FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158574257> ?p ?o ?g. }

• W2158574257 endingPage "2641" @default.
• W2158574257 startingPage "2628" @default.
• W2158574257 abstract "With a simple tandem iterated sequence, the carboxyl terminal domain (CTD) of eukaryotic RNA polymerase II (RNAP II) serves as the central coordinator of mRNA synthesis by harmonizing a diversity of sequential interactions with transcription and processing factors. Despite intense research interest, many key questions regarding functional and evolutionary constraints on the CTD remain unanswered; for example, what selects for the canonical heptad sequence, its tandem array across organismal diversity, and constant CTD length within given species and finally and how a sequence-identical, repetitive structure can orchestrate a diversity of simultaneous and sequential, stage-dependent interactions with both modifying enzymes and binding partners? Here we examine comparative sequence evolution of 58 RNAP II CTDs from diverse taxa representing all six major eukaryotic supergroups and employ integrated evolutionary genetic, biochemical, and biophysical analyses of the yeast CTD to further clarify how this repetitive sequence must be organized for optimal RNAP II function. We find that the CTD is composed of indivisible and independent functional units that span diheptapeptides and not only a flexible conformation around each unit but also an elastic overall structure is required. More remarkably, optimal CTD function always is achieved at approximately wild-type CTD length rather than number of functional units, regardless of the characteristics of the sequence present. Our combined observations lead us to advance an updated CTD working model, in which functional, and therefore, evolutionary constraints require a flexible CTD conformation determined by the CTD sequence and tandem register to accommodate the diversity of CTD-protein interactions and a specific CTD length rather than number of functional units to correctly order and organize global CTD-protein interactions. Patterns of conservation of these features across evolutionary diversity have important implications for comparative RNAP II function in eukaryotes and can more clearly direct specific research on CTD function in currently understudied organisms." @default.
• W2158574257 created "2016-06-24" @default.
• W2158574257 creator A5008512221 @default.
• W2158574257 creator A5054455401 @default.
• W2158574257 creator A5071663193 @default.
• W2158574257 creator A5086960898 @default.
• W2158574257 date "2010-06-17" @default.
• W2158574257 modified "2023-10-02" @default.
• W2158574257 title "Genetic Organization, Length Conservation, and Evolution of RNA Polymerase II Carboxyl-Terminal Domain" @default.
• W2158574257 cites W1494014375 @default.
• W2158574257 cites W1563156486 @default.
• W2158574257 cites W1954289976 @default.
• W2158574257 cites W1963600172 @default.
• W2158574257 cites W1970661451 @default.
• W2158574257 cites W1972808686 @default.
• W2158574257 cites W1975948611 @default.
• W2158574257 cites W1981930838 @default.
• W2158574257 cites W1984435444 @default.
• W2158574257 cites W1988904557 @default.
• W2158574257 cites W1989878371 @default.
• W2158574257 cites W1993120341 @default.
• W2158574257 cites W1999532778 @default.
• W2158574257 cites W2002269040 @default.
• W2158574257 cites W2006931677 @default.
• W2158574257 cites W2007537829 @default.
• W2158574257 cites W2008809596 @default.
• W2158574257 cites W2009444548 @default.
• W2158574257 cites W2021094809 @default.
• W2158574257 cites W2021912377 @default.
• W2158574257 cites W2028469737 @default.
• W2158574257 cites W2030980795 @default.
• W2158574257 cites W2031390327 @default.
• W2158574257 cites W2040367656 @default.
• W2158574257 cites W2045959839 @default.
• W2158574257 cites W2049858249 @default.
• W2158574257 cites W2051231585 @default.
• W2158574257 cites W2054084236 @default.
• W2158574257 cites W2059023146 @default.
• W2158574257 cites W2060323540 @default.
• W2158574257 cites W2061411850 @default.
• W2158574257 cites W2067584429 @default.
• W2158574257 cites W2076701374 @default.
• W2158574257 cites W2079151217 @default.
• W2158574257 cites W2088343433 @default.
• W2158574257 cites W2089348831 @default.
• W2158574257 cites W2101424708 @default.
• W2158574257 cites W2109659322 @default.
• W2158574257 cites W2113270377 @default.
• W2158574257 cites W2113327117 @default.
• W2158574257 cites W2119284763 @default.
• W2158574257 cites W2121649903 @default.
• W2158574257 cites W2126912623 @default.
• W2158574257 cites W2135001377 @default.
• W2158574257 cites W2140448223 @default.
• W2158574257 cites W2141004015 @default.
• W2158574257 cites W2146986827 @default.
• W2158574257 cites W2149920358 @default.
• W2158574257 cites W2157087271 @default.
• W2158574257 cites W2171119496 @default.
• W2158574257 cites W2293975284 @default.
• W2158574257 cites W3103717309 @default.
• W2158574257 cites W758429231 @default.
• W2158574257 doi "https://doi.org/10.1093/molbev/msq151" @default.
• W2158574257 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2981489" @default.
• W2158574257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20558594" @default.
• W2158574257 hasPublicationYear "2010" @default.
• W2158574257 type Work @default.
• W2158574257 sameAs 2158574257 @default.
• W2158574257 citedByCount "54" @default.
• W2158574257 countsByYear W21585742572012 @default.
• W2158574257 countsByYear W21585742572013 @default.
• W2158574257 countsByYear W21585742572014 @default.
• W2158574257 countsByYear W21585742572015 @default.
• W2158574257 countsByYear W21585742572016 @default.
• W2158574257 countsByYear W21585742572017 @default.
• W2158574257 countsByYear W21585742572018 @default.
• W2158574257 countsByYear W21585742572019 @default.
• W2158574257 countsByYear W21585742572020 @default.
• W2158574257 countsByYear W21585742572021 @default.
• W2158574257 countsByYear W21585742572023 @default.
• W2158574257 crossrefType "journal-article" @default.
• W2158574257 hasAuthorship W2158574257A5008512221 @default.
• W2158574257 hasAuthorship W2158574257A5054455401 @default.
• W2158574257 hasAuthorship W2158574257A5071663193 @default.
• W2158574257 hasAuthorship W2158574257A5086960898 @default.
• W2158574257 hasBestOaLocation W21585742572 @default.
• W2158574257 hasConcept C101762097 @default.
• W2158574257 hasConcept C104317684 @default.
• W2158574257 hasConcept C111368507 @default.
• W2158574257 hasConcept C125533998 @default.
• W2158574257 hasConcept C127313418 @default.
• W2158574257 hasConcept C138885662 @default.
• W2158574257 hasConcept C141231307 @default.
• W2158574257 hasConcept C150194340 @default.
• W2158574257 hasConcept C167625842 @default.
• W2158574257 hasConcept C179926584 @default.
• W2158574257 hasConcept C199216141 @default.
• W2158574257 hasConcept C27149982 @default.

• next