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• W2158565718 startingPage "E964" @default.
• W2158565718 abstract "Activation of autophagy in skeletal muscle has been reported in response to endurance exercise and food deprivation independently. The purpose of this study was to evaluate whether autophagy was more activated when both stimuli were combined, namely when endurance exercise was performed in a fasted rather than a fed state. Mice performed a low-intensity running exercise (10 m/min for 90min) in both dietary states after which the gastrocnemius muscles were removed. LC3b-II, a marker of autophagosome presence, increased in both conditions, but the increase was higher in the fasted state. Other protein markers of autophagy, like Gabarapl1-II and Atg12 conjugated form as well as mRNA of Lc3b, Gabarapl1, and p62/Sqstm1 were increased only when exercise was performed in a fasted state. The larger activation of autophagy by exercise in a fasted state was associated with a larger decrease in plasma insulin and phosphorylation of Akt Ser473 , Akt Thr308 , FoxO3a Thr32 , and ULK1 Ser757 . AMPKα Thr172 , ULK1 Ser317 , and ULK1 Ser555 remained unchanged in both conditions, whereas p38 Thr180/Tyr182 increased during exercise to a similar extent in the fasted and fed conditions. The marker of mitochondrial fission DRP1 Ser616 was increased by exercise independently of the nutritional status. Changes in mitophagy markers BNIP3 and Parkin suggest that mitophagy was increased during exercise in the fasted state. In conclusion, our results highlight a major implication of the insulin-Akt-mTOR pathway and its downstream targets FoxO3a and ULK1 in the larger activation of autophagy observed when exercise is performed in a fasted state compared with a fed state." @default.
• W2158565718 created "2016-06-24" @default.
• W2158565718 creator A5001010398 @default.
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• W2158565718 date "2013-10-15" @default.
• W2158565718 modified "2023-10-02" @default.
• W2158565718 title "Higher activation of autophagy in skeletal muscle of mice during endurance exercise in the fasted state" @default.
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• W2158565718 doi "https://doi.org/10.1152/ajpendo.00270.2013" @default.
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