Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158600898> ?p ?o ?g. }
- W2158600898 endingPage "12196" @default.
- W2158600898 startingPage "12187" @default.
- W2158600898 abstract "ABSTRACT Open reading frame 45 (ORF45) of Kaposi's sarcoma-associated herpesvirus (KSHV) encodes an immediate-early protein. This protein is also present in virions as a tegument protein. ORF45 protein interacts with interferon regulatory factor 7 (IRF-7) and inhibits virus-induced type I interferon production by blocking activation of IRF-7. To define further the function of ORF45 and the mechanism underlying its action, we constructed an ORF45-null recombinant virus genome (BAC-stop45) by using a bacterial artificial chromosome (BAC) system. Stable 293T cells carrying the BAC36 (wild type) and BAC-stop45 genomes were generated. When monolayers of 293T BAC36 and 293T BAC-stop45 cells were induced with 12- O -tetradecanoylphorbol-13-acetate and sodium butyrate, no significant difference was found between them in overall viral gene expression and lytic DNA replication, but induced 293T BAC-stop45 cells released 10-fold fewer virions to the medium than did 293T BAC36 cells. When ORF45-null virus was used to infect cells, lower infectivity was observed than for wild-type BAC36. These results suggest that KSHV ORF45 plays roles in both early and late stages of viral infection, probably in viral ingress and egress." @default.
- W2158600898 created "2016-06-24" @default.
- W2158600898 creator A5001665699 @default.
- W2158600898 creator A5010896860 @default.
- W2158600898 creator A5053978927 @default.
- W2158600898 creator A5068482144 @default.
- W2158600898 creator A5090590010 @default.
- W2158600898 date "2006-12-15" @default.
- W2158600898 modified "2023-10-10" @default.
- W2158600898 title "Functional Characterization of Kaposi's Sarcoma-Associated Herpesvirus ORF45 byBacterial Artificial Chromosome-Based Mutagenesis" @default.
- W2158600898 cites W1532938692 @default.
- W2158600898 cites W1587335760 @default.
- W2158600898 cites W1591020212 @default.
- W2158600898 cites W1905217533 @default.
- W2158600898 cites W1907539319 @default.
- W2158600898 cites W1962970685 @default.
- W2158600898 cites W1975012237 @default.
- W2158600898 cites W1981459273 @default.
- W2158600898 cites W1988736583 @default.
- W2158600898 cites W2008205503 @default.
- W2158600898 cites W2011678998 @default.
- W2158600898 cites W2025878116 @default.
- W2158600898 cites W2027587005 @default.
- W2158600898 cites W2032438721 @default.
- W2158600898 cites W2044627970 @default.
- W2158600898 cites W2051221600 @default.
- W2158600898 cites W2061789335 @default.
- W2158600898 cites W2080385928 @default.
- W2158600898 cites W2103246049 @default.
- W2158600898 cites W2107261529 @default.
- W2158600898 cites W2113627003 @default.
- W2158600898 cites W2117469001 @default.
- W2158600898 cites W2120055283 @default.
- W2158600898 cites W2120246830 @default.
- W2158600898 cites W2121114975 @default.
- W2158600898 cites W2123837005 @default.
- W2158600898 cites W2124157550 @default.
- W2158600898 cites W2131933513 @default.
- W2158600898 cites W2136990658 @default.
- W2158600898 cites W2138395245 @default.
- W2158600898 cites W2140436032 @default.
- W2158600898 cites W2142404794 @default.
- W2158600898 cites W2145561586 @default.
- W2158600898 cites W2147722098 @default.
- W2158600898 cites W2147890616 @default.
- W2158600898 cites W2158046192 @default.
- W2158600898 cites W2163863526 @default.
- W2158600898 cites W2165155404 @default.
- W2158600898 cites W2168492746 @default.
- W2158600898 cites W2340640662 @default.
- W2158600898 cites W4254613993 @default.
- W2158600898 doi "https://doi.org/10.1128/jvi.01275-06" @default.
- W2158600898 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1676278" @default.
- W2158600898 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17035322" @default.
- W2158600898 hasPublicationYear "2006" @default.
- W2158600898 type Work @default.
- W2158600898 sameAs 2158600898 @default.
- W2158600898 citedByCount "61" @default.
- W2158600898 countsByYear W21586008982012 @default.
- W2158600898 countsByYear W21586008982013 @default.
- W2158600898 countsByYear W21586008982014 @default.
- W2158600898 countsByYear W21586008982015 @default.
- W2158600898 countsByYear W21586008982016 @default.
- W2158600898 countsByYear W21586008982017 @default.
- W2158600898 countsByYear W21586008982018 @default.
- W2158600898 countsByYear W21586008982019 @default.
- W2158600898 countsByYear W21586008982020 @default.
- W2158600898 countsByYear W21586008982021 @default.
- W2158600898 countsByYear W21586008982022 @default.
- W2158600898 countsByYear W21586008982023 @default.
- W2158600898 crossrefType "journal-article" @default.
- W2158600898 hasAuthorship W2158600898A5001665699 @default.
- W2158600898 hasAuthorship W2158600898A5010896860 @default.
- W2158600898 hasAuthorship W2158600898A5053978927 @default.
- W2158600898 hasAuthorship W2158600898A5068482144 @default.
- W2158600898 hasAuthorship W2158600898A5090590010 @default.
- W2158600898 hasBestOaLocation W21586008981 @default.
- W2158600898 hasConcept C104317684 @default.
- W2158600898 hasConcept C140704245 @default.
- W2158600898 hasConcept C141231307 @default.
- W2158600898 hasConcept C143065580 @default.
- W2158600898 hasConcept C146998594 @default.
- W2158600898 hasConcept C153911025 @default.
- W2158600898 hasConcept C159047783 @default.
- W2158600898 hasConcept C16318435 @default.
- W2158600898 hasConcept C174510640 @default.
- W2158600898 hasConcept C182615771 @default.
- W2158600898 hasConcept C182901222 @default.
- W2158600898 hasConcept C2522874641 @default.
- W2158600898 hasConcept C2776409557 @default.
- W2158600898 hasConcept C2780727368 @default.
- W2158600898 hasConcept C2780797929 @default.
- W2158600898 hasConcept C2781196997 @default.
- W2158600898 hasConcept C54355233 @default.
- W2158600898 hasConcept C86803240 @default.
- W2158600898 hasConceptScore W2158600898C104317684 @default.
- W2158600898 hasConceptScore W2158600898C140704245 @default.
- W2158600898 hasConceptScore W2158600898C141231307 @default.