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- W2158614242 abstract "Proper elastic fiber formation is required to maintain sufficient blood flow and smooth muscle cell function, but elastic fiber formation is impaired with age and by health conditions including aneurysms and atherosclerosis. Despite considerable progress in the understanding of elastogenesis and degradation of elastic fibers using the planar culture system and animals with genetic modifications, it remains difficult to restore elastic fibers in diseased vessels. To further study the molecular mechanisms and the development of therapeutic strategies, a new experimental tool for vascular biology is required. Using a hierarchical cell manipulation technique, we developed three-dimensional cellular multilayers (3DCMs) that exhibited layered elastic fiber formation within 7 days of being in a static culture condition. In this vascular model, the formation of elastic fibers was disturbed by BAPN, an inhibitor of elastin cross-linking. Furthermore, gene expression profiles of smooth muscle cell phenotypic markers suggested that smooth muscle cells show more contractile phenotypes in 3DCMs than in smooth muscle cells of 2D culture. In conclusion, the 3DCMs have the potential to serve as a new vascular experimental platform in which the spatial and temporal regulation of vascular remodeling can be studied." @default.
- W2158614242 created "2016-06-24" @default.
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- W2158614242 date "2014-01-01" @default.
- W2158614242 modified "2023-09-24" @default.
- W2158614242 title "Reconstruction of Elastic Fibers in Three-Dimensional Smooth Muscle Cells" @default.
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