FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158582016> ?p ?o ?g. }

• W2158582016 endingPage "467" @default.
• W2158582016 startingPage "461" @default.
• W2158582016 abstract "Glucocorticoids are considered the main treatment option for chronic rhinosinusitis with nasal polyps (CRSwNP), but their effect rate ranges from 60.9% to 80%. Novel therapeutic means should be studied. The purpose of this study was to investigate the expression of Orai1 in nasal polyps (NPs) and the influence of intervention of Orai1 on NPs after in vitro treatment of 2-aminoethoxydiphenyl borate (2-APB).Prospective cross-sectional study.University hospital.Nasal biopsy samples were obtained from normal subjects or subjects with CRSwNP. We studied the localization of Orai1 protein in NPs by using immunohistochemistry. Then these tissues in cultures were maintained in the absence or presence of dexamethasone (DEX) or 2-APB. Orai1 was examined by Western blot, enzyme-linked immunosorbent assay (ELISA), and real-time reverse transcription-polymerase chain reaction (RT-PCR). Inflammatory mediators including interleukin (IL)-1β, IL-5, eosinophil cation protein (ECP), leukotriene (LT)C4, interferon (IFN)-γ, and dermatophagoides pteronyssinus (DP)-specific immunoglobulin E (sIgE) as well as mucins (MUCs) including MUC5B and MUC7 in cultures were analyzed with ELISA and real-time RT-PCR.The expression of Orai1 was localized to cytoplasmic membrane of inflammatory cells and submucosal glandular cells and was upregulated in NPs compared with normal nasal mucosa. Orai1 was decreased in NPs after in vitro treatment of 2-APB but not after DEX intervention. The levels of inflammatory mediators and mucins were reduced more after 2-APB treatment when compared with those after DEX treatment.Orai1 may play crucial roles in NP formation, and the intervention of Orai1 may inhibit NP development." @default.
• W2158582016 created "2016-06-24" @default.
• W2158582016 creator A5015860750 @default.
• W2158582016 creator A5037605712 @default.
• W2158582016 creator A5038336908 @default.
• W2158582016 creator A5040154477 @default.
• W2158582016 date "2015-06-17" @default.
• W2158582016 modified "2023-09-27" @default.
• W2158582016 title "In Vitro Treatment with 2-APB Inhibits the Inflammation in Nasal Polyps" @default.
• W2158582016 cites W1485297825 @default.
• W2158582016 cites W1514093028 @default.
• W2158582016 cites W1575476642 @default.
• W2158582016 cites W1581572449 @default.
• W2158582016 cites W1677380779 @default.
• W2158582016 cites W1965874282 @default.
• W2158582016 cites W1966013656 @default.
• W2158582016 cites W1977413050 @default.
• W2158582016 cites W1991307876 @default.
• W2158582016 cites W2021371448 @default.
• W2158582016 cites W2028960718 @default.
• W2158582016 cites W2036797577 @default.
• W2158582016 cites W2037289981 @default.
• W2158582016 cites W2041748354 @default.
• W2158582016 cites W2043992563 @default.
• W2158582016 cites W2048396983 @default.
• W2158582016 cites W2051594801 @default.
• W2158582016 cites W2055203083 @default.
• W2158582016 cites W2058816283 @default.
• W2158582016 cites W2066603202 @default.
• W2158582016 cites W2069526080 @default.
• W2158582016 cites W2071988945 @default.
• W2158582016 cites W2074372201 @default.
• W2158582016 cites W2077761171 @default.
• W2158582016 cites W2077762362 @default.
• W2158582016 cites W2083790049 @default.
• W2158582016 cites W2083838472 @default.
• W2158582016 cites W2096689446 @default.
• W2158582016 cites W2104332007 @default.
• W2158582016 cites W2129761445 @default.
• W2158582016 cites W2140707292 @default.
• W2158582016 cites W2144074168 @default.
• W2158582016 cites W2146341872 @default.
• W2158582016 cites W2150286434 @default.
• W2158582016 cites W2163789582 @default.
• W2158582016 cites W2164959292 @default.
• W2158582016 cites W2322375809 @default.
• W2158582016 doi "https://doi.org/10.1177/0194599815589582" @default.
• W2158582016 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/26084825" @default.
• W2158582016 hasPublicationYear "2015" @default.
• W2158582016 type Work @default.
• W2158582016 sameAs 2158582016 @default.
• W2158582016 citedByCount "3" @default.
• W2158582016 countsByYear W21585820162017 @default.
• W2158582016 countsByYear W21585820162018 @default.
• W2158582016 countsByYear W21585820162019 @default.
• W2158582016 crossrefType "journal-article" @default.
• W2158582016 hasAuthorship W2158582016A5015860750 @default.
• W2158582016 hasAuthorship W2158582016A5037605712 @default.
• W2158582016 hasAuthorship W2158582016A5038336908 @default.
• W2158582016 hasAuthorship W2158582016A5040154477 @default.
• W2158582016 hasConcept C104317684 @default.
• W2158582016 hasConcept C127561419 @default.
• W2158582016 hasConcept C142724271 @default.
• W2158582016 hasConcept C179264091 @default.
• W2158582016 hasConcept C185592680 @default.
• W2158582016 hasConcept C202751555 @default.
• W2158582016 hasConcept C203014093 @default.
• W2158582016 hasConcept C204232928 @default.
• W2158582016 hasConcept C2776042228 @default.
• W2158582016 hasConcept C2776415932 @default.
• W2158582016 hasConcept C2776914184 @default.
• W2158582016 hasConcept C2777037409 @default.
• W2158582016 hasConcept C2781390199 @default.
• W2158582016 hasConcept C55493867 @default.
• W2158582016 hasConcept C71924100 @default.
• W2158582016 hasConcept C88675164 @default.
• W2158582016 hasConceptScore W2158582016C104317684 @default.
• W2158582016 hasConceptScore W2158582016C127561419 @default.
• W2158582016 hasConceptScore W2158582016C142724271 @default.
• W2158582016 hasConceptScore W2158582016C179264091 @default.
• W2158582016 hasConceptScore W2158582016C185592680 @default.
• W2158582016 hasConceptScore W2158582016C202751555 @default.
• W2158582016 hasConceptScore W2158582016C203014093 @default.
• W2158582016 hasConceptScore W2158582016C204232928 @default.
• W2158582016 hasConceptScore W2158582016C2776042228 @default.
• W2158582016 hasConceptScore W2158582016C2776415932 @default.
• W2158582016 hasConceptScore W2158582016C2776914184 @default.
• W2158582016 hasConceptScore W2158582016C2777037409 @default.
• W2158582016 hasConceptScore W2158582016C2781390199 @default.
• W2158582016 hasConceptScore W2158582016C55493867 @default.
• W2158582016 hasConceptScore W2158582016C71924100 @default.
• W2158582016 hasConceptScore W2158582016C88675164 @default.
• W2158582016 hasFunder F4320321001 @default.
• W2158582016 hasIssue "3" @default.
• W2158582016 hasLocation W21585820161 @default.
• W2158582016 hasLocation W21585820162 @default.
• W2158582016 hasOpenAccess W2158582016 @default.
• W2158582016 hasPrimaryLocation W21585820161 @default.

• next