Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158519579> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W2158519579 endingPage "1984" @default.
- W2158519579 startingPage "1980" @default.
- W2158519579 abstract "Topiramate, a sulfamate-substituted monosaccharide (2,3:4, 5-bis-O-(1-methylethylidene)-beta-D-fructopyranose sulfamate), is a new antiepileptic drug, which has been approved for adjunctive therapy in adult patients with partial-onset seizures. Liquid-liquid extraction followed by flow-injection negative-ion electrospray mass spectrometry was evaluated as a means for the quantitative analysis of Topiramate in human plasma. Prednisone (1,4-pregnadiene-17-alpha, 21-diol-3,11,20-trione [15 microg/mL]) was used as the internal standard because its solubility and molecular weight are similar to those of Topiramate. Calibration curves for Topiramate were linear over a range of 1 to 30 microg/mL plasma (signal-to-noise ratio >4) and were highly reliable (r(2) = 0.994). This approach offers several advantages: (i) the extraction of Topiramate from human plasma using chloroform is simple and reproducible; (ii) the quantitative determination of Topiramate, in the presence of an internal standard, by flow-injection negative-ion electrospray mass spectrometry with selected-ion recording, is rapid and accurate and does not require chromatographic separation; (iii) the assay possesses adequate sensitivity (2-25 microg/mL) for the quantitative analysis of Topiramate in plasma from patients." @default.
- W2158519579 created "2016-06-24" @default.
- W2158519579 creator A5026015787 @default.
- W2158519579 creator A5030942972 @default.
- W2158519579 date "1999-10-30" @default.
- W2158519579 modified "2023-09-23" @default.
- W2158519579 title "Rapid approach to the quantitative determination of Topiramate (2,3:4,5-bis-O-(1-methylethylidene)-β-D-fructopyranose sulfamate) in human plasma by liquid-liquid extraction and flow-injection negative-ion electrospray mass spectrometry" @default.
- W2158519579 cites W1977757868 @default.
- W2158519579 cites W1992199600 @default.
- W2158519579 cites W1996225226 @default.
- W2158519579 cites W2001200700 @default.
- W2158519579 cites W2008042616 @default.
- W2158519579 cites W2033751850 @default.
- W2158519579 cites W2056000225 @default.
- W2158519579 cites W2085756939 @default.
- W2158519579 cites W2165630646 @default.
- W2158519579 cites W4242724894 @default.
- W2158519579 doi "https://doi.org/10.1002/(sici)1097-0231(19991030)13:20<1980::aid-rcm741>3.0.co;2-c" @default.
- W2158519579 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10510408" @default.
- W2158519579 hasPublicationYear "1999" @default.
- W2158519579 type Work @default.
- W2158519579 sameAs 2158519579 @default.
- W2158519579 citedByCount "27" @default.
- W2158519579 countsByYear W21585195792013 @default.
- W2158519579 countsByYear W21585195792014 @default.
- W2158519579 countsByYear W21585195792015 @default.
- W2158519579 countsByYear W21585195792018 @default.
- W2158519579 countsByYear W21585195792021 @default.
- W2158519579 crossrefType "journal-article" @default.
- W2158519579 hasAuthorship W2158519579A5026015787 @default.
- W2158519579 hasAuthorship W2158519579A5030942972 @default.
- W2158519579 hasBestOaLocation W21585195791 @default.
- W2158519579 hasConcept C113196181 @default.
- W2158519579 hasConcept C162356407 @default.
- W2158519579 hasConcept C169760540 @default.
- W2158519579 hasConcept C185592680 @default.
- W2158519579 hasConcept C194451485 @default.
- W2158519579 hasConcept C2777683783 @default.
- W2158519579 hasConcept C2778186239 @default.
- W2158519579 hasConcept C31827203 @default.
- W2158519579 hasConcept C40684141 @default.
- W2158519579 hasConcept C43617362 @default.
- W2158519579 hasConcept C4725764 @default.
- W2158519579 hasConcept C86803240 @default.
- W2158519579 hasConcept C95986675 @default.
- W2158519579 hasConceptScore W2158519579C113196181 @default.
- W2158519579 hasConceptScore W2158519579C162356407 @default.
- W2158519579 hasConceptScore W2158519579C169760540 @default.
- W2158519579 hasConceptScore W2158519579C185592680 @default.
- W2158519579 hasConceptScore W2158519579C194451485 @default.
- W2158519579 hasConceptScore W2158519579C2777683783 @default.
- W2158519579 hasConceptScore W2158519579C2778186239 @default.
- W2158519579 hasConceptScore W2158519579C31827203 @default.
- W2158519579 hasConceptScore W2158519579C40684141 @default.
- W2158519579 hasConceptScore W2158519579C43617362 @default.
- W2158519579 hasConceptScore W2158519579C4725764 @default.
- W2158519579 hasConceptScore W2158519579C86803240 @default.
- W2158519579 hasConceptScore W2158519579C95986675 @default.
- W2158519579 hasIssue "20" @default.
- W2158519579 hasLocation W21585195791 @default.
- W2158519579 hasLocation W21585195792 @default.
- W2158519579 hasOpenAccess W2158519579 @default.
- W2158519579 hasPrimaryLocation W21585195791 @default.
- W2158519579 hasRelatedWork W165299446 @default.
- W2158519579 hasRelatedWork W1965060487 @default.
- W2158519579 hasRelatedWork W2004572792 @default.
- W2158519579 hasRelatedWork W2004645109 @default.
- W2158519579 hasRelatedWork W2008282167 @default.
- W2158519579 hasRelatedWork W2014605936 @default.
- W2158519579 hasRelatedWork W2042494227 @default.
- W2158519579 hasRelatedWork W2069623463 @default.
- W2158519579 hasRelatedWork W2352932869 @default.
- W2158519579 hasRelatedWork W3024778223 @default.
- W2158519579 hasVolume "13" @default.
- W2158519579 isParatext "false" @default.
- W2158519579 isRetracted "false" @default.
- W2158519579 magId "2158519579" @default.
- W2158519579 workType "article" @default.