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• W2158673119 endingPage "886" @default.
• W2158673119 startingPage "877" @default.
• W2158673119 abstract "Little is known regarding the role of γδ+ T cells in organ transplantation. We previously reported that immunologic unresponsiveness is induced by prior donor-specific blood transfusion (DST) in rat hepatic allografts. We investigated the phenotype and distribution of γδ+ T cells in the hepatic allograft, spleen, and peripheral blood of recipient rats with immunologic unresponsiveness induced by DST. γδ+ T cells were enumerated in allograft livers and spleens by immunostaining and in blood by flow cytometric analysis. The phenotype of γδ+ T cells was determined using CD45RC isoforms derived from alternative mRNA splicing. The cytokine profile of CD45RC+ and CD45RC− γδ+ T cells was analyzed by reverse transcription polymerase chain reaction. The number of γδ+ T cells in hepatic infiltrates in recipient rats pretreated with DST was significantly greater than in untreated animals. This correlated with significantly higher levels of γδ T cell receptor (TCR) mRNA in hepatic allografts of DST–treated rats as compared with untreated animals. The γδ+ T cell/αβ+ T-cell ratio increased in hepatic infiltrates in DST–treated recipient rats but not in untreated animals. CD45RC−γδ+ T cells were predominantly increased in DST–treated hepatic allografts compared with untreated allografts. Most of the intestinal intraepithelial T cells were CD45RC−γδ+. Interleukin (IL)-10 and IL-4 mRNA were detected more in CD45RC−γδ+ T cells than CD45RC+γδ+ T cells. CD45RC−γδ+ T cells infiltrating liver allografts produce Th2-type cytokines and are associated with immunologic unresponsiveness induced by DST." @default.
• W2158673119 created "2016-06-24" @default.
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• W2158673119 date "2001-04-01" @default.
• W2158673119 modified "2023-09-26" @default.
• W2158673119 title "CD45RC− γδ+ T-cell infiltration is associated with immunologic unresponsiveness induced by prior donor-specific blood transfusion in rat hepatic allografts" @default.
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• W2158673119 doi "https://doi.org/10.1053/jhep.2001.23503" @default.
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• W2158673119 hasPublicationYear "2001" @default.
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