FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2158652149> ?p ?o ?g. }

• W2158652149 endingPage "46" @default.
• W2158652149 startingPage "235" @default.
• W2158652149 abstract "To determine the efficacy of antiplatelet therapy as prophylaxis against deep venous thrombosis or pulmonary embolism in surgical and high risk medical patients.Overviews of all randomised trials of antiplatelet therapy that could have been available by March 1990 and in which deep venous thrombosis was assessed systematically.53 trials (total 8400 patients) of an average of two weeks of antiplatelet therapy versus control in general or orthopaedic surgery; nine trials (600 patients) of antiplatelet therapy versus control in other types of immobility; 18 trials (1000 patients) of one antiplatelet regimen versus another.Overall, a few weeks of antiplatelet therapy produced a highly significant (2P < 0.00001) reduction in deep venous thrombosis. 25% of patients allocated antiplatelet therapy versus 34% of appropriately adjusted controls had deep venous thrombosis detected by systematic fibrinogen scanning or venography, representing prevention in about 90 patients per 1000 allocated antiplatelet therapy. There was an even greater proportional reduction in pulmonary embolism: such emboli were detected among 47 (1.0%) antiplatelet allocated patients versus an adjusted control total of 129 (2.7%), representing prevention among about 17 patients per 1000 treated (2P < 0.00001). In analyses confined to surgical trials, the proportional reductions were similar and separately significant for nonfatal pulmonary embolism (0.7% antiplatelet therapy v 1.8% control; 2P < 0.00001) and for deaths attributed to pulmonary embolism (0.2% v 0.9%; 2P = 0.0001). There was a slight but non-significant excess of deaths from other causes (1.0% v 0.7%), which made the difference in total mortality nonsignificant, though still favourable (1.2% v 1.5%). Information on adding antiplatelet therapy to heparin was limited but, at least for pulmonary embolism, suggested more protection from the combination than from heparin alone. The proportional reduction in the odds of suffering a deep venous thrombosis was roughly the same in patients having general surgery, traumatic orthopaedic surgery, and elective orthopaedic surgery (and in medical patients who were at increased risk of thromboembolism). For pulmonary embolism the numbers affected were smaller, but again the reductions were highly significant both in general surgery (16 (0.5%) v 58 (1.7%) pulmonary emboli; 2P < 0.0001) and in orthopaedic surgery (28 (2.7%) v 63 (6.1%) pulmonary emboli; 2P < 0.0002).It had previously been supposed that antiplatelet therapy did not influence venous thromboembolism, and many surgeons and physicians do not use it routinely for thromboprophylaxis, even for patients who are at substantial risk of deep venous thrombosis or pulmonary embolism. These results indicate that antiplatelet therapy--either alone or, for greater effect, in addition to other proved forms of thromboprophylaxis (such as subcutaneous heparin)--should be considered." @default.
• W2158652149 created "2016-06-24" @default.
• W2158652149 creator A5001707815 @default.
• W2158652149 creator A5003385604 @default.
• W2158652149 creator A5024612214 @default.
• W2158652149 creator A5078990069 @default.
• W2158652149 date "1994-01-22" @default.
• W2158652149 modified "2023-10-06" @default.
• W2158652149 title "Collaborative overview of randomised trials of antiplatelet therapy--III: Reduction in venous thrombosis and pulmonary embolism by antiplatelet prophylaxis among surgical and medical patients. Antiplatelet Trialists' Collaboration." @default.
• W2158652149 cites W106153730 @default.
• W2158652149 cites W150901901 @default.
• W2158652149 cites W1892352796 @default.
• W2158652149 cites W1966578498 @default.
• W2158652149 cites W1973383876 @default.
• W2158652149 cites W1985982723 @default.
• W2158652149 cites W1995989817 @default.
• W2158652149 cites W1998785253 @default.
• W2158652149 cites W1999962702 @default.
• W2158652149 cites W2010599049 @default.
• W2158652149 cites W2012199487 @default.
• W2158652149 cites W2014270354 @default.
• W2158652149 cites W2020048522 @default.
• W2158652149 cites W2042885159 @default.
