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- W2158538315 endingPage "S281" @default.
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- W2158538315 abstract "Glucocorticoids have potent, pleiotropic effects on the immune system that can predispose patients to developing life-threatening invasive aspergillosis (IA). While the exact prevalence and attributable mortality of IA in glucocorticoid-treated patients is difficult to estimate, Aspergillus species are significant pathogens in patients that require prolonged high-dose glucocorticoid therapy including multiple myeloma, collagen vascular diseases, or recipients of solid organ/hematopoietic transplantation. Experimental animal models and autopsy series have revealed important differences in the pathology of aspergillosis between glucocorticoid-treated and neutropenic patients. Although neutropenic hosts develop infection characterized by extensive angioinvasion, hemorrhagic thrombosis and necrosis with a high fungal burden, glucocorticoid-immunosuppressed hosts present with infection dominated by extensive necrosis, less angioinvasion, and a lower fungal burden suggestive of an inflammation-driven pathology. These pathobiological differences may have important implications for the diagnosis and treatment approaches of IA in glucocorticoid-treated patients." @default.
- W2158538315 created "2016-06-24" @default.
- W2158538315 creator A5041039527 @default.
- W2158538315 creator A5066067579 @default.
- W2158538315 date "2009-01-01" @default.
- W2158538315 modified "2023-10-10" @default.
- W2158538315 title "Invasive aspergillosis in glucocorticoid-treated patients" @default.
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- W2158538315 cites W1964565115 @default.
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- W2158538315 cites W1973512045 @default.
- W2158538315 cites W1976925504 @default.
- W2158538315 cites W1977137895 @default.
- W2158538315 cites W1980672655 @default.
- W2158538315 cites W1980921693 @default.
- W2158538315 cites W1981231626 @default.
- W2158538315 cites W1982964950 @default.
- W2158538315 cites W1992232557 @default.
- W2158538315 cites W2002981480 @default.
- W2158538315 cites W2003948993 @default.
- W2158538315 cites W2011990652 @default.
- W2158538315 cites W2012351120 @default.
- W2158538315 cites W2013523431 @default.
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- W2158538315 cites W2020369755 @default.
- W2158538315 cites W2024470090 @default.
- W2158538315 cites W2024624099 @default.
- W2158538315 cites W2037539696 @default.
- W2158538315 cites W2038112945 @default.
- W2158538315 cites W2039267791 @default.
- W2158538315 cites W2041414113 @default.
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- W2158538315 cites W2049627497 @default.
- W2158538315 cites W2052187913 @default.
- W2158538315 cites W2056222459 @default.
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- W2158538315 cites W2088935771 @default.
- W2158538315 cites W2089244130 @default.
- W2158538315 cites W2093731245 @default.
- W2158538315 cites W2093919412 @default.
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- W2158538315 cites W2146361081 @default.
- W2158538315 cites W2147605389 @default.
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- W2158538315 cites W2163710030 @default.
- W2158538315 cites W2164520737 @default.
- W2158538315 cites W2166310628 @default.
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- W2158538315 doi "https://doi.org/10.1080/13693780802227159" @default.
- W2158538315 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18654923" @default.
- W2158538315 hasPublicationYear "2009" @default.
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