Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158636958> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2158636958 endingPage "76" @default.
- W2158636958 startingPage "52" @default.
- W2158636958 abstract "In Hooded Lister rats IgE responses may be induced by administration of antigen together with one of a number of adjuvants. The primary IgE response may subsequently be enhanced either specifically by a further exposure to antigen (booster response) or non-specifically by infection with helminth parasites (potentiated response). In the latter case the enhanced response is associated with a great increase in total serum IgE. The primary response itself is not significantly influenced by variations in the general theme of conventional immunization, including dose or route of administration of antigen, or the nature of the adjuvant employed. The booster response however is inhibited, a) in rats primed with a 'large' (e.g. greater than 100 microgram EA) dose of antigen and B. pertussis, and b) rats primed with any dose of antigen given in Al(OH)3 or CFA, and c) following repeated booster doses of soluble (i.e. unadjuvanted antigen even at a dosage of a few picogrammes. It is thought that each of the stimuli generate antigen specific suppressor T cells. Live worm parasites selectively, but non-specifically, stimulate heterologous antigen primed IgE responses. The evidence suggests that it may be this non-specific IgE stimulating effect rather than the parasite specific IgE response per se which leads to the great elevation of total serum IgE. Other immunoglobulin classes are not elevated in the same way. The potentiated IgE response is not susceptible to the suppressive influence generated by previous administration of large or repeated doses of the heterologous antigen. On the other hand, a parasite specific regulatory mechanism acts to prevent repotentiation of the heterologous (but not the parasite specific or total IgE) responses following reinfection. These results are discussed in relation to the work of others in rats and other species." @default.
- W2158636958 created "2016-06-24" @default.
- W2158636958 creator A5016650630 @default.
- W2158636958 date "1978-10-01" @default.
- W2158636958 modified "2023-09-23" @default.
- W2158636958 title "Stimuli for the Production and Control of IgE in Rats" @default.
- W2158636958 cites W1483635441 @default.
- W2158636958 cites W1486036223 @default.
- W2158636958 cites W1524053774 @default.
- W2158636958 cites W1527091895 @default.
- W2158636958 cites W155471268 @default.
- W2158636958 cites W155584830 @default.
- W2158636958 cites W1605649689 @default.
- W2158636958 cites W1976662981 @default.
- W2158636958 cites W1977192726 @default.
- W2158636958 cites W1985037048 @default.
- W2158636958 cites W1988112755 @default.
- W2158636958 cites W1992111384 @default.
- W2158636958 cites W1994515803 @default.
- W2158636958 cites W2002757160 @default.
- W2158636958 cites W2006806217 @default.
- W2158636958 cites W2007343762 @default.
- W2158636958 cites W2008174408 @default.
- W2158636958 cites W2010799832 @default.
- W2158636958 cites W2017581239 @default.
- W2158636958 cites W2018531218 @default.
- W2158636958 cites W2038162224 @default.
- W2158636958 cites W2062861971 @default.
- W2158636958 cites W2076432349 @default.
- W2158636958 cites W2076683150 @default.
- W2158636958 cites W2076685584 @default.
- W2158636958 cites W2080346912 @default.
- W2158636958 cites W2083866753 @default.
- W2158636958 cites W2085584249 @default.
- W2158636958 cites W2087000344 @default.
- W2158636958 cites W2168233861 @default.
- W2158636958 cites W218338265 @default.
- W2158636958 cites W2221926917 @default.
- W2158636958 cites W2224015555 @default.
- W2158636958 cites W2412524660 @default.
- W2158636958 doi "https://doi.org/10.1111/j.1600-065x.1978.tb01460.x" @default.
- W2158636958 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/360512" @default.
- W2158636958 hasPublicationYear "1978" @default.
- W2158636958 type Work @default.
- W2158636958 sameAs 2158636958 @default.
- W2158636958 citedByCount "76" @default.
- W2158636958 countsByYear W21586369582016 @default.
- W2158636958 crossrefType "journal-article" @default.
- W2158636958 hasAuthorship W2158636958A5016650630 @default.
- W2158636958 hasConcept C104317684 @default.
- W2158636958 hasConcept C12590561 @default.
- W2158636958 hasConcept C141105273 @default.
- W2158636958 hasConcept C147483822 @default.
- W2158636958 hasConcept C159654299 @default.
- W2158636958 hasConcept C203014093 @default.
- W2158636958 hasConcept C2777863537 @default.
- W2158636958 hasConcept C2780115692 @default.
- W2158636958 hasConcept C2780801004 @default.
- W2158636958 hasConcept C55493867 @default.
- W2158636958 hasConcept C86803240 @default.
- W2158636958 hasConcept C8891405 @default.
- W2158636958 hasConceptScore W2158636958C104317684 @default.
- W2158636958 hasConceptScore W2158636958C12590561 @default.
- W2158636958 hasConceptScore W2158636958C141105273 @default.
- W2158636958 hasConceptScore W2158636958C147483822 @default.
- W2158636958 hasConceptScore W2158636958C159654299 @default.
- W2158636958 hasConceptScore W2158636958C203014093 @default.
- W2158636958 hasConceptScore W2158636958C2777863537 @default.
- W2158636958 hasConceptScore W2158636958C2780115692 @default.
- W2158636958 hasConceptScore W2158636958C2780801004 @default.
- W2158636958 hasConceptScore W2158636958C55493867 @default.
- W2158636958 hasConceptScore W2158636958C86803240 @default.
- W2158636958 hasConceptScore W2158636958C8891405 @default.
- W2158636958 hasIssue "1" @default.
- W2158636958 hasLocation W21586369581 @default.
- W2158636958 hasLocation W21586369582 @default.
- W2158636958 hasOpenAccess W2158636958 @default.
- W2158636958 hasPrimaryLocation W21586369581 @default.
- W2158636958 hasRelatedWork W1539989077 @default.
- W2158636958 hasRelatedWork W1674135449 @default.
- W2158636958 hasRelatedWork W2034807705 @default.
- W2158636958 hasRelatedWork W2220102944 @default.
- W2158636958 hasRelatedWork W2409441623 @default.
- W2158636958 hasRelatedWork W2419404186 @default.
- W2158636958 hasRelatedWork W2738326556 @default.
- W2158636958 hasRelatedWork W2903752946 @default.
- W2158636958 hasRelatedWork W3109192410 @default.
- W2158636958 hasRelatedWork W276659083 @default.
- W2158636958 hasVolume "41" @default.
- W2158636958 isParatext "false" @default.
- W2158636958 isRetracted "false" @default.
- W2158636958 magId "2158636958" @default.
- W2158636958 workType "article" @default.