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• W2158549846 abstract "Diabet. Med. 28, 218–222 (2011) Abstract Aim This study examined the effects of reductions to pre‐exercise rapid‐acting insulin dose on changes in blood beta‐hydroxybutyrate, glucose, acid‐base balance and counter‐regulatory hormone responses to prolonged running in individuals with Type 1 diabetes. Methods Following ethical approval, seven participants with Type 1 diabetes (34 ± 2 years, BMI 27 ± 1 kg/m 2 ) completed this study. After preliminary testing, participants attended the laboratory four times, each time consuming a 1.12MJ meal (60 g carbohydrate, 2 g fat, 2 g protein), with randomized amounts of their rapid‐acting insulin: Full dose (mean 7.3 ± 0.2 units), 75% dose (mean 5.4 ± 0.1 units), 50% dose (mean 3.7 ± 0.1 units) or 25% dose (mean 1.8 ± 0.1 units). After 2‐h rest, participants completed 45 min running at 70 ± 1% peak rate of oxygen consumption (VO 2peak ). Blood metabolites and hormones were recorded over the 2‐h rest and 3‐h recovery. Data were analysed using repeated‐measures ANOVA. Results Serum insulin peaked at 60 min in all conditions and was lowest after 25% insulin dose compared with full dose ( P = 0.03). After the 25% insulin dose immediately pre‐exercise glucose concentration was higher than after the full or 50% dose ( P < 0.05). Resting beta‐hydroxybutyrate gradually decreased during 2‐h rest ( P < 0.05) with a similar post‐exercise peak of beta‐hydroxybutyrate at 3 h ( P > 0.05). Post‐exercise blood pH increased for 5 min to a similar extent with all insulin doses , but the rise with the 25% dose was less compared with the full dose ( P = 0.01). Blood lactate and plasma catecholamine s increased after running similarly with all insulin reduction conditions ( P < 0.05). Blood glucose area under the curve (BG auc ) after the 25% insulin dose was greater than after the 75% dose ( P = 0.02). Conclusion Ketogenesis following running was not influenced by reductions in pre‐exercise rapid‐acting insulin dose. This important preparatory strategy aids preservation of blood glucose but poses no greater risk to exercise‐induced ketone body formation." @default.
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• W2158549846 date "2011-01-11" @default.
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• W2158549846 title "Impact of pre-exercise rapid-acting insulin reductions on ketogenesis following running in Type 1 diabetes" @default.
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• W2158549846 doi "https://doi.org/10.1111/j.1464-5491.2010.03162.x" @default.
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