• W2158652149 cites W2047992519 @default.
• W2158652149 cites W2052088174 @default.
• W2158652149 cites W2061309400 @default.
• W2158652149 cites W2064985248 @default.
• W2158652149 cites W2069217807 @default.
• W2158652149 cites W2071068532 @default.
• W2158652149 cites W2072804344 @default.
• W2158652149 cites W2074065225 @default.
• W2158652149 cites W2081501210 @default.
• W2158652149 cites W2087919053 @default.
• W2158652149 cites W2089098721 @default.
• W2158652149 cites W2117077716 @default.
• W2158652149 cites W2126893307 @default.
• W2158652149 cites W2130580778 @default.
• W2158652149 cites W2150000105 @default.
• W2158652149 cites W2151880534 @default.
• W2158652149 cites W2169664000 @default.
• W2158652149 cites W2178066023 @default.
• W2158652149 cites W2276252837 @default.
• W2158652149 cites W2290572263 @default.
• W2158652149 cites W2296949340 @default.
• W2158652149 cites W2336435715 @default.
• W2158652149 cites W2398473171 @default.
• W2158652149 cites W2403269667 @default.
• W2158652149 cites W2404240108 @default.
• W2158652149 cites W2404424313 @default.
• W2158652149 cites W2404742152 @default.
• W2158652149 cites W2412008756 @default.
• W2158652149 cites W2416407924 @default.
• W2158652149 cites W2418065327 @default.
• W2158652149 cites W2442700706 @default.
• W2158652149 cites W2472317299 @default.
• W2158652149 cites W283371537 @default.
• W2158652149 cites W70359381 @default.
• W2158652149 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8054013" @default.
• W2158652149 hasPublicationYear "1994" @default.
• W2158652149 type Work @default.
• W2158652149 sameAs 2158652149 @default.
• W2158652149 citedByCount "210" @default.
• W2158652149 countsByYear W21586521492012 @default.
• W2158652149 countsByYear W21586521492013 @default.
• W2158652149 countsByYear W21586521492014 @default.
• W2158652149 countsByYear W21586521492015 @default.
• W2158652149 countsByYear W21586521492016 @default.
• W2158652149 countsByYear W21586521492017 @default.
• W2158652149 countsByYear W21586521492018 @default.
• W2158652149 countsByYear W21586521492019 @default.
• W2158652149 countsByYear W21586521492020 @default.
• W2158652149 countsByYear W21586521492021 @default.
• W2158652149 countsByYear W21586521492022 @default.
• W2158652149 countsByYear W21586521492023 @default.
• W2158652149 crossrefType "journal-article" @default.
• W2158652149 hasAuthorship W2158652149A5001707815 @default.
• W2158652149 hasAuthorship W2158652149A5003385604 @default.
• W2158652149 hasAuthorship W2158652149A5024612214 @default.
• W2158652149 hasAuthorship W2158652149A5078990069 @default.
• W2158652149 hasConcept C126322002 @default.
• W2158652149 hasConcept C141071460 @default.
• W2158652149 hasConcept C168563851 @default.
• W2158652149 hasConcept C2776265017 @default.
• W2158652149 hasConcept C2777265216 @default.
• W2158652149 hasConcept C2777628954 @default.
• W2158652149 hasConcept C2777849778 @default.
• W2158652149 hasConcept C2778269268 @default.
• W2158652149 hasConcept C2780011451 @default.
• W2158652149 hasConcept C2780868729 @default.
• W2158652149 hasConcept C2781413609 @default.
• W2158652149 hasConcept C71924100 @default.
• W2158652149 hasConceptScore W2158652149C126322002 @default.
• W2158652149 hasConceptScore W2158652149C141071460 @default.
• W2158652149 hasConceptScore W2158652149C168563851 @default.
• W2158652149 hasConceptScore W2158652149C2776265017 @default.
• W2158652149 hasConceptScore W2158652149C2777265216 @default.
• W2158652149 hasConceptScore W2158652149C2777628954 @default.
• W2158652149 hasConceptScore W2158652149C2777849778 @default.

• next