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• W2158587710 endingPage "1376" @default.
• W2158587710 startingPage "1361" @default.
• W2158587710 abstract "Most infectious diseases are caused by pathogenic infiltrations from the mucosal tract. Therefore, vaccines delivered to the mucosal tissues can mimic natural infections and provide protection at the first site of infection. Thus, mucosal, especially, oral delivery is becoming the most preferred mode of vaccination. However, oral vaccines have to overcome several barriers such as the extremely low pH of the stomach, the presence of proteolytic enzymes and bile salts as well as low permeability in the intestine. Several formulations based on nanoparticle strategies are currently being explored to prepare stable oral vaccine formulations. This review briefly discusses several molecular mechanisms involved in intestinal immune cell activation and various aspects of oral nanoparticle-based vaccine design that should be considered for improved mucosal and systemic immune responses." @default.
• W2158587710 created "2016-06-24" @default.
• W2158587710 creator A5008581557 @default.
• W2158587710 creator A5028490375 @default.
• W2158587710 creator A5089357963 @default.
• W2158587710 date "2014-08-26" @default.
• W2158587710 modified "2023-10-09" @default.
• W2158587710 title "Oral delivery of nanoparticle-based vaccines" @default.
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