FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158541796> ?p ?o ?g. }

• W2158541796 endingPage "3401" @default.
• W2158541796 startingPage "3394" @default.
• W2158541796 abstract "ABSTRACT T-bet (T-box expressed in T cells) and GATA-3 are transcription factors that play a critical role in the development of Th1 and Th2 cells, as do genes of the SOCS (suppressor of cytokine signaling) family, albeit indirectly. Another transcription factor, Foxp3, is a master regulator of natural regulatory T cells (Tregs). To identify the role of these factors in impaired Th1 responses of patent filarial infection, analysis of cytokine, SOCS, and transcription factor mRNA expression was performed on purified T cells of filaria-infected individuals ( n = 6) and uninfected controls ( n = 6). As expected (and in contrast to cells of uninfected individuals), there was a significant depression of gamma interferon (IFN-γ) and a concomitant increase in interleukin-4 (IL-4), IL-5, and IL-10 mRNA expression following stimulation with parasite antigen (BmA) but not with a polyclonal T-cell (anti-CD3) stimulus. T-bet (but not GATA-3) was expressed at significantly lower levels in cells of filaria-infected individuals in response to BmA compared with those from the uninfected group, accounting, at least partially, for the diminished IFN-γ expression. Second, we found no significant differences in expression of Foxp3 between the two groups, although induction of Foxp3 expression correlated with induced expression levels of IL-10, implicating Tregs in the IL-10 expression seen. Finally, parasite-specific T-cell expression of SOCS-1, SOCS-5, and SOCS-7 was significantly diminished among infected patients; in contrast, expression of SOCS-3 increased. Our data therefore indicate that the impaired Th1 responses observed in patent lymphatic filariasis are associated with decreased expression of T-bet, SOCS-1, SOCS-5, and SOCS-7 and increased expression of SOCS-3 in T cells." @default.
• W2158541796 created "2016-06-24" @default.
• W2158541796 creator A5040012220 @default.
• W2158541796 creator A5063107764 @default.
• W2158541796 creator A5077213465 @default.
• W2158541796 date "2005-06-01" @default.
• W2158541796 modified "2023-09-25" @default.
• W2158541796 title "Transcriptional Control of Impaired Th1 Responses in Patent Lymphatic Filariasis by T-Box Expressed in T Cells and Suppressor of Cytokine Signaling Genes" @default.
• W2158541796 cites W1482432582 @default.
• W2158541796 cites W1532354797 @default.
• W2158541796 cites W1656645373 @default.
• W2158541796 cites W1967261754 @default.
• W2158541796 cites W1971303271 @default.
• W2158541796 cites W1977701102 @default.
• W2158541796 cites W1980110512 @default.
• W2158541796 cites W1983824821 @default.
• W2158541796 cites W1988369300 @default.
• W2158541796 cites W1989487909 @default.
• W2158541796 cites W2002726823 @default.
• W2158541796 cites W2006843277 @default.
• W2158541796 cites W2010470756 @default.
• W2158541796 cites W2012198462 @default.
• W2158541796 cites W2019568536 @default.
• W2158541796 cites W2022828031 @default.
• W2158541796 cites W2027699993 @default.
• W2158541796 cites W2038449026 @default.
• W2158541796 cites W2058593261 @default.
• W2158541796 cites W2071069822 @default.
• W2158541796 cites W2088118252 @default.
• W2158541796 cites W2098692676 @default.
• W2158541796 cites W2123760021 @default.
• W2158541796 cites W2127379971 @default.
• W2158541796 cites W2128475635 @default.
• W2158541796 cites W2141904666 @default.
• W2158541796 cites W2163406329 @default.
• W2158541796 cites W2165449045 @default.
• W2158541796 cites W2737785069 @default.
• W2158541796 doi "https://doi.org/10.1128/iai.73.6.3394-3401.2005" @default.
• W2158541796 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1111868" @default.
• W2158541796 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15908366" @default.
• W2158541796 hasPublicationYear "2005" @default.
• W2158541796 type Work @default.
• W2158541796 sameAs 2158541796 @default.
• W2158541796 citedByCount "32" @default.
• W2158541796 countsByYear W21585417962012 @default.
• W2158541796 countsByYear W21585417962013 @default.
• W2158541796 countsByYear W21585417962014 @default.
• W2158541796 countsByYear W21585417962015 @default.
• W2158541796 countsByYear W21585417962016 @default.
• W2158541796 countsByYear W21585417962017 @default.
• W2158541796 countsByYear W21585417962018 @default.
• W2158541796 countsByYear W21585417962020 @default.
• W2158541796 countsByYear W21585417962021 @default.
• W2158541796 crossrefType "journal-article" @default.
• W2158541796 hasAuthorship W2158541796A5040012220 @default.
• W2158541796 hasAuthorship W2158541796A5063107764 @default.
• W2158541796 hasAuthorship W2158541796A5077213465 @default.
• W2158541796 hasBestOaLocation W21585417962 @default.
• W2158541796 hasConcept C104317684 @default.
• W2158541796 hasConcept C126042315 @default.
• W2158541796 hasConcept C203014093 @default.
• W2158541796 hasConcept C2776090121 @default.
• W2158541796 hasConcept C2778690821 @default.
• W2158541796 hasConcept C2778923194 @default.
• W2158541796 hasConcept C2779727006 @default.
• W2158541796 hasConcept C54355233 @default.
• W2158541796 hasConcept C62478195 @default.
• W2158541796 hasConcept C86339819 @default.
• W2158541796 hasConcept C86803240 @default.
• W2158541796 hasConcept C8891405 @default.
• W2158541796 hasConcept C95444343 @default.
• W2158541796 hasConceptScore W2158541796C104317684 @default.
• W2158541796 hasConceptScore W2158541796C126042315 @default.
• W2158541796 hasConceptScore W2158541796C203014093 @default.
• W2158541796 hasConceptScore W2158541796C2776090121 @default.
• W2158541796 hasConceptScore W2158541796C2778690821 @default.
• W2158541796 hasConceptScore W2158541796C2778923194 @default.
• W2158541796 hasConceptScore W2158541796C2779727006 @default.
• W2158541796 hasConceptScore W2158541796C54355233 @default.
• W2158541796 hasConceptScore W2158541796C62478195 @default.
• W2158541796 hasConceptScore W2158541796C86339819 @default.
• W2158541796 hasConceptScore W2158541796C86803240 @default.
• W2158541796 hasConceptScore W2158541796C8891405 @default.
• W2158541796 hasConceptScore W2158541796C95444343 @default.
• W2158541796 hasIssue "6" @default.
• W2158541796 hasLocation W21585417961 @default.
• W2158541796 hasLocation W21585417962 @default.
• W2158541796 hasLocation W21585417963 @default.
• W2158541796 hasLocation W21585417964 @default.
• W2158541796 hasLocation W21585417965 @default.
• W2158541796 hasLocation W21585417966 @default.
• W2158541796 hasOpenAccess W2158541796 @default.
• W2158541796 hasPrimaryLocation W21585417961 @default.
• W2158541796 hasRelatedWork W181678093 @default.
• W2158541796 hasRelatedWork W2005666125 @default.
• W2158541796 hasRelatedWork W2047209980 @default.
• W2158541796 hasRelatedWork W2078282038 @default.
• W2158541796 hasRelatedWork W2366649094 @default.

• next