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• W2158624923 abstract "The new research criteria for MCI due to AD proposed by the National Institute on Aging and Alzheimer's association (NIA-AA) differ from those by Dubois and co-workers (2007) in that they consider both amnestic MCI (aMCI) and non-amnestic MCI (naMCI) as prodromal stages of AD. AD may, however, present different in aMCI and naMCI and AD biomarkers may have a different predictive accuracy for AD in both MCI subtypes. Aim of this study was to compare the predictive accuracy of beta amyloid (Aβ)1-42 and tau in cerebrospinal fluid (CSF) for AD in subjects with aMCI and naMCI. We selected 156 subjects with aMCI and 75 with naMCI from the European DESCRIPA multi-center study and Alzheimer center of the VU University Medical Center. CSF Aβ1-42 and CSF total tau were measured by ELISA. Outcome measures were progression to AD and annual decline on the MMSE after a 5-year follow-up. 67 (46%) subjects with aMCI and 24 (35%) subjects with naMCI progressed to AD after 3.4 years of follow-up. Age and APOE genotype did not differ between MCI subgroups. CSF Aβ1-42 and CSF tau predicted AD equally well in each MCI subgroup (hazard ratios: P <0.01). Baseline CSF Aβ1-42 levels were significantly lower in subjects with aMCI with AD at follow-up (415pg/ml) compared to subjects with naMCI with AD at follow-up (526pg/ml). CSF tau levels were not different between subjects with aMCI and naMCI with AD at follow-up. Subjects with naMCI and normal CSF Aβ1-42 with AD at follow-up tended to show higher decline on the MMSE than those with abnormal CSF Aβ1-42 who progressed to AD (annual slope -1.91vs-0.92;table). AD biomarkers are useful to predict AD in subjects with aMCI and naMCI. CSF Aβ1-42 levels in subjects with naMCI, however, may not be as sensitive for early diagnosis compared to aMCI as concentrations were relatively high. Thiscould indicate that naMCI is an earlier stage of AD than aMCI. Alternatively, it is possible that in naMCI comorbidity is present such that less amyloid pathology might be needed to reach the dementia threshold. Our results may have implications for clinical implementation of the NIA-AA criteria." @default.
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• W2158624923 date "2012-07-01" @default.
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• W2158624923 title "O2-13-03: Cerebrospinal fluid markers for predicting Alzheimer's-type dementia in subjects with amnestic versus non-amnestic mild cognitive impairment" @default.
• W2158624923 doi "https://doi.org/10.1016/j.jalz.2012.05.698" @default.
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