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- W2158563602 abstract "Abstract Despite the widespread use of replication-incompetent recombinant adenovirus (Ad) vectors as candidate vaccine platforms, the mechanism by which these vectors elicit CD8+ T cell responses remains poorly understood. Our data demonstrate that induction and maintenance of CD8+ T cell responses by Ad vector immunization is longitudinally dependent on CD4+ T cell help for a prolonged period. Depletion of CD4+ T cells in wild type mice within the first 8 d following Ad immunization resulted in dramatically reduced induction of Ag-specific CD8+ T cells, decreased T-bet and eomesodermin expression, impaired KLRG1+ effector differentiation, and atypical expression of the memory markers CD127, CD27, and CD62L. Moreover, these CD8+ T cells failed to protect against a lethal recombinant Listeria monocytogenes challenge. Depletion of CD4+ T cells between weeks 1 and 4 following immunization resulted in increased contraction of memory CD8+ T cells. These data demonstrate a prolonged temporal requirement for CD4+ T cell help for vaccine-elicited CD8+ T cell responses in mice. These findings have important implications in the design of vaccines aimed at eliciting CD8+ T cell responses and may provide insight into the impaired immunogenicity of vaccines in the context of AIDS and other CD4+ T cell immune deficiencies." @default.
- W2158563602 created "2016-06-24" @default.
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- W2158563602 date "2014-06-01" @default.
- W2158563602 modified "2023-10-01" @default.
- W2158563602 title "Longitudinal Requirement for CD4+ T Cell Help for Adenovirus Vector–Elicited CD8+ T Cell Responses" @default.
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- W2158563602 cites W1501518736 @default.
- W2158563602 cites W1553665600 @default.
- W2158563602 cites W1591146540 @default.
- W2158563602 cites W1669165205 @default.
- W2158563602 cites W1678167583 @default.
- W2158563602 cites W1760886018 @default.
- W2158563602 cites W1819121222 @default.
- W2158563602 cites W1924636867 @default.
- W2158563602 cites W1931750338 @default.
- W2158563602 cites W1963759157 @default.
- W2158563602 cites W1965175217 @default.
- W2158563602 cites W1967261754 @default.
- W2158563602 cites W1974842026 @default.
- W2158563602 cites W1976785514 @default.
- W2158563602 cites W1983633308 @default.
- W2158563602 cites W1985027512 @default.
- W2158563602 cites W1985294654 @default.
- W2158563602 cites W1987337968 @default.
- W2158563602 cites W1997241837 @default.
- W2158563602 cites W1999089101 @default.
- W2158563602 cites W2004663864 @default.
- W2158563602 cites W2005154465 @default.
- W2158563602 cites W2011873300 @default.
- W2158563602 cites W2016910859 @default.
- W2158563602 cites W2019214329 @default.
- W2158563602 cites W2021936785 @default.
- W2158563602 cites W2029128444 @default.
- W2158563602 cites W2043793366 @default.
- W2158563602 cites W2047306911 @default.
- W2158563602 cites W2051108441 @default.
- W2158563602 cites W2051842447 @default.
- W2158563602 cites W2052100442 @default.
- W2158563602 cites W2056100438 @default.
- W2158563602 cites W2056786987 @default.
- W2158563602 cites W2060828809 @default.
- W2158563602 cites W2062872787 @default.
- W2158563602 cites W2067422236 @default.
- W2158563602 cites W2067701958 @default.
- W2158563602 cites W2067808326 @default.
- W2158563602 cites W2076534074 @default.
- W2158563602 cites W2077149270 @default.
- W2158563602 cites W2085345039 @default.
- W2158563602 cites W2095862992 @default.
- W2158563602 cites W2098617460 @default.
- W2158563602 cites W2101419213 @default.
- W2158563602 cites W2101844985 @default.
- W2158563602 cites W2105249005 @default.
- W2158563602 cites W2108709588 @default.
- W2158563602 cites W2112612529 @default.
- W2158563602 cites W2114761018 @default.
- W2158563602 cites W2118342395 @default.
- W2158563602 cites W2119319172 @default.
- W2158563602 cites W2119545820 @default.
- W2158563602 cites W2123052625 @default.
- W2158563602 cites W2134637336 @default.
- W2158563602 cites W2137872075 @default.
- W2158563602 cites W2145923451 @default.
- W2158563602 cites W2146641952 @default.
- W2158563602 cites W2147699808 @default.
- W2158563602 cites W2149705618 @default.
- W2158563602 cites W2150545218 @default.
- W2158563602 cites W2151130810 @default.
- W2158563602 cites W2151902657 @default.
- W2158563602 cites W2155025120 @default.
- W2158563602 cites W2155803497 @default.
- W2158563602 cites W2161293449 @default.
- W2158563602 cites W2166835758 @default.
- W2158563602 cites W2169962588 @default.
- W2158563602 cites W2171709731 @default.
- W2158563602 cites W2171986697 @default.
- W2158563602 cites W2293648610 @default.
- W2158563602 cites W2409996633 @default.
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- W2158563602 doi "https://doi.org/10.4049/jimmunol.1302806" @default.
- W2158563602 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4025612" @default.
- W2158563602 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24778441" @default.
- W2158563602 hasPublicationYear "2014" @default.
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