FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158625518> ?p ?o ?g. }

• W2158625518 endingPage "624" @default.
• W2158625518 startingPage "604" @default.
• W2158625518 abstract "Spermatozoa are highly differentiated, transcriptionally inert cells characterized by a compact nucleus with minimal cytoplasm. Nevertheless they contain a suite of unique RNAs that are delivered to oocyte upon fertilization. They are likely integrated as part of many different processes including genome recognition, consolidation-confrontation, early embryonic development and epigenetic transgenerational inherence. Spermatozoal RNAs also provide a window into the developmental history of each sperm thereby providing biomarkers of fertility and pregnancy outcome which are being intensely studied. Literature searches were performed to review the majority of spermatozoal RNA studies that described potential functions and clinical applications with emphasis on Next-Generation Sequencing. Human, mouse, bovine and stallion were compared as their distribution and composition of spermatozoal RNAs, using these techniques, have been described. Comparisons highlighted the complexity of the population of spermatozoal RNAs that comprises rRNA, mRNA and both large and small non-coding RNAs. RNA-seq analysis has revealed that only a fraction of the larger RNAs retain their structure. While rRNAs are the most abundant and are highly fragmented, ensuring a translationally quiescent state, other RNAs including some mRNAs retain their functional potential, thereby increasing the opportunity for regulatory interactions. Abundant small non-coding RNAs retained in spermatozoa include miRNAs and piRNAs. Some, like miR-34c are essential to the early embryo development required for the first cellular division. Others like the piRNAs are likely part of the genomic dance of confrontation and consolidation. Other non-coding spermatozoal RNAs include transposable elements, annotated lnc-RNAs, intronic retained elements, exonic elements, chromatin-associated RNAs, small-nuclear ILF3/NF30 associated RNAs, quiescent RNAs, mse-tRNAs and YRNAs. Some non-coding RNAs are known to act as epigenetic modifiers, inducing histone modifications and DNA methylation, perhaps playing a role in transgenerational epigenetic inherence. Transcript profiling holds considerable potential for the discovery of fertility biomarkers for both agriculture and human medicine. Comparing the differential RNA profiles of infertile and fertile individuals as well as assessing species similarities, should resolve the regulatory pathways contributing to male factor infertility. Dad delivers a complex population of RNAs to the oocyte at fertilization that likely influences fertilization, embryo development, the phenotype of the offspring and possibly future generations. Development is continuing on the use of spermatozoal RNA profiles as phenotypic markers of male factor status for use as clinical diagnostics of the father's contribution to the birth of a healthy child." @default.
• W2158625518 created "2016-06-24" @default.
• W2158625518 creator A5009719215 @default.
• W2158625518 creator A5030329689 @default.
• W2158625518 creator A5038485124 @default.
• W2158625518 creator A5039579890 @default.
• W2158625518 creator A5045463023 @default.
• W2158625518 date "2013-07-14" @default.
• W2158625518 modified "2023-10-02" @default.
• W2158625518 title "The presence, role and clinical use of spermatozoal RNAs" @default.
• W2158625518 cites W106696345 @default.
• W2158625518 cites W11909344 @default.
• W2158625518 cites W1535530912 @default.
• W2158625518 cites W1666882487 @default.
• W2158625518 cites W1686333409 @default.
• W2158625518 cites W178618994 @default.
• W2158625518 cites W191736199 @default.
• W2158625518 cites W1964113455 @default.
• W2158625518 cites W1966990812 @default.
• W2158625518 cites W1968476384 @default.
• W2158625518 cites W1969117475 @default.
• W2158625518 cites W1969127101 @default.
• W2158625518 cites W1970423013 @default.
• W2158625518 cites W1971311795 @default.
• W2158625518 cites W1971708895 @default.
• W2158625518 cites W1972377244 @default.
• W2158625518 cites W1972492786 @default.
• W2158625518 cites W1977733607 @default.
• W2158625518 cites W1977905073 @default.
• W2158625518 cites W1979025775 @default.
• W2158625518 cites W1979347838 @default.
• W2158625518 cites W1979662111 @default.
• W2158625518 cites W1979729089 @default.
• W2158625518 cites W1982287231 @default.
• W2158625518 cites W1983643695 @default.
• W2158625518 cites W1983826553 @default.
• W2158625518 cites W1985098845 @default.
• W2158625518 cites W1986721429 @default.
• W2158625518 cites W1992188147 @default.
• W2158625518 cites W1993061318 @default.
• W2158625518 cites W1993419284 @default.
• W2158625518 cites W1993481243 @default.
• W2158625518 cites W1997666780 @default.
• W2158625518 cites W2000210567 @default.
• W2158625518 cites W2001395556 @default.
• W2158625518 cites W2005541422 @default.
• W2158625518 cites W2006077832 @default.
• W2158625518 cites W2006169630 @default.
• W2158625518 cites W2007702198 @default.
• W2158625518 cites W2008945738 @default.
• W2158625518 cites W2010504722 @default.
• W2158625518 cites W2011612823 @default.
• W2158625518 cites W2015120218 @default.
• W2158625518 cites W2015370938 @default.
• W2158625518 cites W2016018975 @default.
• W2158625518 cites W2016721108 @default.
• W2158625518 cites W2018199671 @default.
• W2158625518 cites W2018391507 @default.
• W2158625518 cites W2018783729 @default.
• W2158625518 cites W2019623019 @default.
• W2158625518 cites W2020331089 @default.
• W2158625518 cites W2020527412 @default.
• W2158625518 cites W2022245088 @default.
• W2158625518 cites W2023370737 @default.
• W2158625518 cites W2025279977 @default.
• W2158625518 cites W2026222098 @default.
• W2158625518 cites W2026449110 @default.
• W2158625518 cites W2026699038 @default.
• W2158625518 cites W2027205346 @default.
• W2158625518 cites W2027306897 @default.
• W2158625518 cites W2027319991 @default.
• W2158625518 cites W2028010103 @default.
• W2158625518 cites W2029339391 @default.
• W2158625518 cites W2030468760 @default.
• W2158625518 cites W2032878693 @default.
• W2158625518 cites W2033094967 @default.
• W2158625518 cites W2035074912 @default.
• W2158625518 cites W2035300822 @default.
• W2158625518 cites W2035853871 @default.
• W2158625518 cites W2036454804 @default.
• W2158625518 cites W2037108634 @default.
• W2158625518 cites W2037818631 @default.
• W2158625518 cites W2039196620 @default.
• W2158625518 cites W2039776069 @default.
• W2158625518 cites W2040356607 @default.
• W2158625518 cites W2040801294 @default.
• W2158625518 cites W2041482906 @default.
• W2158625518 cites W2044438508 @default.
• W2158625518 cites W2047927260 @default.
• W2158625518 cites W2047939916 @default.
• W2158625518 cites W2048175200 @default.
• W2158625518 cites W2048452977 @default.
• W2158625518 cites W2048460471 @default.
• W2158625518 cites W2049211478 @default.
• W2158625518 cites W2049353645 @default.
• W2158625518 cites W2050138691 @default.
• W2158625518 cites W2052228825 @default.
• W2158625518 cites W2053833990 @default.

• next