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- W2158551458 endingPage "R51" @default.
- W2158551458 startingPage "R51" @default.
- W2158551458 abstract "The position of a nucleosome, both translational along the DNA molecule and rotational between the histone core and the DNA, is controlled by many factors, including the regular occurrence of specific dinucleotides with a period of approximately 10 bp, important for the rotational setting of the DNA around the histone octamer.We show that such a 10 bp periodic signal of purine-purine dinucleotides occurs in phase with the transcription start site (TSS) of human genes and is centered on the position of the first (+1) nucleosome downstream of the TSS. These data support a direct link between transcription and the rotational setting of the nucleosome. The periodic signal is most prevalent in genes that contain CpG islands that are expressed at low levels in a tissue-specific manner and are involved in the control of transcription.These results, together with several lines of evidence from the recent literature, support a new model whereby the +1 nucleosome could be more efficiently disassembled from gene promoters by H3K56 acetylation marks if the periodic signal specifies an optimal rotational setting." @default.
- W2158551458 created "2016-06-24" @default.
- W2158551458 creator A5004207859 @default.
- W2158551458 creator A5005470646 @default.
- W2158551458 date "2010-01-01" @default.
- W2158551458 modified "2023-10-18" @default.
- W2158551458 title "Nucleosome rotational setting is associated with transcriptional regulation in promoters of tissue-specific human genes" @default.
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- W2158551458 doi "https://doi.org/10.1186/gb-2010-11-5-r51" @default.
- W2158551458 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2898081" @default.
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