default.
• W2158498082 crossrefType "journal-article" @default.
• W2158498082 hasAuthorship W2158498082A5001664185 @default.
• W2158498082 hasAuthorship W2158498082A5007706452 @default.
• W2158498082 hasAuthorship W2158498082A5008065494 @default.
• W2158498082 hasAuthorship W2158498082A5020928977 @default.
• W2158498082 hasAuthorship W2158498082A5048715332 @default.
• W2158498082 hasAuthorship W2158498082A5052899991 @default.
• W2158498082 hasAuthorship W2158498082A5060491389 @default.
• W2158498082 hasAuthorship W2158498082A5064803348 @default.
• W2158498082 hasAuthorship W2158498082A5069557619 @default.
• W2158498082 hasAuthorship W2158498082A5079814738 @default.
• W2158498082 hasAuthorship W2158498082A5083981198 @default.
• W2158498082 hasAuthorship W2158498082A5088624555 @default.
• W2158498082 hasBestOaLocation W21584980821 @default.
• W2158498082 hasConcept C104177226 @default.
• W2158498082 hasConcept C126322002 @default.
• W2158498082 hasConcept C134018914 @default.
• W2158498082 hasConcept C170493617 @default.
• W2158498082 hasConcept C178790620 @default.
• W2158498082 hasConcept C184235292 @default.
• W2158498082 hasConcept C185592680 @default.
• W2158498082 hasConcept C2776780712 @default.
• W2158498082 hasConcept C2778690821 @default.
• W2158498082 hasConcept C2779311647 @default.
• W2158498082 hasConcept C2780124434 @default.
• W2158498082 hasConcept C522857546 @default.
• W2158498082 hasConcept C540031477 @default.

• next