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- W2158681708 abstract "In drug discovery, there is a clear and urgent need for detection of cell-membrane ion-channel operation with wide-field capability. Existing techniques are generally invasive or require specialized nanostructures. We show that quantum nanotechnology could provide a solution. The nitrogen-vacancy (NV) center in nanodiamond is of great interest as a single-atom quantum probe for nanoscale processes. However, until now nothing was known about the quantum behavior of a NV probe in a complex biological environment. We explore the quantum dynamics of a NV probe in proximity to the ion channel, lipid bilayer, and surrounding aqueous environment. Our theoretical results indicate that real-time detection of ion-channel operation at millisecond resolution is possible by directly monitoring the quantum decoherence of the NV probe. With the potential to scan and scale up to an array-based system, this conclusion may have wide-ranging implications for nanoscale biology and drug discovery." @default.
- W2158681708 created "2016-06-24" @default.
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- W2158681708 date "2010-10-11" @default.
- W2158681708 modified "2023-09-29" @default.
- W2158681708 title "Monitoring ion-channel function in real time through quantum decoherence" @default.
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- W2158681708 doi "https://doi.org/10.1073/pnas.1002562107" @default.
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