Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158625752> ?p ?o ?g. }
- W2158625752 endingPage "449" @default.
- W2158625752 startingPage "445" @default.
- W2158625752 abstract "Eighty-one patients treated with high-dose therapy and autologous stem cell transplantation (ASCT) as part of salvage therapy after a frontline ASCT were included in a retrospective analysis. The median time between the first and the salvage ASCT was 47 months. After salvage ASCT, 75 patients (93%) achieved at least a partial response, including 67% very good partial responses, and no toxic death was reported. Sixteen patients (20%) underwent consolidation therapy, whereas 30 patients (37%) underwent some form of maintenance therapy after salvage ASCT. For all patients, the median overall survival (OS) was 10 years from diagnosis and 4 years from salvage ASCT. The median progression-free survival (PFS) from the date of the first ASCT to the date of the first relapse was 40 months, and the median PFS from the date of salvage ASCT to the date of subsequent progression was 18 months. In the multivariate analysis of prognostic factors, three independent factors unfavorably affected PFS: a short duration of response to the first ASCT (cut-off value of 24 months), a response less than a very good partial response after salvage therapy, and no maintenance treatment after salvage ASCT. Age over 60 years and a short duration of response after the first ASCT were the two factors adversely affecting OS from the time of diagnosis and OS from the time of salvage ASCT. Our data show that salvage ASCT is a feasible option that should be routinely considered at the time of relapse for patients with a response duration of more than 2 years to frontline high-dose therapy." @default.
- W2158625752 created "2016-06-24" @default.
- W2158625752 creator A5003428531 @default.
- W2158625752 creator A5007623289 @default.
- W2158625752 creator A5011827756 @default.
- W2158625752 creator A5013649336 @default.
- W2158625752 creator A5030152912 @default.
- W2158625752 creator A5043743398 @default.
- W2158625752 creator A5062982333 @default.
- W2158625752 creator A5065205435 @default.
- W2158625752 creator A5069407733 @default.
- W2158625752 creator A5075950291 @default.
- W2158625752 creator A5079797607 @default.
- W2158625752 creator A5082685353 @default.
- W2158625752 creator A5082733021 @default.
- W2158625752 creator A5089853890 @default.
- W2158625752 date "2013-03-01" @default.
- W2158625752 modified "2023-10-18" @default.
- W2158625752 title "Autologous Stem Cell Transplantation: An Effective Salvage Therapy in Multiple Myeloma" @default.
- W2158625752 cites W1594485137 @default.
- W2158625752 cites W1973839697 @default.
- W2158625752 cites W1975771370 @default.
- W2158625752 cites W1991354959 @default.
- W2158625752 cites W1992538067 @default.
- W2158625752 cites W2018729528 @default.
- W2158625752 cites W2021954218 @default.
- W2158625752 cites W2037623634 @default.
- W2158625752 cites W2042085626 @default.
- W2158625752 cites W2044436186 @default.
- W2158625752 cites W2047840324 @default.
- W2158625752 cites W2071077687 @default.
- W2158625752 cites W2081716674 @default.
- W2158625752 cites W2102591890 @default.
- W2158625752 cites W2104200322 @default.
- W2158625752 cites W2111650326 @default.
- W2158625752 cites W2115760271 @default.
- W2158625752 cites W2125721471 @default.
- W2158625752 cites W2128084036 @default.
- W2158625752 cites W2128515279 @default.
- W2158625752 cites W2135349755 @default.
- W2158625752 cites W2142983307 @default.
- W2158625752 cites W2150878522 @default.
- W2158625752 cites W2168665970 @default.
- W2158625752 cites W2169774815 @default.
- W2158625752 cites W2557793171 @default.
- W2158625752 cites W2579749131 @default.
- W2158625752 cites W2585203934 @default.
- W2158625752 cites W3145716452 @default.
- W2158625752 cites W2139546963 @default.
- W2158625752 doi "https://doi.org/10.1016/j.bbmt.2012.11.013" @default.
- W2158625752 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23186983" @default.
- W2158625752 hasPublicationYear "2013" @default.
- W2158625752 type Work @default.
- W2158625752 sameAs 2158625752 @default.
- W2158625752 citedByCount "60" @default.
- W2158625752 countsByYear W21586257522013 @default.
- W2158625752 countsByYear W21586257522014 @default.
- W2158625752 countsByYear W21586257522015 @default.
- W2158625752 countsByYear W21586257522016 @default.
- W2158625752 countsByYear W21586257522017 @default.
- W2158625752 countsByYear W21586257522018 @default.
- W2158625752 countsByYear W21586257522019 @default.
- W2158625752 countsByYear W21586257522020 @default.
- W2158625752 countsByYear W21586257522021 @default.
- W2158625752 countsByYear W21586257522022 @default.
- W2158625752 countsByYear W21586257522023 @default.
- W2158625752 crossrefType "journal-article" @default.
- W2158625752 hasAuthorship W2158625752A5003428531 @default.
- W2158625752 hasAuthorship W2158625752A5007623289 @default.
- W2158625752 hasAuthorship W2158625752A5011827756 @default.
- W2158625752 hasAuthorship W2158625752A5013649336 @default.
- W2158625752 hasAuthorship W2158625752A5030152912 @default.
- W2158625752 hasAuthorship W2158625752A5043743398 @default.
- W2158625752 hasAuthorship W2158625752A5062982333 @default.
- W2158625752 hasAuthorship W2158625752A5065205435 @default.
- W2158625752 hasAuthorship W2158625752A5069407733 @default.
- W2158625752 hasAuthorship W2158625752A5075950291 @default.
- W2158625752 hasAuthorship W2158625752A5079797607 @default.
- W2158625752 hasAuthorship W2158625752A5082685353 @default.
- W2158625752 hasAuthorship W2158625752A5082733021 @default.
- W2158625752 hasAuthorship W2158625752A5089853890 @default.
- W2158625752 hasBestOaLocation W21586257521 @default.
- W2158625752 hasConcept C126322002 @default.
- W2158625752 hasConcept C141071460 @default.
- W2158625752 hasConcept C143998085 @default.
- W2158625752 hasConcept C2776364478 @default.
- W2158625752 hasConcept C2776694085 @default.
- W2158625752 hasConcept C2779050716 @default.
- W2158625752 hasConcept C2780775027 @default.
- W2158625752 hasConcept C38180746 @default.
- W2158625752 hasConcept C71924100 @default.
- W2158625752 hasConceptScore W2158625752C126322002 @default.
- W2158625752 hasConceptScore W2158625752C141071460 @default.
- W2158625752 hasConceptScore W2158625752C143998085 @default.
- W2158625752 hasConceptScore W2158625752C2776364478 @default.
- W2158625752 hasConceptScore W2158625752C2776694085 @default.
- W2158625752 hasConceptScore W2158625752C2779050716 @default.
- W2158625752 hasConceptScore W2158625752C2780775027 @default.