FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158562859> ?p ?o ?g. }

• W2158562859 endingPage "5356" @default.
• W2158562859 startingPage "5349" @default.
• W2158562859 abstract "Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product/cytokine that catalyzes a step in glycolysis and gluconeogenesis, and acts as a multifunctional cytokine associated with aggressive tumors. PGI/AMF has been correlated significantly with breast cancer progression and poor prognosis in breast cancer. We show here that ectopic expression of PGI/AMF induced epithelial-to-mesenchymal transition (EMT) in MCF10A normal human breast epithelial cells, and inhibition of PGI/AMF expression triggered mesenchymal-to-epithelial transition (MET) in aggressive mesenchymal-type human breast cancer MDA-MB-231 cells. EMT in MCF10A cells was shown by morphologic changes and loss of E-cadherin/beta-catenin-mediated cell-cell adhesion, which is concomitant with the induction of the E-cadherin transcriptional repressor Snail and proteosome-dependent degradation of beta-catenin protein. Molecular analysis showed that PGI/AMF suppressed epithelial marker expressions and enhanced mesenchymal marker expressions. Silencing of PGI/AMF expression by RNA interference in MDA-MB-231 cells induced the reverse processes of EMT including altered cell shape, gain of epithelial marker, and reduction of mesenchymal marker, e.g., MET. Taken together, the results show the involvement of PGI/AMF in both EMT and MET: overexpression of PGI/AMF induces EMT in normal breast epithelial cells and reduction of PGI/AMF expression led to MET in aggressive breast cancer cells. These results suggest for the first time that PGI/AMF is a key gene to both EMT in the initiating step of cancer metastasis and MET in the later stage of metastasis during breast cancer progression." @default.
• W2158562859 created "2016-06-24" @default.
• W2158562859 creator A5010903945 @default.
• W2158562859 creator A5032550342 @default.
• W2158562859 creator A5040630146 @default.
• W2158562859 date "2009-07-01" @default.
• W2158562859 modified "2023-10-15" @default.
• W2158562859 title "Phosphoglucose Isomerase/Autocrine Motility Factor Mediates Epithelial and Mesenchymal Phenotype Conversions in Breast Cancer" @default.
• W2158562859 cites W1480706413 @default.
• W2158562859 cites W1510150165 @default.
• W2158562859 cites W1532353086 @default.
• W2158562859 cites W1972521865 @default.
• W2158562859 cites W1976736011 @default.
• W2158562859 cites W1980623424 @default.
• W2158562859 cites W1995378553 @default.
• W2158562859 cites W1997527312 @default.
• W2158562859 cites W2000487846 @default.
• W2158562859 cites W2000773327 @default.
• W2158562859 cites W2007707744 @default.
• W2158562859 cites W2018471228 @default.
• W2158562859 cites W2025647419 @default.
• W2158562859 cites W2032930150 @default.
• W2158562859 cites W2035131806 @default.
• W2158562859 cites W2068948271 @default.
• W2158562859 cites W2069806246 @default.
• W2158562859 cites W2074710036 @default.
• W2158562859 cites W2076583198 @default.
• W2158562859 cites W2077462602 @default.
• W2158562859 cites W2079016331 @default.
• W2158562859 cites W2082055110 @default.
• W2158562859 cites W2086641174 @default.
• W2158562859 cites W2087367170 @default.
• W2158562859 cites W2105762021 @default.
• W2158562859 cites W2134203671 @default.
• W2158562859 cites W2138924822 @default.
• W2158562859 cites W2140551998 @default.
• W2158562859 cites W2149675687 @default.
• W2158562859 cites W2150449422 @default.
• W2158562859 cites W2160992291 @default.
• W2158562859 cites W2165811484 @default.
• W2158562859 cites W2165901622 @default.
• W2158562859 cites W2165987163 @default.
• W2158562859 cites W2166591651 @default.
• W2158562859 cites W2167391679 @default.
• W2158562859 cites W2167841373 @default.
• W2158562859 cites W2239090104 @default.
• W2158562859 cites W2417532218 @default.
• W2158562859 cites W2887635189 @default.
• W2158562859 doi "https://doi.org/10.1158/0008-5472.can-09-0488" @default.
• W2158562859 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2875197" @default.
• W2158562859 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19531650" @default.
• W2158562859 hasPublicationYear "2009" @default.
• W2158562859 type Work @default.
• W2158562859 sameAs 2158562859 @default.
• W2158562859 citedByCount "68" @default.
• W2158562859 countsByYear W21585628592012 @default.
• W2158562859 countsByYear W21585628592013 @default.
• W2158562859 countsByYear W21585628592014 @default.
• W2158562859 countsByYear W21585628592015 @default.
• W2158562859 countsByYear W21585628592016 @default.
• W2158562859 countsByYear W21585628592017 @default.
• W2158562859 countsByYear W21585628592018 @default.
• W2158562859 countsByYear W21585628592019 @default.
• W2158562859 countsByYear W21585628592020 @default.
• W2158562859 countsByYear W21585628592021 @default.
• W2158562859 countsByYear W21585628592022 @default.
• W2158562859 countsByYear W21585628592023 @default.
• W2158562859 crossrefType "journal-article" @default.
• W2158562859 hasAuthorship W2158562859A5010903945 @default.
• W2158562859 hasAuthorship W2158562859A5032550342 @default.
• W2158562859 hasAuthorship W2158562859A5040630146 @default.
• W2158562859 hasBestOaLocation W21585628591 @default.
• W2158562859 hasConcept C121608353 @default.
• W2158562859 hasConcept C128240485 @default.
• W2158562859 hasConcept C198826908 @default.
• W2158562859 hasConcept C2779013556 @default.
• W2158562859 hasConcept C502942594 @default.
• W2158562859 hasConcept C530470458 @default.
• W2158562859 hasConcept C54355233 @default.
• W2158562859 hasConcept C555283112 @default.
• W2158562859 hasConcept C76419328 @default.
• W2158562859 hasConcept C81885089 @default.
• W2158562859 hasConcept C86803240 @default.
• W2158562859 hasConcept C95444343 @default.
• W2158562859 hasConcept C96232424 @default.
• W2158562859 hasConceptScore W2158562859C121608353 @default.
• W2158562859 hasConceptScore W2158562859C128240485 @default.
• W2158562859 hasConceptScore W2158562859C198826908 @default.
• W2158562859 hasConceptScore W2158562859C2779013556 @default.
• W2158562859 hasConceptScore W2158562859C502942594 @default.
• W2158562859 hasConceptScore W2158562859C530470458 @default.
• W2158562859 hasConceptScore W2158562859C54355233 @default.
• W2158562859 hasConceptScore W2158562859C555283112 @default.
• W2158562859 hasConceptScore W2158562859C76419328 @default.
• W2158562859 hasConceptScore W2158562859C81885089 @default.
• W2158562859 hasConceptScore W2158562859C86803240 @default.
• W2158562859 hasConceptScore W2158562859C95444343 @default.
• W2158562859 hasConceptScore W2158562859C96232424 @default.

• next