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- W2158603922 abstract "Abstract. It is conceivable that the effect of a tumor, e.g., leukemia, upon the host depends as much on the total production of tumor cells as on their proliferation rate. For this reason an analysis of the human production rate of normal and leukemic cells was based on the in vivo 3 H‐thymidine‐labeling‐index variations found by Bond et al., and on thoracic duct drainage in patients with chronic lymphatic leukemia. Only three subjects were studied, none of them quite healthy, and several assumptions had to be made. However, the methods of analysis described may be of use. It is calculated that proerythroblasts divide most often—every five hours—and most quickly. With increasing maturity the proliferation rate appears to decrease; polychromatic erythroblasts divide only once in eight hours, and every division takes half an hour. Of the former cells 51 times 10 9 , of the latter 2.0 times 10 11 , are formed daily. In healthy persons the production may be somewhat smaller and times longer. Assuming that some animal data on the distribution and life span of lymphocytes can be extrapolated to man, the very tentative figure that lymphocytes recirculate from blood to lymph nodes and hack to blood about twice is obtained. In normal persons some 4 times 10 9 lymphocytes enter the blood daily via the thoracic duct, whereas in leukemia some 4 times 10 10 enter. Even if the leukemic lymphocytes did not recirculate at all and this latter figure equalled the real lymphocyte production in leukemia, it would be smaller than the production of normal orthochromatic erythroblasts. Even in these advanced cases of leukemia, accordingly, the total production of tumor cells appears to be small when compared to the total production of normal bone marrow cells. Thoracic duct drainage, like extra‐corporeal radiation, removes some 10 10 lymphocytes daily, or about one daily production, and causes lymph nodes to decrease, but unfortunately does not seem to improve the clinical condition of the patients." @default.
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- W2158603922 date "1969-01-12" @default.
- W2158603922 modified "2023-10-16" @default.
- W2158603922 title "NORMAL AND LEUKEMIC CELL PRODUCTION IN MAN1" @default.
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- W2158603922 doi "https://doi.org/10.1111/j.0954-6820.1969.tb07294.x" @default.
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