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• W2158634773 abstract "The synthesis of double-stranded DNA by a rolling circle mechanism was reconstituted in vitro with a replisome consisting of the DNA polymerase-UL42 complex and the heterotrimeric helicase-primase encoded by herpes simplex virus type 1. Okazaki fragments 3 kilobases in length and leading strands that may exceed 10 kilobases are produced. Lagging strand synthesis is stimulated by ribonucleoside triphosphates. DNA replication appears to be processive because it resists competition with an excess of (dT)(150)/(dA)(20). The single-strand DNA binding protein ICP8 is not required, and high concentrations of ICP8 can, in fact, inhibit lagging strand synthesis. The inhibition can, however, be overcome by the addition of an excess of the UL8 component of the helicase-primase. Rolling circle replication by the herpesvirus and bacteriophage T7 replisomes appears to proceed by a similar mechanism." @default.
• W2158634773 created "2016-06-24" @default.
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• W2158634773 date "2000-04-11" @default.
• W2158634773 modified "2023-09-26" @default.
• W2158634773 title "Leading and lagging strand DNA synthesis <i>in vitro</i> by a reconstituted herpes simplex virus type 1 replisome" @default.
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• W2158634773 doi "https://doi.org/10.1073/pnas.97.8.3896" @default.
• W2158634773 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/18113" @default.
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